Role of Vitamin-C Supplementation in Type II Diabetes Mellitus (original) (raw)
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Iranian journal of diabetes and obesity (IJDO), 2023
Objective: Diabetes mellitus (DM) is a leading cause of morbidity and death worldwide. DM will affect 570.9 million people worldwide by 2025. The usefulness of vitamin C in improving diabetes control has been a point of contention. Materials and Methods: This clinical-trial double-blind study with control groups was conducted on 164 patients with type 2 diabetes mellitus (T2DM). The intervention group received 1000 mg of oral vitamin C daily, and a placebo was administered to the controls. To analyze the obtained data, one-way ANOVA was used in SPSS software (version 20). A P< 0.05 was considered statistically significant. Results: Fasting blood sugar (FBS), hemoglobin A1c (HbA1C), triglyceride (TG), and high-density lipoprotein (HDL) were improved significantly in the intervention group (P< 0.05), while the low-density lipoprotein (LDL) and cholesterol were unaffected (P> 0.05). HbA1C and LDL levels in the control group increased significantly (P< 0.05). Meanwhile, this group's HDL levels decreased considerably. Conclusion: Our findings support the consumption of vitamin C to complement the primary treatment for DM. According to our results, vitamin C provides a clear benefit over a placebo in the treatment of diabetic patients' serum parameters.
Family Medicine & Primary Care Review
Background. Diabetes mellitus (DM) is a metabolic disorder caused by many factors and related to serious complications. Diabetes mellitus includes oxidative stress and inflammation, in addition to hyperglycemia and resistance to insulin. Objectives. This study aimed to evaluate the effect of supplementation with vitamin C on blood glucose control and body mass index in type 2 diabetic patients of the family medicine outpatient clinic in Suez Canal University, Ismailia, Egypt. Material and methods. This was a double-blind, randomized, controlled clinical trial. Sixty patients (n = 60) were distributed randomly into two groups: the intervention group (on 1 g of vitamin C orally for 12 weeks), and the control group (on a placebo for the same period). Only 55 patients completed the study (28 in the intervention group and 27 in the control group). Glycated hemoglobin (HbA 1C %) and body mass index (BMI) were assessed at the beginning and after 12 weeks. Results. the Hba 1C percentage significantly decreased in the intervention group, supplemented with vitamin C, after 12 weeks as compared to the placebo group. The body mass index did not change significantly after the intervention. The intervention group had 75% glycemic improvement, while only 33.3% of the subjects improved in the control group. Absolute risk reduction (ARR) was 42%, the number of patients in need of treatment (NNT) was 2.38, the relative risk (RR) was 0.37, and the relative risk reduction (RRR) was 62%. Conclusions. Patients with type 2 diabetes may benefit from adding vitamin C to their routine management to control blood glucose.
The Effect of Vitamin C on the Metabolic Parameters of Experimental Diabetes Mellitus
American Journal of Pharmacology and Toxicology, 2007
The role of vitamin C on diabetes mellitus is unknown. The purpose of this study was to examine the effect of oral administration of vitamin C on some of the metabolic parameters of diabetic rats. Diabetes was induced by intraperitoneal injection of STZ (60 mg kg¯1 body weight at 12 weeks of age). Vitamin C (10, 50, 100 mg kg¯1 body weight) was administered orally for a period of four weeks to normal and diabetic male Wistar rats. In some experiments vitamin C was given either before or after the induction of diabetes mellitus. Glucose tolerance test (GTT) was performed on fasted normal, diabetic and vitamin C-treated rats at the end of the experimental period. Blood sugar level and weight were also recorded on a weekly basis for each rat in different groups. Vitamin C significantly (p<0.05) reduced blood glucose level and decreased weight gain in experimental diabetes mellitus at all doses when compared to untreated rats. This beneficial effect of vitamin C on the hyperglycemia of diabetic rats was dose-dependent. Moreover, vitamin C also improved GTT in diabetic rats compared to untreated diabetic rats. In conclusion, vitamin C may play a role in insulin metabolism and thus be a useful adjuvant therapy in diabetes mellitus.
