Recent advances in the structural mechanisms of DNA glycosylases (original) (raw)
Emerging Roles of DNA Glycosylases and the Base Excision Repair Pathway
Brandt F Eichman
Trends in Biochemical Sciences, 2019
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The DNA glycosylase AlkD uses a non-base-flipping mechanism to excise bulky lesions
Rongxin Shi, Brandt F Eichman
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Structural Biology of the HEAT-Like Repeat Family of DNA Glycosylases
Brandt F Eichman
BioEssays, 2018
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Selective base excision repair of DNA damage by the non-base-flipping DNA glycosylase AlkC
Brandt F Eichman
The EMBO journal, 2017
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Structural insight into repair of alkylated DNA by a new superfamily of DNA glycosylases comprising HEAT-like repeats
Magnar Bjørås
Nucleic Acids Research, 2007
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Crosstalk of DNA glycosylases with pathways other than base excision repair
Cynthia McMurray
DNA Repair, 2007
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A New Protein Architecture for Processing Alkylation Damaged DNA: The Crystal Structure of DNA Glycosylase AlkD
Brandt F Eichman
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Focus on DNA Glycosylases—A Set of Tightly Regulated Enzymes with a High Potential as Anticancer Drug Targets
Joanna Timmins
International Journal of Molecular Sciences, 2020
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Excised damaged base determines the turnover of human N-methylpurine-DNA glycosylase
Rabindra Adhikari
Dna Repair, 2009
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New family of deamination repair enzymes in uracil-DNA glycosylase superfamily
Weiguo Cao
The Journal of biological chemistry, 2011
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Mutation of a Unique Aspartate Residue Abolishes the Catalytic Activity but Not Substrate Binding of the Mouse N-Methylpurine-DNA Glycosylase (MPG)
Sankar Mitra
Journal of Biological Chemistry, 2000
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Combining structural and bioinformatics methods for the analysis of functionally important residues in DNA glycosylases1,2 1Guest Editor: Miral Dizdaroglu 2This article is part of a series of reviews on “Oxidative DNA Damage and Repair.” The full list of papers may be found on the homepage of the...
Arthur Grollman
Free Radical Biology and Medicine, 2002
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Non-flipping DNA glycosylase AlkD scans DNA without formation of a stable interrogation complex
Magnar Bjørås
Communications Biology, 2021
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Strandwise translocation of a DNA glycosylase on undamaged DNA
Michael Zhang
2012
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Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA
John Tainer
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Identification and characterization of a human DNA glycosylase for repair of modified bases in oxidatively damaged DNA
Istvan Boldogh
Proceedings of the National Academy of Sciences of the United States of America, 2002
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Identification of a new uracil-DNA glycosylase family by expression cloning using synthetic inhibitors
Karl Haushalter
Current Biology, 1999
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Binding of Specific DNA Base-pair Mismatches by N-Methylpurine-DNA Glycosylase and Its Implication in Initial Damage Recognition
Sankar Mitra
Journal of Molecular Biology, 2002
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Mutational analysis of the damage-recognition and catalytic mechanism of human SMUG1 DNA glycosylase
Katsuo Katayanagi
Nucleic Acids Research, 2004
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Structure of a DNA glycosylase that unhooks interstrand cross-links
Brandt F Eichman
Proceedings of the National Academy of Sciences, 2017
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3-methyladenine DNA glycosylases: structure, function, and biological importance
Tom Ellenberger, Michael Wyatt
BioEssays, 1999
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5-Hydroxy-5-methylhydantoin DNA lesion, a molecular trap for DNA glycosylases
Pierre Aller
Nucleic Acids Research, 2011
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A discontinuous DNA glycosylase domain in a family of enzymes that excise 5-methylcytosine
Rafael Vizcaino Ariza
Nucleic Acids Research, 2010
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Searching for DNA Lesions: Structural Evidence for Lower- and Higher-Affinity DNA Binding Conformations of Human Alkyladenine DNA Glycosylase
Leona Samson
Biochemistry, 2012
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The type of DNA glycosylase determines the base excision repair pathway in mammalian cells
Eugenia Dogliotti
Journal of Biological …, 1999
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An unprecedented nucleic acid capture mechanism for excision of DNA damage
Thomas Spratt, Brandt F Eichman
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A New Family of HEAT-Like Repeat Proteins Lacking a Critical Substrate Recognition Motif Present in Related DNA Glycosylases
Brandt F Eichman
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Conformational Dynamics of Damage Processing by Human DNA Glycosylase NEIL1
Inga Grin
Journal of Molecular Biology, 2019
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Active destabilization of base pairs by a DNA glycosylase wedge initiates damage recognition
Arthur Grollman
Nucleic acids research, 2015
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Crystal Structure and Mutational Analysis of Human UraciI-DNA Glycosylase: Structural Basis for Specificity and Catalysis
John Tainer
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Reaction Intermediates in the Catalytic Mechanism of Escherichia coli MutY DNA Glycosylase
John Tainer
Journal of Biological Chemistry, 2004
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