Miniaturization through lab-on-a-chip: Utopia or reality for routine laboratories? A review (original) (raw)

Miniaturized total chemical analysis systems: A novel concept for chemical sensing

Sensors and Actuators B: Chemical, 1990

Following the trend towards smaller channel inner diameter for better separation performance and shorter channel length for shorter transport time, a modular construction of a miniaturized 'total chemical analysis system' is proposed. The theoretical performances of such systems based on flow injection analysis, chromatography and electrophoresis, are compared with those of existing chemical sensors and analysis systems.

Design Techniques for Microfluidic Devices Implementation Applicable to Chemical Analysis Systems

Process Analysis, Design, and Intensification in Microfluidics and Chemical Engineering, 2019

This chapter provides a guide for microfluidic devices development and optimization focused on chemical analysis applications, which includes medicine, biology, chemistry, and environmental monitoring, showing high-level performance associated with a specific functionality. Examples are chemical analysis, solid phase extraction, chromatography, immunoassay analysis, protein and DNA separation, cell sorting and manipulation, cellular biology, and mass spectrometry. In this chapter, most information is related to microfluidic devices design and fabrication used to perform several steps concerning chemical analysis, process preparation of reagents, samples reaction and detection, regarding water quality monitoring. These steps are especially relevant to lab-on-chip (LOC) and micro-total-analysis-systems (μTAS). μTAS devices are developed in order to simplify analytical chemist work, incorporating several analytical procedures into flow systems. In the case of miniaturized devices, the ...

Micro Total Analysis Systems: Microfluidic Aspects, Integration Concept and Applications

Topics in Current Chemistry, 1998

In this contribution three aspects of miniaturized total analysis systems (mTAS) are described and discussed in detail. First, an overview of microfabricated components for fluid handling is given. A description of the importance of sampling-and fluid-handling techniques is followed by details of microvalves, micropumps and micro flowchannels. Secondly, the problems associated with system integration are discussed. As a solution for the realization of microfluidic-and micro analysis systems, the concept of a planar mixed circuit board (MCB) as a platform for the integration of different components is described. In addition, the design, modeling and simulation, and realization of several components in the form of standard modules for integration on a MCB is described. As an illustration of the potential of this approach, the realization of a mTAS demonstrator for the optical detection of the pH change of a pH indicator, is presented. Finally, a number of different applications of mTAS are described, such as on-line process monitoring, environmental monitoring, biomedical and space applications and DNA-analysis.

Trends in miniaturized total analysis systems for point-of-care testing in clinical chemistry

Lab on a Chip, 2001

A currently emerging approach enables more widespread monitoring of health parameters in disease prevention and biomarker monitoring. Miniaturisation provides the means for the production of small, fast and easy-to-operate devices for reduced-cost healthcare testing at the point-of-care (POC) or even for household use. A critical overview is given on the present state and requirements of POC testing, on mTAS elements suited for implementation in future mTAS devices for POC testing and mTAS systems for the determination of clinical parameters. IBIS Technologies BV for the development and sales of SPRbased biosensors. In September 1998 he joined the MESA + Research Institute, University of Twente as senior scientist for the research and development of "lab on a chip" devices for bioanalytical/diagnostic applications.

Lab-on-chip systems for integrated bioanalyses

Essays in biochemistry, 2016

Biomolecular detection systems based on microfluidics are often called lab-on-chip systems. To fully benefit from the miniaturization resulting from microfluidics, one aims to develop 'from sample-to-answer' analytical systems, in which the input is a raw or minimally processed biological, food/feed or environmental sample and the output is a quantitative or qualitative assessment of one or more analytes of interest. In general, such systems will require the integration of several steps or operations to perform their function. This review will discuss these stages of operation, including fluidic handling, which assures that the desired fluid arrives at a specific location at the right time and under the appropriate flow conditions; molecular recognition, which allows the capture of specific analytes at precise locations on the chip; transduction of the molecular recognition event into a measurable signal; sample preparation upstream from analyte capture; and signal amplifica...

Miniaturized tools and devices for bioanalytical applications: an overview

Analytical and Bioanalytical Chemistry, 2009

This article presents an overview of various miniaturized devices and technologies developed by our group. Innovative, fast and cheap procedures for the fabrication of laboratory microsystems based on commercially available materials are reported and compared with well-established microfabrication techniques. The modules fabricated and tested in our laboratory can be used independently or they can be set up in different configurations to form functional measurement systems. We also report further applications of the presented modules e.g. disposable poly(dimethylsiloxane) (PDMS) microcuvettes, fibre optic detectors, potentiometric sensors platforms, microreactors and capillary electrophoresis (CE) microchips as well as integrated microsystems e.g. double detection microanalytical systems, devices for studying enzymatic reactions and a microsystem for cell culture and lysis.

Micro-and Nano-systems for Chemical/Bio-medical Analysis and Diagnostics

Procedia Engineering, 2012

This paper reports selected results of the MNS-DIAG research project. The project is aimed at facilitating access of research teams coming from academia to fully equipped CMOS/MEMS R&D and manufacturing line and thus allowing for inflow of innovative microdevice concepts and development of demonstrators. To address the important grand societal challenges related to well-being and health in the ageing society, the project has been focused on application of micro-and nano-systems for chemical/bio-medical analysis and diagnostics. Out of five demonstrators elaborated within the MNS-DIAG, three are shortly described here, namely, Lab-on-a-chip for oocytes characterization, Micromechanical biosensors array and Integrated MEMS detector for dynamic humidity measurement in medical applications.