Acibadem Universitesi Saglik Bilimleri Dergisi
Eksojen antioksidan takviyesinin, diyabetin mikro ve makrovasküler komplikasyonlarına karşı faydalı olabileceği bilinmektedir. Bu çalışmada C vitamini desteğinin, diyabetik ratlarda, kronik hiperglisemiye bağlı olarak bozulan insülin sekresyonu, hiperlipidemi, oksidatif stres ve paraoksonaz-1 enzim (PON1) aktivitesi üzerine etkilerinin araştırılması amaçlanmıştır. Bu amaçla, yirmi dört adet Wistar albino cinsi rat C, DC ve DCC grupları olarak 3 gruba ayrıldı. DC ve DCC grubundaki ratlarda, tek doz streptozotosin enjeksiyonu ile diyabet oluşturuldu (45 mg/kg). C ve DC grubundaki ratlar standart rat yemi (C vitamini içermeyen) ile beslenirken, DCC grubundaki ratlar 200 mg/kg dozunda C vitamini ile desteklenmiş deneysel yemle beslendi. Elde edilen bulgulara göre, C grubundaki ratların sekiz haftalık deney süresinin sonunda diyabetik ratlara göre daha az yem ve su tükettiği görüldü (p
Effects of vitamins C and D in type 2 diabetes mellitus
Nutrition and Dietary Supplements, 2015
Scurvy and rickets are largely considered historical diseases in developed countries. However, deficiencies in vitamins C and D are re-emerging due to increased consumption of processed foods and reduced fresh foods in the Western diet, as well as to an indoor sedentary lifestyle away from sun exposure. These dietary and lifestyle factors also predispose one to diabetes and metabolic syndrome. Our understanding of the potential roles of vitamin C (an antioxidant) and vitamin D (a biologically active hormone) in disease is increasing. In this review, we present observational, interventional, and mechanistic studies that examine the potential links between vitamins C and D in reversing defects in glucose homeostasis and the prevention of type 2 diabetes. Studies suggest an association between vitamin C deficiency and diabetes. An association between vitamin D and insulin resistance has been well described; however, the role of vitamin C and D supplementation in diabetes and its prevention requires further controlled trials.
International Journal of Innovation and Applied Studies, 2017
Diabetes mellitus is a group of metabolic disorders characterized by hyperglycemia. Intakes of vitamin C, Magnesium, Chromium, fiber and physical activity can help normalizing blood glucose level so as to prevent hyperglycemia. The aim of this study is to find out particular relations between vitamin C, Magnesium, Chromium, fiber, as well as physical activity and blood glucose levels in patients with diabetes mellitus at Dr. M. Yunus Hospital Bengkulu. This study was cross sectional approach. Sample population is Diabetes Mellitus Type II. Sampling is performed using purposive sampling with 50 samples. Intake data were obtained through 2 x 24 hours food recall form and PAL form. Data were analyzed using correlation regression and multiple linear regression. There were significant correlations between intakes of vitamin C (p = 0.001), Magnesium (p = 0.027), fiber (p = 0.028), physical activity (p = 0.001) and random blood glucose levels in patients with Diabetes Mellitus Type II. Con...
Nutrients
Vitamin C (ascorbate) is an essential micronutrient in humans, being required for a number of important biological functions via acting as an enzymatic cofactor and reducing agent. There is some evidence to suggest that people with type 2 diabetes mellitus (T2DM) have lower plasma vitamin C concentrations compared to those with normal glucose tolerance (NGT). The aim of this study was to investigate plasma vitamin C concentrations across the glycaemic spectrum and to explore correlations with indices of metabolic health. This is a cross-sectional observational pilot study in adults across the glycaemic spectrum from NGT to T2DM. Demographic and anthropometric data along with information on physical activity were collected and participants were asked to complete a four-day weighed food diary. Venous blood samples were collected and glycaemic indices, plasma vitamin C concentrations, hormone tests, lipid profiles, and high-sensitivity C-reactive protein (hs-CRP) were analysed. A total of 89 participants completed the study, including individuals with NGT (n = 35), prediabetes (n = 25), and T2DM managed by diet alone or on a regimen of Metformin only (n = 29). Plasma vitamin C concentrations were significantly lower in individuals with T2DM compared to those with NGT (41.2 µmol/L versus 57.4 µmol/L, p < 0.05) and a higher proportion of vitamin C deficiency (i.e. <11.0 µmol/L) was observed in both the prediabetes and T2DM groups. The results showed fasting glucose (p = 0.001), BMI (p = 0.001), smoking history (p = 0.003), and dietary vitamin C intake (p = 0.032) to be significant independent predictors of plasma vitamin C concentrations. In conclusion, these results suggest that adults with a history of smoking, prediabetes or T2DM, and/or obesity, have greater vitamin C requirements. Future research is required to investigate whether eating more vitamin C rich foods and/or taking vitamin C supplements may reduce the risk of progression to, and/or complications associated with, T2DM.
