Human prolactin (hPRL) antagonists inhibit hPRL-activated signaling pathways involved in breast cancer cell proliferation (original) (raw)

The role of prolactin in human breast cancer Review

Hamza Mujagic

Biochemia Medica

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Involvement of prolactin in breast cancer: redefining the molecular targets11Abbreviations: PRL, prolactin; PRLR, PRL receptor; GH, growth hormone; JAK, Janus kinase; STAT, signal transducer and activator of transcription; MAPK, Mitogen–activated protein kinase; PI 3-K, Phosphoinositide 3-kinase;...

Vincent Goffin

Experimental Gerontology, 2000

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Should prolactin be reconsidered as a therapeutic target in human breast cancer?

Vincent Goffin

Molecular and Cellular Endocrinology, 1999

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Ovarian hormones are not required for PRL-induced mammary tumorigenesis, but estrogen enhances neoplastic processes

Lisa Arendt

Journal of Endocrinology, 2009

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Prolactin and human breast cancer: a review

tvrtko bosnic

European Journal of Cancer, 1979

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The role of prolactin in human breast cancer

Hamza Mujagic

2009

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Prolactin Drives Estrogen Receptor-α-Dependent Ductal Expansion and Synergizes with Transforming Growth Factor-α to Induce Mammary Tumors in Males

Lisa Arendt

The American Journal of Pathology, 2008

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Expression of Prolactin and Its Receptor in Human Breast Carcinoma 1

Jean-jacques Lebrun

Endocrinology, 1997

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Prolactin as a local growth promoter in patients with breast cancer: GCRI experience

Nandita Ghosh

European Journal of Surgical Oncology (EJSO), 2000

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Prolactin Drives Estrogen Receptor- -Dependent Ductal Expansion and Synergizes with Transforming Growth Factor- to Induce Mammary Tumors in Males

Lisa Arendt

Amer J Pathol, 2008

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Impaired Turnover of Prolactin Receptor Contributes to Transformation of Human Breast Cells

A. Plotnikov

Cancer Research, 2009

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Effects of Mammary Surgery on Prolactin Secretion in Common and in Triple Negative Breast Cancer Patients

Roberto Trampetti

ARC Journal of Gynecology and Obstetrics

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Stabilization of prolactin receptor in breast cancer cells

Natalie Minkovsky

Oncogene, 2005

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Prolactin receptor expression in gynaecomastia and male breast carcinoma

Mariana Mesquita

Histopathology, 2008

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TRIENNIAL LACTATION SYMPOSIUM: Prolactin: The multifaceted potentiator of mammary growth and function

Josephine Trott

Journal of Animal Science, 2012

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Increased Expression of Prolactin Receptor Gene Assessed by Quantitative Polymerase Chain Reaction in Human Breast Tumors Versus Normal Breast Tissues

Jean-françois Martini

The Journal of Clinical Endocrinology & Metabolism, 1998

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Loss of mammary epithelial prolactin receptor delays tumor formation by reducing cell proliferation in low-grade preinvasive lesions

James Kench

Oncogene, 2007

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The Expression of Prolactin Receptors in Benign Breast Tumors Is Not Associated with Serum Prolactin Level

Roman Moskalenko

Journal of Clinical Medicine, 2021

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Progesterone receptors (PR) mediate STAT actions: PR and prolactin receptor signaling crosstalk in breast cancer models

Laura Mauro

The Journal of Steroid Biochemistry and Molecular Biology, 2017

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Distribution of prolactin receptors suggests an intraductal role for prolactin in the mouse and human mammary gland, a finding supported by analysis of signaling in polarized monolayer cultures

Saudade Andre

Cell and Tissue Research, 2011

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Identification of a gain-of-function mutation of the prolactin receptor in women with benign breast tumors

Vincent Goffin

Proceedings of the National Academy of Sciences, 2008

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Suppression of Breast Cancer by Small Molecules That Block the Prolactin Receptor

Eric Hugo

Cancers

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Prolactin induces ERα-positive and ERα-negative mammary cancer in transgenic mice

Lisa Arendt

Oncogene, 2003

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Prolactin Signaling in Mammary Gland Development

Xiuwen Liu

Journal of Biological Chemistry, 1997

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A 20-Year Prospective Study of Plasma Prolactin as a Risk Marker of Breast Cancer Development

Xuehong Zhang

Cancer Research, 2013

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Activation of the unliganded estrogen receptor by prolactin in breast cancer cells

Ana Aranda

Oncogene, 2009

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Local over-expression of prolactin in differentiating mouse mammary gland induces functional defects and benign lesions, but no carcinoma

Vincent Goffin

Journal of Endocrinology, 2006

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Biological Significance of Prolactin in Gynecologic Cancers

Anna Lokshin, Vera Levina

Cancer Research, 2009

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Expression of prolactin receptors in normal canine mammary tissue, canine mammary adenomas and mammary adenocarcinomas

Erika Michel, Iris Reichler

BMC Veterinary Research, 2012

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Prolactin as a mammalian mitogen and tumor promoter

Charles Putnam

Advances in Enzyme Regulation, 1988

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Prolactin drives estrogen receptor-alpha-dependent ductal expansion and synergizes with transforming growth factor-alpha to induce mammary tumors in males

Lisa Arendt

The American journal of pathology, 2008

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Transcriptional and spatiotemporal regulation of prolactin receptor mRNA and cooperativity with progesterone receptor function during ductal branch growth in the mammary gland

Josephine Trott

Developmental Dynamics, 2001

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The Role of Prolactin Receptor in GH Signaling in Breast Cancer Cells

John Langenheim

Molecular Endocrinology, 2013

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Prolactin-induced mouse mammary carcinomas model estrogen resistant luminal breast cancer

Lisa Arendt

Breast Cancer Research, 2011

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Prolactin receptor gene transcriptional control, regulatory modalities relevant to breast cancer resistance and invasiveness

Maria Dufau

Frontiers in Endocrinology

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