Serum ferritin as a biomarker in hematological conditions (original) (raw)
Related papers
2018
Objective: To evaluate serum ferritin levels in children less than five years as screening measure for iron deficiency anemia (IDA). Subjects and Methods: A cross-sectional study was conducted at Benazir Bhutto Hospital Rawalpindi from 1st March 2010 to 31st Jan 2011. A simple random sampling technique was adopted for study proceedings. Fifty children of less than five (5) years of age were enrolled in the study. The study population included children, aged less than five presenting at pediatrics outpatient department. The children with known hematological abnormality, infection, inflammation were excluded from the study. Blood complete picture for hemoglobin and serum ferritin level estimation were the diagnostic tools used and correlated afterwards. Data were collected and entered in Statistical Package for Social Sciences (SPSS, version 16) for analysis. Descriptive statistics were calculated. Chi-square test was applied for evaluation and calculation of significance in each of t...
Clinical Importance of Determining Serum Ferritin. Establishing Reference Values
The diagnosis of iron deficiency anemia is based on the determination of serum hemoglobin (iron in red blood cells), serum iron (iron in circulation) and ferritin (iron in storage). For an accurate interpretation of laboratory test results and their qualification as normal or pathological, it is essential that each laboratory should establish its own reference intervals for the population it serves. This study defines reference intervals for serum ferritin in children and teenagers using ferritin determinations on a significant number of patients (hospitalized or outpatients). Materials and methods: The study was conducted in the Sibiu Clinical Pediatric Hospital using electronic laboratory data archive from January-December 2010. Serum ferritin measurements have been made on a sample of 600 patients by means of the MiniVidas, Biomerieux analyzer. Data analysis has been performed with the SPSS program using robust method to get 2.5 and 97.5 percentiles. Results and conclusions: The ...
2020
Objective: To evaluate the effect of intravenous Iron therapy on serum Ferritin and Haemoglobin levels in children with iron deficiency anaemia. Study Design: Cross sectional study. Place and Duration of Study: Combined Military Hospital (CMH), Quetta, from Aug 2015 to Jul 2017. Methodology: Patients of either sex with age 1 to 12 years with iron deficiency anemia were included in the study. Sampling technique was Consecutive non-probability purposive sampling. Iron deficiency anemia was diagnosed on the basis of mean corpuscular volume (MCV), Hemoglobin (hb) concentration and serum ferritin. Intravenous iron therapy was given to all patients included in the study. Patients were followed up after 4 weeks. Paired t-test was applied for pre and post therapy HB and serum Ferritin. A p-value ≤0.05 was considered significant. Results: Total number of patients included in the study was 55. Out of total patients male were 35 (64%) and female were 20 (36%). Mean age of patients was 2.48 ± 1...
Serum Ferritin Levels In Patients with Sickle Cell Anaemia atthe Kenyatta National Hospital
Background: The iron levels in Sickle Cell Anaemia (SCA) is thought to be increased because of the repeated red cell transfusion, haemolysis with subsequent recycling and accumulation of iron. Red cell transfusion is used frequently to prevent and treat the complications of sickle cell disease. Studies have shown that the changes in iron status that results from such therapy is associated with significant morbidity and mortality. Thisstudy examined the serum ferritin as a marker of iron levels in patients with sickle cell disease who receive chronic red blood cell transfusion. Objective: The aim of this study was to assess the status of serum iron levels by measurement of serum ferritin in patients with sickle cell Anaemia managed at Kenyatta National Hospital. Setting: The study was carried out at the Kenyatta National Hospital Haematology clinic. Design: Cross-sectional descriptive study Materials and methods: This study enrolled 80 patients with sickle cell anaemia. History and physical examination was done and recorded on study proforma. Samples of blood were then drawn for serum ferritin, full blood count including peripheral blood film. Serum ferritin was assessed using enzyme immunoassay sandwich method with a final fluorescent detection (ELFA) kits. Blood counts were done using the haematology cell counter (CELL-DYN 1300) whiles the peripheral blood films were stained using May Grunewald Giemsa method. Quality control measures were observed in all tests performed by adhering to reagent manufacturers' guidelines and standard specimen handling/laboratory operating procedures, to ensure validity of results. Results: Eighty clinically stable patients with SCA were studied. Thirty-three were males (41.3%) while Forty-seven were females (58.7%). The mean age in the study population was 19.7±5.5 years with the youngest being 13years and the oldest 37years. Serum ferritin mean 939.25±668ng/ml, was found to be significantly elevated in 56 (70.5%) of our study subjects while 24 had normal SF levels and none of them had low SF. Twenty-five (31.3%) who had very high SF, above 1000ng/ml, had also been transfused a mean of 15±8.2 units of blood. There was a significant association between SF and the number of units of blood transfused, p=<0. 001.There was no demonstrable significant association between SF and age, sex or red cell parameters. Conclusion: This study revealed high serum ferritin in majority 70.5% of our patients with SCA. None of our patients had low SF. Very high serum ferritin, more than 1000ng/ml was observed in patients who received ≥15 units of blood over a period of five years. There was a significant association between serum ferritin levels and number of blood transfusions. Annual serum ferritin measurements are recommended to determine the iron status to institute prompt therapeutic measure of iron chelation.