Preventive Medicine, 1997
Background. Persons with non-insulin-dependent diabetes mellitus (NIDDM) are at increased risk for cardiovascular disease, partly due to concomitant worsening of traditional risk factors including dyslipidemia and hypertension. Based on evidence from small, controlled clinical trials, we hypothesized that increased intake of vitamin C would be associated with improved cardiovascular disease (CVD) risk factor status among community-dwelling persons with NIDDM. Methods. In separate but parallel statistical analyses, hypotheses were evaluated among persons with NIDDM confirmed by WHO criteria from the Insulin Resistance Atherosclerosis Study (IRAS, n = 520) and from the San Luis Valley Diabetes Study (SLVDS, n = 422). For IRAS, diet and vitamin supplement use was assessed by food frequency interview and for SLVDS, by 24-hr dietary recall interview. Results. Mean vitamin C intake (mg/day) was 275 for IRAS and 133 for SLVDS, including supplements. In cross-sectional regression models from each data set, vitamin C intake was not associated with systolic or diastolic blood pressure nor with HDL-C, LDL-C, or triglycerides (P values >0.10; adjusted for calories, demographic and lifestyle variables, obesity, diabetes duration, and medications). In prospective analyses including 285 SLVDS participants, baseline vitamin C intake was not related to any of these CVD risk factors measured an average of 4 years later nor to change in CVD risk factor status during the follow-up period. Conclusions: We conclude that, across a wide range of intake, vitamin C does not appear to be associated with improved CVD risk factor status among community-dwelling persons with diabetes.
American Journal of Physiology-Heart and Circulatory Physiology, 2005
Endothelial dysfunction is a hallmark of Type 2 diabetes related to hyperglycemia and oxidative stress. Nitric oxide-dependent vasodilator actions of insulin may augment glucose disposal. Thus endothelial dysfunction may worsen insulin resistance. Intra-arterial administration of vitamin C improves endothelial dysfunction in diabetes. In the present study, we investigated effects of high-dose oral vitamin C to alter endothelial dysfunction and insulin resistance in Type 2 diabetes. Plasma vitamin C levels in 109 diabetic subjects were lower than healthy (36 ± 2 μM) levels. Thirty-two diabetic subjects with low plasma vitamin C (<40 μM) were subsequently enrolled in a randomized, double-blind, placebo-controlled study of vitamin C (800 mg/day for 4 wk). Insulin sensitivity (determined by glucose clamp) and forearm blood flow in response to ACh, sodium nitroprusside (SNP), or insulin (determined by plethysmography) were assessed before and after 4 wk of treatment. In the placebo gr...
Asian Journal of Pharmaceutical and Clinical Research, 2020
Objectives: Diabetes mellitus (DM) is a spectrum of common metabolic disorders, arising from a variety of pathogenic mechanisms resulting in hyperglycemia that causes chronic micro-and macro-vascular complications. Vitamin C is structurally similar to glucose and can replace it in many chemical reactions and thus is effective in the prevention of non-enzymatic glycosylation of proteins. Hence, the present study taken up to see the effect of supplementation of Vitamin C on blood glucose and glycosylated hemoglobin (HbA1c) along with metformin in experimentally-induced diabetic rabbits. Methods: Twenty-four adult New Zealand white rabbits (1.5-2.5 kg) were divided into four groups, each containing six rabbits. Group 1: Normal control (distilled water); Group 2: Metformin (23.33 mg/kg) is given orally; Group 3: Metformin (23.33 mg/kg) plus Vitamin C 250 mg are given orally; and Group 4: Metformin (23.33 mg/kg) plus Vitamin C 500 mg are given orally. Animals were treated for 30 days. The blood samples were collected on days 0 and 30 from the marginal ear vein of rabbits for the estimation of blood glucose and HbA1c levels. Results: Statistically analyzed by ANOVA test followed by post hoc Tukey's test using GraphPad Prism software. Results shown that Vitamin C 500 mg oral supplementation with metformin had very highly significantly reduced HbA1c levels by 40.12% (p = 0.0001***) and blood glucose levels by 49.12% (p = 0.0003***), whereas Vitamin C 250 mg oral supplementation with metformin also significantly reduced HbA1c levels by 25.49% (p = 0.0001***) and blood glucose levels by 42.95% (p = 0.0026**) when compared to metformin alone, which reduced HbA1c levels by 22% (p = 0.0001***) and blood glucose levels by 39.58% (p = 0.0001***). Conclusion: Oral supplementation of Vitamin C 500 mg/250 mg to the metformin was superior in reducing HbA1c levels and blood glucose levels compared to metformin alone in rabbits. Hence, Vitamin C oral supplementation may be helpful in lowering blood glucose levels and HbA1c levels and improving glycemic control in Type 2 DM.