The Effect of Vitamin C on the Metabolic Parameters of Experimental Diabetes Mellitus (original) (raw)
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Asian Journal of Pharmaceutical and Clinical Research, 2020
Objectives: Diabetes mellitus (DM) is a spectrum of common metabolic disorders, arising from a variety of pathogenic mechanisms resulting in hyperglycemia that causes chronic micro-and macro-vascular complications. Vitamin C is structurally similar to glucose and can replace it in many chemical reactions and thus is effective in the prevention of non-enzymatic glycosylation of proteins. Hence, the present study taken up to see the effect of supplementation of Vitamin C on blood glucose and glycosylated hemoglobin (HbA1c) along with metformin in experimentally-induced diabetic rabbits. Methods: Twenty-four adult New Zealand white rabbits (1.5-2.5 kg) were divided into four groups, each containing six rabbits. Group 1: Normal control (distilled water); Group 2: Metformin (23.33 mg/kg) is given orally; Group 3: Metformin (23.33 mg/kg) plus Vitamin C 250 mg are given orally; and Group 4: Metformin (23.33 mg/kg) plus Vitamin C 500 mg are given orally. Animals were treated for 30 days. The blood samples were collected on days 0 and 30 from the marginal ear vein of rabbits for the estimation of blood glucose and HbA1c levels. Results: Statistically analyzed by ANOVA test followed by post hoc Tukey's test using GraphPad Prism software. Results shown that Vitamin C 500 mg oral supplementation with metformin had very highly significantly reduced HbA1c levels by 40.12% (p = 0.0001***) and blood glucose levels by 49.12% (p = 0.0003***), whereas Vitamin C 250 mg oral supplementation with metformin also significantly reduced HbA1c levels by 25.49% (p = 0.0001***) and blood glucose levels by 42.95% (p = 0.0026**) when compared to metformin alone, which reduced HbA1c levels by 22% (p = 0.0001***) and blood glucose levels by 39.58% (p = 0.0001***). Conclusion: Oral supplementation of Vitamin C 500 mg/250 mg to the metformin was superior in reducing HbA1c levels and blood glucose levels compared to metformin alone in rabbits. Hence, Vitamin C oral supplementation may be helpful in lowering blood glucose levels and HbA1c levels and improving glycemic control in Type 2 DM.
Iranian journal of diabetes and obesity (IJDO), 2023
Objective: Diabetes mellitus (DM) is a leading cause of morbidity and death worldwide. DM will affect 570.9 million people worldwide by 2025. The usefulness of vitamin C in improving diabetes control has been a point of contention. Materials and Methods: This clinical-trial double-blind study with control groups was conducted on 164 patients with type 2 diabetes mellitus (T2DM). The intervention group received 1000 mg of oral vitamin C daily, and a placebo was administered to the controls. To analyze the obtained data, one-way ANOVA was used in SPSS software (version 20). A P< 0.05 was considered statistically significant. Results: Fasting blood sugar (FBS), hemoglobin A1c (HbA1C), triglyceride (TG), and high-density lipoprotein (HDL) were improved significantly in the intervention group (P< 0.05), while the low-density lipoprotein (LDL) and cholesterol were unaffected (P> 0.05). HbA1C and LDL levels in the control group increased significantly (P< 0.05). Meanwhile, this group's HDL levels decreased considerably. Conclusion: Our findings support the consumption of vitamin C to complement the primary treatment for DM. According to our results, vitamin C provides a clear benefit over a placebo in the treatment of diabetic patients' serum parameters.
