Cochleo-vestibular clinical findings among drug resistant Tuberculosis Patients on therapy-a pilot study (original) (raw)
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Ototoxic hearing loss in the multi-drug resistant tuberculosis era
Journal of Islamabad Medical & Dental College, 2022
Objective: To determine the prevalence of hearing loss in tuberculosis patients using Ototoxic medicines and association with demographic and clinical variables. Methods: This cross sectional study recruited a sample of n= 65 diagnosed cases of tuberculosis on ototoxic chemotherapy, of both genders, aged 12 to 70 years, using non-probability convenience sampling. Study was conducted at Audiology Department of Civil Hospital Bahawalpur, over a period of 6 months from 1st May, 2019 to 31st October 2019. Screening was performed using medical history sheet, otoscopy and hearing assessment. Data collected was analyzed using SPSS- Version 21.0. Results: Results revealed a gender proportion of 43 (66.2%) males and 22(33.8%) females with mean age of 35.87+9.35 years. The prevalence of hearing loss was 23.1% (n=15) with mild hearing loss in 73.33% cases and moderate hearing loss 26.67%. Hearing loss was associated with drug, its duration and associated symptoms of tinnitus and vertigo with p...
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2013
Until now, examination of hearing loss degree in patients with MDRTB who received TB treatment has not been done. It is importantto prevent the effects of TB drugs against hearing loss or deafness. The results of the study on center TB hospitals at Beatrixoord inJanuary 1995 through July 2000 showed the prevalence of hearing loss due to ototoxic was quite large, 41%. This study is aretrospective descriptive study to obtain the incidence of hearing loss in MDRTB patients were performed at pulmonary division Dr.Soetomo Hospital Surabaya. The data was taken from patients visited from 1 January2009 through 31 December 2011. In general,there were 41 MDRTB patients with age range 22-60 years old. Mainly, patients were in the age group 31-40 years old(36.6%).Mostly they were treatment failure patients, 18 people(44%), relapsed patients as many as 13 people(31.6%), and inattentive 10people24.4%). From the anamnesis, hearing complaints obtained at 19 people(46.3%), and 22 people(53.7%) did n...
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A case of profound hearing loss developing in a patient with previously normal hearing following drug treatment for drug-resistant tuberculosis is reported. At present there are no specific audio-vestibular monitoring recommendations in most drug-resistant tuberculosis programs, and patients are at a high risk of developing irreversible ototoxicity before it is discovered. The report emphasizes the need for frequent and regular monitoring of the audio-vestibular system during treatment for drug-resistant and multi-drug resistant tuberculosis, the need for policy support for such monitoring and the need to develop innovative solutions to the financial and logistical challenges that such policies and monitoring would create.
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The importance of audiometric monitoring in patients with multidrug-resistant tuberculosis
Revista da Sociedade Brasileira de Medicina Tropical
A total of 771 cases of multidrug-resistant tuberculosis (MDR-TB) were reported in Brazil in 2014. Treatment of MDR-TB with aminoglycosides can produce serious side effects such as permanent and irreversible hearing loss, which occurs in 5-64% of cases, and severely compromise patient quality of life. The goal of this research was to evaluate auditory and vestibular side effects in patients treated for MDR-TB and to identify associations between these complaints and the type of aminoglycoside used. We performed a retrospective review of 599 medical records from patients with MDR-TB who were treated at the Hélio Fraga/Fiocruz Reference Center between 2006 and 2010. Cases without auditory or vestibular complaints and patients who were not treated with aminoglycoside drugs were excluded from the study. Of 164 eligible cases, 55 (33.5%) reported an auditory or vestibular complaint and medication was subsequently suspended, although hearing damage was not confirmed in all cases. Audiomet...
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African Health Sciences
Background: Hearing threshold changes occurred relative to baseline at both one and two weeks after onset of aminogly- coside therapy. Objectives: To assess changes in audiometric hearing thresholds between pre-treatment values and two weeks into therapy. To document observed changes, and occurrence of ototoxicity within the period. Methods: Prospective analytical cohort study on drug-resistant tuberculosis patients. Basic demographic parameters were taken. Three-point audiometric assessments within two weeks into therapy were done. Percentage of patients with ototoxic- ity were calculated. Pure tone threshold changes between the three audiometric values were compared. Results: Audiograms of 53 patients comprising 56.6% males; age range was 13 to 91 years. Both air and bone conduction hearing thresholds significantly worsened between baseline and one week into therapy (p=0.011, and 0.015 respectively), and between baseline and two weeks into therapy (p=0.003 and 0.042 respectively)....
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