Antiulcerogenic and Toxicological Studies of Glycyrrhiza glabra Roots Available in Local Market of Karachi (original) (raw)
Related papers
2015
Glycyrrhiza glabra L. is used in folk medicine for treatment of stomach disorders including peptic ulcers. The hydroalcoholic extract of Glycyrrhiza glabra L. (HEGG) was evaluated for antiulcerogenic activity and acute toxicity profile in mice. Various doses of HEGG (50-200 mg/kg) were administered orally to animals of different groups. Omeprazole and cimetidine at doses of 30 and 100 mg/kg were used as positive controls, respectively. Stomach was opened along the greater curvature then ulceration index was determined examining the inner lining of stomach. Oral administration of the extract at 1600 mg/kg did not produce toxic symptoms and mortality in mice. 2950 mg/kg was determined as the oral LD 50 . The HEGG (50-200 mg/kg) showed a significant reduction in ulcer index in HCl/Ethanol-induced ulcer. G. glabra extract (50-150 mg/kg) showed antiulcer activity against indomethacin-induced gastric lesions dose dependently. The extract effectively inhibited formation of gastric lesions ...
Histopathological evaluation of Glycyrrhiza glabra on aspirin induced gastric ulcer in mice
Pakistan Journal of Agricultural Sciences, 2015
Non-steroidal anti-inflammatory drugs (NSAIDs) have been frequently used for their anti-inflammatory, antipyretic and analgesic effects. Despite of such actions, these drugs also cause gastrotintestinal injury and produce gastric ulcers. In current study, antiulcer activity of Glycyrrhiza glabra was evaluated in adult male albino mice. Gastric ulcer was induced by administrating the high dose of aspirin to male adult albino mice. Treatment protocol was made for seven days. Group 1 was fed on normal diet, group 2 was given aspirin and group 3 was provided with standard treatment for ulcer, omeprazole along with aspirin. While groups 4, 5 and 6 were administered G. glabra roots powder at 250, 500 and 750 mg/kg body weight respectively, together with aspirin. Histopathological analysis was carried out to determine the gastroprotective activity of G. glabra. The results suggest that G. glabra has potent gastroprotective effect at highest dose.
Nutritional and therapeutic potential of Glycyrrhiza glabra L. roots
2019
This study was aimed to estimate the antioxidant, anti-diabetic, anti-amnesic, anti-biofilm, thrombolytic, hemolytic, and cytotoxic effects of G. glabra root extracts for nutritive and medicinal purpose. Antioxidant, alpha amylase, antiglycation, anti-amnesic, cytotoxic, thrombolytic and antibiofilm assays were performed. In the current research, G. glabra root extracts showed significant antioxidant (80.96 mg GAE/100 g TPC, 38.96 mg CE/100 g TFC, 46% DPPH scavenging), antidiabetic (75% antiglycation, 38.7% α-amylase inhibition), anti-amnesic (5.5%), hemolytic (19.46%), thrombolytic (35.4%) and antibiofilm (72% P. multocida, 51.57% S. aureus inhibition) activities. G. glabra root extracts have remarkable activity to fight against oxidative stress, hyperglycemia, blood coagulation, bacterial growth, DNA damage and memory enhancing ability that ensure its uses in food and pharmaceutical industries.
Glycyrrhiza glabra (Yashtimadhu) has extensive pharmacological effects for human beings. It is used for treating upper respiratory ailments including Coughs, hoarseness, sore throat and bronchitis. The Liquorice (Glycyrrhiza glabra) extracts have been used to treat chronic hepatitis, and also have used for therapeutic benefits against viruses, including Human immunodeficiency virus (HIV), Cytomegalovirus (CMV), and Herpes simplex virus (HSV). Deglycyrrhizinated liquorice (DGL) preparations were useful in treating various types of ulcers, while topical liquorice preparations have been used to sooth and heal skin eruptions, such as Psoriasis and herpetic lesions. It has also been found to be an Anti-stress and anabolic agent and to possess good anti-bacterial, anti-fungal, anti-oxidant, anti-tussive, hepatoprotective, and anti-inflammatory activities. The present review also lists its use in Hyperpigmentation, immune cell activation; wound healing, treatment of atopic dermatitis, Familial Mediterranean Fever, induction of apoptosis, reduction of serum testosterone, etc. Yashtimadhu also acts as Anti-cancer agent, shows protective effect in radiation injury and is useful in management of functional dyspepsia. This review summarizes the therapeutic potential of the Glycyrrhiza glabra in the treatment of various disorders.