Acibadem Universitesi Saglik Bilimleri Dergisi
Eksojen antioksidan takviyesinin, diyabetin mikro ve makrovasküler komplikasyonlarına karşı faydalı olabileceği bilinmektedir. Bu çalışmada C vitamini desteğinin, diyabetik ratlarda, kronik hiperglisemiye bağlı olarak bozulan insülin sekresyonu, hiperlipidemi, oksidatif stres ve paraoksonaz-1 enzim (PON1) aktivitesi üzerine etkilerinin araştırılması amaçlanmıştır. Bu amaçla, yirmi dört adet Wistar albino cinsi rat C, DC ve DCC grupları olarak 3 gruba ayrıldı. DC ve DCC grubundaki ratlarda, tek doz streptozotosin enjeksiyonu ile diyabet oluşturuldu (45 mg/kg). C ve DC grubundaki ratlar standart rat yemi (C vitamini içermeyen) ile beslenirken, DCC grubundaki ratlar 200 mg/kg dozunda C vitamini ile desteklenmiş deneysel yemle beslendi. Elde edilen bulgulara göre, C grubundaki ratların sekiz haftalık deney süresinin sonunda diyabetik ratlara göre daha az yem ve su tükettiği görüldü (p
Vitamin C decreases the obesogenic and hyperglycemic effect of invert sugar in prediabetic rats
Revista de Nutrição
Objective: To evaluate whether vitamin C can help to prevent obesity and hyperglycemia in Wistar rats treated with excess invert sugar to induce prediabetes. Methods: One hundred-day-old Male Wistar rats with a mean weight of 336.58±23.43g were randomly assigned to the following groups: (1) control, receiving water (C); (2) invert sugar control, receiving a 32% watery solution of invert sugar; (3) vitamin C control, receiving a watery solution of vitamin C (60mg/L), and (4) vitamin C plus invert sugar, receiving a watery solution of vitamin C and invert sugar. All animals had access to chow and water ad libitum and were treated for 17 weeks. Prediabetes was assessed according to two criteria: obesity (based on body mass indexand peritoneal fat content) and impaired glucose tolerance (assessed by the intraperitoneal glucose tolerance test and expressed as area under the curve) . Results: Group invert sugar control gained significantly more weight (p=0.035) and visceral fat (p<0.00...
Effect of Vitamin C and/or Vitamin E on Oxidative Stress and Lipid Profile in Diabetic Rats
2020
Diabetes Mellitus is one of the main threats to human health in the 21 st century. The present study was planned to evaluate the effect of vitamin C and/or vitamin E as hypocholesterolemic, antioxidant agent on oxidative stress and serum lipid profile in streptozoticin induced-diabetic rats using glibenclamide as reference drug for treatment of type II diabetes. 120 male adult Sprague Dawley rats were divided into 6 groups, normal control (C), diabetic control (D), diabetic treated with: glibenclamide (D G ), vitamin C (D C ), vitamin E (D E ); vitamin C and E (D C+E ). Diabetic group (D) revealed a significant increase in glucose, HbA 1C (258.1 vs 88.9 gm/dl; 8.09 vs 5.55 gm/dl respectively), liver and plasma MDA (124.03, 134.24 vs 60.44,
Research in Experimental Medicine Zeitschrift Fur Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie, 2001
We determined the effects of intraperitoneally administered vitamin C on the lipid peroxidation (as thiobarbituric acid-reactive substances, TBARS) and vitamin C and E levels and reduced glutathione (GSH) and glutathione peroxidase (GSH-Px) activity in the plasma, red blood cells (RBC), liver, and muscle of rats in relation to oxidative damage associated with diabetes induced by streptozotocin (STZ). One group was used as control and a second as diabetic. A third group received 30 mg vitamin C i.p. every other day. On day 4 after the injection of vitamin C, animals in the second and third groups were made diabetic by i.p. injection of STZ and administered vitamin C for 21 consecutive days, and we determined TBARS, vitamin E, and GSH levels and GSH-Px activities in plasma, RBC, liver, and muscle samples. Vitamin E levels in the plasma and liver were significantly higher (P<0.05) in the control group than in the diabetic group. Also, TBARS levels in the plasma, RBC, liver, and muscle samples were significantly lower (P<0.05) in controls than in the diabetic group. The TBARS levels in the RBC, liver, and muscle samples of the vitamin C group were significantly lower (P<0.05, P<0.01, and P<0.001, respectively). However, GSH-Px and GSH activities in RBC, liver, and muscle and vitamin C levels in liver were not significantly different between control and diabetic groups. Vitamin E levels in plasma (P<0.05, P<0.01) and liver (P<0.001), vitamin C levels in liver (P<0.001), and GSH (P<0.01) and GSH-Px activities in RBC (P<0.05, P<0.01) were significantly higher in the vitamin C group than both the control and diabetic groups. These results indicate that vitamin C has significant protective effects on the blood, liver, and muscle of rats against oxidative damage in diabetes.
