KP-1212/1461, a nucleoside designed for the treatment of HIV by viral mutagenesis (original) (raw)
Lethal Mutagenesis of HIV with Mutagenic Nucleoside Analogs
Jue Zhang
Proceedings of The National Academy of Sciences, 1999
View PDFchevron_right
Evaluation of Anti-HIV-1 Mutagenic Nucleoside Analogues
Geraldine Laumond, Jean-christophe Paillart
Journal of Biological Chemistry, 2014
View PDFchevron_right
Mutation of HIV-1 Genomes in a Clinical Population Treated with the Mutagenic Nucleoside KP1461
Jeffrey Simpson
PLoS ONE, 2011
View PDFchevron_right
Anti-HIV nucleoside drugs: A retrospective view into the future
Marina Kukhanova
Molecular Biology, 2012
View PDFchevron_right
Pharmacology of current and promising nucleosides for the treatment of human immunodeficiency viruses
Selwyn Hurwitz
Antiviral Research, 2006
View PDFchevron_right
Nucleoside analogues previously found to be inactive against HIV may be activated by simple chemical phosphorylation
caleb nickson
Febs Letters, 1993
View PDFchevron_right
Current Use of Nucleoside Analogues in the Treatment of HIV Infection
Carlos Zala
Canadian Journal of Infectious Diseases, 1994
View PDFchevron_right
In Vitro Activity of Structurally Diverse Nucleoside Analogs against Human Immunodeficiency Virus Type 1 with the K65R Mutation in Reverse Transcriptase
Raymond Schinazi
Antimicrobial Agents and Chemotherapy, 2005
View PDFchevron_right
Chimeric human immunodeficiency virus type 1/type 2 reverse transcriptases display reversed sensitivity to nonnucleoside analog inhibitors
Albino Bacolla
Proceedings of the National Academy of Sciences, 1991
View PDFchevron_right
Selective pressure of a quinoxaline nonnucleoside inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) on HIV-1 replication results in the emergence of nucleoside RT-inhibitor-specific (RT Leu-74-->Val or Ile and Val-75-->Leu or Ile) HIV-1 mutants
Manfred Rösner
Proceedings of the National Academy of Sciences of the United States of America, 1996
View PDFchevron_right
Recent Advances in Antiviral Nucleosides
Giuseppe Gumina
Antiviral Nucleosides, 2003
View PDFchevron_right
5,6-Dihydro-5-aza-2′-deoxycytidine potentiates the anti-HIV-1 activity of ribonucleotide reductase inhibitors
Lauren Beach
Bioorganic & Medicinal Chemistry, 2013
View PDFchevron_right
Kinetics of inhibition of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase by the novel HIV-1-specific nucleoside analogue [2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]-3'-spiro-5 "- (4"-amino-1",2"-oxathiole-2",2"-dioxide)thymine (TSAO-T)
Ana San Felix
The Journal of biological chemistry, 1992
View PDFchevron_right
HIV-1 reverse transcriptase complex with DNA and nevirapine reveals non-nucleoside inhibition mechanism
Kalyan Das
Nature Structural & Molecular Biology, 2012
View PDFchevron_right
In vitro studies of the toxicity of nucleoside analogues used in the treatment of HIV infection
Oliver Flint
Toxicology in Vitro, 1994
View PDFchevron_right
In Vitro Antiretroviral Activity and In Vitro Toxicity Profile of SPD754, a New Deoxycytidine Nucleoside Reverse Transcriptase Inhibitor for Treatment of Human Immunodeficiency Virus Infection
P. McKenna, Brigitte Allard
Antimicrobial Agents and Chemotherapy, 2006
View PDFchevron_right
Novel Mechanism of Inhibition of HIV-1 Reverse Transcriptase by a New Non-nucleoside Analog, KM-1
Kenneth Johnson
Journal of Biological Chemistry, 2004
View PDFchevron_right
Antiretroviral nucleosides, deoxynucleotide carrier and mitochondrial DNA: evidence supporting the DNA pol γ hypothesis
Wendell Lewis
AIDS, 2006
View PDFchevron_right
Differential susceptibility of retroviruses to nucleoside analogues
Myra McClure
Antiviral chemistry & chemotherapy, 2001
View PDFchevron_right
1592U89, a novel carbocyclic nucleoside analog with potent, selective anti-human immunodeficiency virus activity
Devron Averett
Antimicrobial agents and chemotherapy, 1997
View PDFchevron_right
Phosphonated Nucleoside Analogues as Antiviral Agents
Ugo Chiacchio
Topics in Medicinal Chemistry, 2013
View PDFchevron_right
Fixed Conformation Nucleoside Analogs Effectively Inhibit Excision-proficient HIV-1 Reverse Transcriptases
Victor Marquez
Journal of Molecular Biology, 2005
View PDFchevron_right
4'Ethynyl Nucleoside Analogs: Potent Inhibitors of Multidrug-Resistant Human Immunodeficiency Virus Variants In Vitro
Hiroyuki Gatanaga
Antimicrobial Agents and Chemotherapy, 2001
View PDFchevron_right
Study of the Effects on DNA of Two Novel Nucleoside Derivatives Synthesized as Potential Anti-HIV Agents
Ahmed O Maslat
Drug and Chemical Toxicology, 2007
View PDFchevron_right
In Search of New Inhibitors of HIV-1 Replication: Synthesis and Study of 1-(2′-Deoxy-β-D-Ribofuranosyl)-1,2,4-Triazole-3-Carboxamide as a Selective Viral Mutagenic Agent
Roland Marquet, Jean-christophe Paillart
Nucleosides, Nucleotides and Nucleic Acids, 2007
View PDFchevron_right
Effects of the Δ67 Complex of Mutations in Human Immunodeficiency Virus Type 1 Reverse Transcriptase on Nucleoside Analog Excision
Tomozumi Imamichi
Journal of Virology, 2004
View PDFchevron_right
Cellular phosphorylation of anti-HIV nucleosides
Ioan Lascu
Journal of Biological …, 1996
View PDFchevron_right
Combination of a mutagenic agent with a reverse transcriptase inhibitor results in systematic inhibition of HIV-1 infection
Miguel Martinez
Virology, 2005
View PDFchevron_right
Discovery of Non‐Nucleoside Inhibitors of HIV‐1 Reverse Transcriptase Competing with the Nucleotide Substrate
Marco Radi
Angewandte …, 2007
View PDFchevron_right
Effects of the 67 Complex of Mutations in Human Immunodeficiency Virus Type 1 Reverse Transcriptase on Nucleoside Analog Excision
Paul L . Boyer
Journal of Virology, 2004
View PDFchevron_right
Toxicity of antiviral nucleoside analogs and the human mitochondrial DNA polymerase
As Ray
Journal of Biological …, 2001
View PDFchevron_right