Diazinones as P2 replacements for pyrazole-based cathepsin S inhibitors (original) (raw)

Discovery of selective and nonpeptidic cathepsin S inhibitors

Kazuhiko Nonomura

Bioorganic & Medicinal Chemistry Letters, 2008

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6-Phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile as cathepsin S inhibitors

Tommi Meulemans, Iain Martin, Leon van Berkom, Sylviane Boucharens, Jiaqiang Cai

Bioorganic & Medicinal Chemistry Letters, 2010

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Pyrazole-based cathepsin S inhibitors with improved cellular potency

Siquan Sun, Steven Meduna

Bioorganic & Medicinal Chemistry Letters, 2007

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Pyrazole-based cathepsin S inhibitors with arylalkynes as P1 binding elements

Siquan Sun, Scott Bembenek

Bioorganic & Medicinal Chemistry Letters, 2009

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Discovery and SAR of novel pyrazole-based thioethers as cathepsin S inhibitors. Part 2: Modification of P3, P4, and P5 regions

Bioorganic & Medicinal Chemistry Letters, 2010

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Design, synthesis, and evaluation of inhibitors of cathepsin L: Exploiting a unique thiocarbazate chemotype

Bioorganic & Medicinal Chemistry Letters, 2008

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The design of potent hydrazones and disulfides as cathepsin S inhibitors

Maurice Morelock

Bioorganic & Medicinal Chemistry, 2003

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Discovery and SAR studies of a novel series of noncovalent cathepsin S inhibitors

Bioorganic & Medicinal Chemistry Letters, 2005

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New Cathepsin Inhibitors to Explore the Fluorophilic Properties of the S2 Pocket of Cathepsin B: Design, Synthesis, and Biological Evaluation

F Javier Cañada

Chemistry - A European Journal, 2011

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Discovery of Novel Cathepsin S Inhibitors by Pharmacophore-Based Virtual High-Throughput Screening

Christian Laggner, Gudrun Spitzer, Daniela Schuster

Journal of Chemical Information and Modeling, 2008

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Discovery of Novel Tetrahydropyrido-Pyrazole based Cathepsin S Inhibitors: Implications of Two Dimensional Quantitative Structure Activity Relationship Analysis

Indian Journal of Pharmaceutical Sciences, 2022

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Thioether acetamides as P3 binding elements for tetrahydropyrido-pyrazole cathepsin S inhibitors

Bioorganic & Medicinal Chemistry Letters, 2010

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Structural basis for reversible and irreversible inhibition of human cathepsin L by their respective dipeptidyl glyoxal and diazomethylketone inhibitors

Journal of Structural Biology, 2011

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In Search of Selective Inhibitors of Cysteine Protease, Cathepsin K

International Journal of Peptide Research and Therapeutics, 2005

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Substrate-derived triazolo- and azapeptides as inhibitors of cathepsins K and S

Fabien Lecaille

European journal of medicinal chemistry, 2018

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N-formylpyrazolines and N-benzoylpyrazolines as potential inhibitors cathepsin L

AIMS molecular science, 2016

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Identification of new peptide amides as selective cathepsin L inhibitors: The first step towards selective irreversible inhibitors?

Bioorganic & Medicinal Chemistry Letters, 2013

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