Role of Vitamin-C Supplementation in Type II Diabetes Mellitus
International journal of current research and review, 2020
Nutrients act as an important source in disease prevention and health care. Nutrients with vitamins are very important for cardiovascular health (i.e. vitamin B1), nerve function (i.e. vitamin B6 and vitamin B12), development of red blood cells (vitamin B12 and folate), coagulation (vitamin K) among other functions5. Decreased metabolic rates have been shown to correlate with an elevated body mass index (BMI) and increased obesity prevalence6
Family Medicine & Primary Care Review
Background. Diabetes mellitus (DM) is a metabolic disorder caused by many factors and related to serious complications. Diabetes mellitus includes oxidative stress and inflammation, in addition to hyperglycemia and resistance to insulin. Objectives. This study aimed to evaluate the effect of supplementation with vitamin C on blood glucose control and body mass index in type 2 diabetic patients of the family medicine outpatient clinic in Suez Canal University, Ismailia, Egypt. Material and methods. This was a double-blind, randomized, controlled clinical trial. Sixty patients (n = 60) were distributed randomly into two groups: the intervention group (on 1 g of vitamin C orally for 12 weeks), and the control group (on a placebo for the same period). Only 55 patients completed the study (28 in the intervention group and 27 in the control group). Glycated hemoglobin (HbA 1C %) and body mass index (BMI) were assessed at the beginning and after 12 weeks. Results. the Hba 1C percentage significantly decreased in the intervention group, supplemented with vitamin C, after 12 weeks as compared to the placebo group. The body mass index did not change significantly after the intervention. The intervention group had 75% glycemic improvement, while only 33.3% of the subjects improved in the control group. Absolute risk reduction (ARR) was 42%, the number of patients in need of treatment (NNT) was 2.38, the relative risk (RR) was 0.37, and the relative risk reduction (RRR) was 62%. Conclusions. Patients with type 2 diabetes may benefit from adding vitamin C to their routine management to control blood glucose.
International Journal of Innovation and Applied Studies, 2017
Diabetes mellitus is a group of metabolic disorders characterized by hyperglycemia. Intakes of vitamin C, Magnesium, Chromium, fiber and physical activity can help normalizing blood glucose level so as to prevent hyperglycemia. The aim of this study is to find out particular relations between vitamin C, Magnesium, Chromium, fiber, as well as physical activity and blood glucose levels in patients with diabetes mellitus at Dr. M. Yunus Hospital Bengkulu. This study was cross sectional approach. Sample population is Diabetes Mellitus Type II. Sampling is performed using purposive sampling with 50 samples. Intake data were obtained through 2 x 24 hours food recall form and PAL form. Data were analyzed using correlation regression and multiple linear regression. There were significant correlations between intakes of vitamin C (p = 0.001), Magnesium (p = 0.027), fiber (p = 0.028), physical activity (p = 0.001) and random blood glucose levels in patients with Diabetes Mellitus Type II. Con...
Journal of Bahria University Medical and Dental College, 2021
Objectives: To evaluate the effects of adjuvant vitamin C therapy with oral hypoglycemic on FBS, RBS and HbA1c and to find out the correlation of Vitamin C with glycemic indices. Study Design & Settings: This randomized open label clinical trial was conducted at Bahria University Medical & Dental College (BUMDC) in collaboration with NMC, Karachi from October 2018 to April 2019. Methodology: A total of 160 known type -2 males and females, uncomplicated diabetics, aged 40-65 years with FBS= 200 mg/dl, HbA1c = 8.5% and diabetes duration > 5years were enrolled from diabetic clinic of NMC after written informed consent. They were divided into control group and treatment group by sealed envelope technique. Control group received oral hypoglycemic drugs while treatment group received vitamin C 500 mg per orally BD with oral hypoglycemic drugs with advice of diet control and daily exercise. Patients were subjected to FBS, RBS and HbA1c at baseline and at the end of 90 days. SPSS version...