Glycyrrhiza glabra (Yashtimadhu) has extensive pharmacological effects for human beings. It is used for treating upper respiratory ailments including Coughs, hoarseness, sore throat and bronchitis. The Liquorice (Glycyrrhiza glabra) extracts have been used to treat chronic hepatitis, and also have used for therapeutic benefits against viruses, including Human immunodeficiency virus (HIV), Cytomegalovirus (CMV), and Herpes simplex virus (HSV). Deglycyrrhizinated liquorice (DGL) preparations were useful in treating various types of ulcers, while topical liquorice preparations have been used to sooth and heal skin eruptions, such as Psoriasis and herpetic lesions. It has also been found to be an Anti-stress and anabolic agent and to possess good anti-bacterial, anti-fungal, anti-oxidant, anti-tussive, hepatoprotective, and anti-inflammatory activities. The present review also lists its use in Hyperpigmentation, immune cell activation; wound healing, treatment of atopic dermatitis, Familial Mediterranean Fever, induction of apoptosis, reduction of serum testosterone, etc. Yashtimadhu also acts as Anti-cancer agent, shows protective effect in radiation injury and is useful in management of functional dyspepsia. This review summarizes the therapeutic potential of the Glycyrrhiza glabra in the treatment of various disorders.
A brief review on ethnobotanical, pharmaceutical and therapeutical uses of Glycyrrhiza glabra
The Pharma Innovation Journal, 2021
Glycyrrhiza glabra is a perennial herb, belonging to family fabaceae. It is also known as Licorice, sweet wood, Liquorice. It is a popular ingredient and well known remedy for coughs, syrups and various medicines with its relieving properties. Glycyrrhiza glabra Linn. Is one of the most important herb which is used in Ayurvedic medication since thousands of years. Medicinal plants are often used for treating various diseases. Now a days, the demand various herbal medicines, pharmaceuticals & health related products is increasing widely. Herbal medicine, include fruit, vegetables, as dry material on the extract of Glycyrrhiza to cure different diseases and maintenance of health. Glycyrrhiza is used in herbal preparation which is obtained from licorice roots for the treatment of liver related diseases. The root can help to heal gastric ulceration. It is also used in traditional medicine for its ethnobotanical and pharmacological value. It possesses anti-oxidant, antibacterial, antifun...
Pharmacological studies of Glycyrrhiza glabra- a review
Pharmacologyonline
Glycyrrhiza glabra, also known as liquorice and sweetwood, is native to the Mediterranean and certain areas of Asia. Historically, the dried rhizome and root of this plant were used medicinally by the Egyptian, Chinese, Greek, Indian and Roman civilizations as carminative, expectorant and cough remedies. It is now known that glycyrrhizic acid and its aglycone glycyrrhetinic acid present in the root extract are responsible for the biological activities. In modern medicine, liquorice extracts are employed as parenteral preparation for Chronic Hepatitis, Ulcer, viral infection and some common diseases. In Japan, it is used as pharmaceutical preparation since, 1960 years. In the present context glycyrrhizin and its derivative is focus on pharmacological studies, against disease viz. HIV syndrome, Hepatitis, H1N1 flue, cancer and diabetes etc.
Phytochemistry and Pharmacological Studies of Glycyrrhiza glabra: A Medicinal Plant Review
International Journal of Pharmaceutical Sciences Review and Research
Plants have been one of the important sources of medicines for human being and animals since the ancient time. Herbal medicines have attained popularity at global level to replace the synthetic chemicals as they have shown less adverse reactions. Glycyrrhiza glabra Linn is a herb belonging to the family Leguminosae, also known as Liquorice and sweetwood, is native to the Mediterranean and certain areas of Asia. Historically, the dried rhizome and root of this plant were employed medicinally by the Egyptian, Chinese, Greek, Indian and Roman civilizations as an expectorant and carminative. It is widely used in ayurvedic formulations and herb for different diseases. Present review article deals with chemical constituents present in various parts of Glycyrrhiza glabra and pharmacological activities. Present article object to comply all the updated information on its phytochemical and pharmacological activities which were performed by widely different methods. Glycyrrhiza glabra Linn possesses antibacterial, antioxidant, antimalarial, antispasmodic, anti-inflammatory and anti-hyper glycemic properties. Various other effects like antiulcer, antiviral, antifungal have also been discussed. A large number of components have been isolated from liquorice including triterpene saponins, flavonoids, isoflavonoids and chalcones, glycyrrhizic acid normally being considered to be the main biologically active component. This will be helpful to create interest towards liquorice and may be useful in developing new formulations with more therapeutic and economical value.