Squamous cell carcinoma of the nail apparatus in the population of Northern Poland (original) (raw)
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Cureus, 2021
The nail apparatus is a complex area with great functional and cosmetic importance. The appearance of tumors is rare, frequently misdiagnosed with delaying the diagnosis. A series of cases is presented, where squamous cell carcinoma of nail apparatus underwent resection and reconstructive surgery in a relatively short time from their diagnosis, with a good oncological, functional, and cosmetic result.
Squamous cell carcinoma of the nail bed: a case report
International Surgery Journal, 2015
Squamous cell carcinoma of the nail bed is rare and commonly diagnosed late. Presentation is not specific and diagnosis rests on biopsy of the lesion. This condition can be easily misdiagnosed, especially if there is preceding trauma. We are also reporting such case involving the thumb. A 70 years old male patient presented at OPD with complaints of pain and ulcer over left thumb since last 4 months. Patients had lost his thumb nail 6 month back and since then was treated on Ayurvedic treatment. Patient does not give a history of trauma. Biopsy of the ulcer revealed Squamous Cell Carcinoma. His X-ray did not reveal any infiltration and hence a distal phalanx amputation of thumb was performed. Patient had an uneventful post-operative course and on 9 months follow up showed no recurrence. Rare still subungual squamous cell carcinoma should be considered early in lesions around the nail that fail to resolve after adequate conservative management. Early detection helps change surgical treatment from amputation to more preserving techniques like Moh's or wide local flap reconstruction.
Squamous cell carcinoma of the nail bed: a clinicopathological study of 12 cases
British Journal of Dermatology, 1990
Twelve cases were reviewed of squamous cell carcinoma of the nail bed, with emphasis on the aetiological role of human papiUomavirus (HPV) infection and radiation damage. Using a hybridization technique, similar HPV genomes were detected in a uterine cervical neoplasia and a subungual squamous cell carcinoma in the same patient.
Important malignant and new nail tumors
The nail apparatus is an integral part of the functional unit of the digital tip. Although overall uncommon, all cells and tissues occurring in this area can give rise to neo-plastic lesions. Given the special anatomical location, such tumors frequently show morphological and symptom-related differences compared to similar lesions located elsewhere on the skin. Though particularly threatening, there is often a substantial delay in the diagnosis of Bowen's disease, ungual squamous cell carcinoma, and melanoma. Nevertheless, local excision with sufficient surgical margins is usually sufficient and superior to amputation of the distal phalanx. In recent years, a number of nail-specific tumors have been described. Tumors such as onychomatricoma, ony-chocytic matricoma, onychocytic carcinoma, and onychopapilloma originate from the nail matrix. Onycholemmal cysts, onycholemmal horn, and the proliferating onycholemmal tumor are characteristic nail bed tumors. Onycholemmal carcinoma is a slowly growing low-grade malignancy. Using modern diagnostic methods, careful examination – including biopsy and histopathology – of nail changes not responding to conservative treatment will help identify nail-specific neoplasms and prevent the progression of malignant nail tumors.
Squamous cell carcinoma of the lateral nail fold
The Journal of Hand Surgery: Journal of the British Society for Surgery of the Hand, 2006
The digital nail complex is occasionally involved by squamous cell carcinoma. The published literature has either been indiscriminating of the site of origin of this tumour within the nail complex or has concentrated attention on the nail bed as the site of pathology. Tumours originating in the lateral nail fold can be clearly differentiated from those of the nail bed itself. This study identifies six cases of squamous cell carcinoma arising in the lateral nail fold. While surgical convention remains to amputate the digital tip for squamous cell carcinoma of any part of the nail complex, the dermatological literature identifies that local surgery can be curative for these tumours, when presenting early and without bone involvement, although offering no discussion of reconstruction. Reconstruction is desirable and methods of achieving this following local excision of lateral nail fold tumours are illustrated in this series.
Skin Appendage Disorders
Introduction: Onycholemmal carcinoma (OC) is a rare subtype of squamous cell carcinoma (SCC) that originates from the epithelium of the nail bed. It is characterized by distinct histopathologic features including small clusters of atypical squamous epithelium devoid of a granular layer, with abrupt onycholemmal keratinization. Case Presentation: We present a case of a 75-year-old male with right thumbnail onycholysis, yellow-green nail plate discoloration, as well as bleeding and purulence of the lateral nail fold. Histopathologic evaluation revealed high-grade squamous dysplasia, small clusters of severely atypical epithelial cells, and a pattern of abrupt keratinization consistent with the diagnosis of SCC carcinoma with onycholemmal features. GMS and PAS staining indicated concomitant onychomycosis. Pathologic analysis also disclosed residual SCC and concomitant amyloidosis, possibly light chain related and hence reflective of his underlying multi-organ lymphoplasmacytic lymphoma...
Melanocytic Lesions of the Nail Unit
Dermatopathology
Melanocytic lesions of the nail unit are traditionally classified as follows: melanocytic activation, lentigo, nevi, and melanoma. Undoubtedly, melanoma is the most important malignant tumor of the nail unit. Differentiating nail unit melanoma from other melanocytic lesions is often difficult both clinically and histopathologically. This article will first describe the histology of the nail unit, followed by a brief summary of clinical and histopathological features as well as differential diagnosis of melanocytic lesions of the nail unit.
Squamous cell carcinoma of the toenail bed: a case report
Global Dermatology, 2016
Subungual Squamous Cell Carcinoma (SCC) is the most common malignancy affecting the nail bed. About 150 cases of subungual SCC have been reported in the literature. It usually involves the thumb, the index finger and only rarely, the toes. Subungual SCC runs an indolent course and may present with minimal symptoms. Diagnostic confusion emerges because many chronic lesions of the nail bed may be clinically similar to SCC. Although SCC of the nail bed is considered a low-grade malignancy, bone invasion and metastasis to the regional lymph nodes may occur. Herein, we reported a case of subungual toenail SCC with bone involvement and a 6-year delay between its appearance and diagnosis.
Onychopapilloma – a rare tumour of the nail apparatus
Introduction. Onychopapilloma is a very rare benign tumour of the nail matrix and nail bed. Clinically onychopapilloma presents as longitudinal erytronychia, exceptionally as leukonychia or melanonychia. After nail avulsion, circumscribed, keratinized cone-shaped structure is seen. In histopathology distal subungual hyperkeratosis and nail matrix metaplasia and papillomatosis are observed. Etiopathogenesis of onychopapilloma is unknown. Treatment is only surgically. Objective. Presentation of first Polish case of onychopapilloma. Case report. A 32 year-old healthy woman was admitted to our department due to subungual longitudianal tumour of the right thumb, presented as erytronychia. Lesion was excised. Histopathologic examination confirmed diagnosis of onychopapilloma. Conclusions. Onychopapilloma is a rare nail apparatus condition with uncharacteristic clinical feature. Tumour should be distinguish from inflam-matory and neoplastic disorders.