Serum ferritin to detect iron deficiency in children below five years of age
Paediatrica Indonesiana, 2013
Background cognitive and motor development of children until the age of is recommended and serum ferritin has been proposed as an Objective To assess the diagnostic accuracy of serum ferritin for Methods This cross-sectional, diagnostic study was conducted in for serum ferritin level use as a diagnostic tool was determined by receiver operator curve. Results Conclusions The diagnostic value of serum ferritin levels is below five years of age. [Paediatr Indones. 2013;53:150-4.].
International Journal of Contemporary Pediatrics, 2019
Background: Nutritional anemia is a worldwide problem with the highest prevalence in the developing countries. One of the most vulnerable groups is 6-24 months of age. NFHS-3 survey shows that the incidence of anemia in children aged 6-35 months is 79.2% with 72.7% in urban areas and 81.2% in rural areas. First stage of iron deficiency is depletion of iron stores, which is reflected by decreased serum ferritin levels and increased total iron binding capacity (TIBC) levels. The objective of this study was to detect presence of iron deficiency in children even before clinical appearance of anemia by measuring serum ferritin levels.Methods: The study was conducted from March 2017 to November 2017 in the Department of Pediatrics of Sir Sayajirao Gaekwad General Hospital, a tertiary level hospital and government medical college, Vadodara. A cross sectional study was done in which a total of 111 asymptomatic infants and toddlers in age group of 6-24 months presenting to well-baby clinic w...
Clinical chemistry, 1991
We determined serum ferritin, C-reactive protein (CRP), fibrinogen, and the erythrocyte sedimentation rate (ESR) in 73 patients with anemia of chronic disease. Nomograms of CRP, ESR, or fibrinogen vs ferritin concentrations were constructed and used to estimate the iron store in bone marrow. Iron stores estimated from the nomograms were compared with the results of staining cytological bone marrow smears for iron, the reference method for evaluating iron in bone marrow. In contrast to the results of Witte et al. (Clin Chem 1985;31:1011; Am J Clin Pathol 1986;85:202-6 and 1988;90:85-7), we observed that nomograms of CRP, fibrinogen, or ESR (i.e., acute-phase reactants not influenced by changes in iron metabolism) vs ferritin are not suitable to correct for the acute-phase component of changes in ferritin concentrations. For ferritin concentrations less than 70 micrograms/L, we found that iron deficiency, as judged from bone marrow iron stain, apparently was always present.
Serum ferritin in thalassemia intermedia
Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion, 2014
Serum ferritin is a useful monitoring tool for iron overload in thalassemia major. In resource poor settings access to modalities for assessment of iron overload are limited. This study was undertaken to assess the efficiency and usefulness of serum ferritin level in thalassemia intermedia (TI) patients. This was a cross sectional observational study. Seventy seven TI patients attending the pediatric hematology clinic were included. Fasting blood sample was taken from each patient in iron free vials for iron studies. Serum ferritin was estimated by immunometric enzyme immunoassay using Orgentec GmbH kits. Mean age of patients evaluated was 10.9 ± 5.03 (3-26) years. The mean age at diagnosis was 4.21 ± 2.3 (0.8-11) years. Mean serum ferritin was 486.54 ± 640.0 ng/ml (15-4,554). Thirty two (41.5 %) patients had a ferritin value of ≥500 ng/ml. Nine patients had a serum ferritin of ≥1,000 ng/ml. Three of the subjects with a ferritin >1,000 ng/ml had never received a blood transfusion...
IMC Journal of Medical Science
Background and objective: Children in the developing world are vulnerable to iron deficiency (ID) and iron deficiency anemia (IDA) because they grow fast and consume diets low in iron. Thus, this study assessed anemia in children aged 6 - 12 years in rural Nigeria, using hematological indices and serum ferritin as diagnostic tools. Materials and methods: This cross-sectional study was carried out in two primary schools in Kumin Masara Kataf village in Kaduna state, Nigeria. School children aged 6 - 12 years were enrolled. Personal information and laboratory data were collected. Hemoglobin and serum ferritin concentration was estimated to determine anemia and iron status. Data analysis was done using IBM-SPSS Inc., Chicago, IL, USA, version-25.0. Results: A total of 191 school-age children aged 6 - 12 years were enrolled in the study. The overall serum ferritin was 16.51±5.20 mg/L, but the children aged 6 - 9 years had significantly (p<0.05) higher serum ferritin (17.23±5.57 mg/L)...