Squamous cell carcinoma of the lateral nail fold (original) (raw)
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Squamous cell carcinoma of the nail bed: a case report
International Surgery Journal, 2015
Squamous cell carcinoma of the nail bed is rare and commonly diagnosed late. Presentation is not specific and diagnosis rests on biopsy of the lesion. This condition can be easily misdiagnosed, especially if there is preceding trauma. We are also reporting such case involving the thumb. A 70 years old male patient presented at OPD with complaints of pain and ulcer over left thumb since last 4 months. Patients had lost his thumb nail 6 month back and since then was treated on Ayurvedic treatment. Patient does not give a history of trauma. Biopsy of the ulcer revealed Squamous Cell Carcinoma. His X-ray did not reveal any infiltration and hence a distal phalanx amputation of thumb was performed. Patient had an uneventful post-operative course and on 9 months follow up showed no recurrence. Rare still subungual squamous cell carcinoma should be considered early in lesions around the nail that fail to resolve after adequate conservative management. Early detection helps change surgical treatment from amputation to more preserving techniques like Moh's or wide local flap reconstruction.
Cureus, 2021
The nail apparatus is a complex area with great functional and cosmetic importance. The appearance of tumors is rare, frequently misdiagnosed with delaying the diagnosis. A series of cases is presented, where squamous cell carcinoma of nail apparatus underwent resection and reconstructive surgery in a relatively short time from their diagnosis, with a good oncological, functional, and cosmetic result.
Squamous cell carcinoma of the nail bed: a clinicopathological study of 12 cases
British Journal of Dermatology, 1990
Twelve cases were reviewed of squamous cell carcinoma of the nail bed, with emphasis on the aetiological role of human papiUomavirus (HPV) infection and radiation damage. Using a hybridization technique, similar HPV genomes were detected in a uterine cervical neoplasia and a subungual squamous cell carcinoma in the same patient.
Important malignant and new nail tumors
The nail apparatus is an integral part of the functional unit of the digital tip. Although overall uncommon, all cells and tissues occurring in this area can give rise to neo-plastic lesions. Given the special anatomical location, such tumors frequently show morphological and symptom-related differences compared to similar lesions located elsewhere on the skin. Though particularly threatening, there is often a substantial delay in the diagnosis of Bowen's disease, ungual squamous cell carcinoma, and melanoma. Nevertheless, local excision with sufficient surgical margins is usually sufficient and superior to amputation of the distal phalanx. In recent years, a number of nail-specific tumors have been described. Tumors such as onychomatricoma, ony-chocytic matricoma, onychocytic carcinoma, and onychopapilloma originate from the nail matrix. Onycholemmal cysts, onycholemmal horn, and the proliferating onycholemmal tumor are characteristic nail bed tumors. Onycholemmal carcinoma is a slowly growing low-grade malignancy. Using modern diagnostic methods, careful examination – including biopsy and histopathology – of nail changes not responding to conservative treatment will help identify nail-specific neoplasms and prevent the progression of malignant nail tumors.
Squamous cell carcinoma of the nail apparatus in the population of Northern Poland
Postepy Dermatologii I Alergologii
Introduction: Malignant tumours of the nail apparatus in Caucasian population are rare. Among them melanoma and squamous cell carcinoma (SCC) are the most common diagnoses. Non-characteristic clinical feature of nail appa-ratus SCC (NSCC) may mimic various inflammatory and infectious diseases. Tumour is often misdiagnosed what causes delay of the treatment. Aim: Investigation on frequency, clinical and histopathological characteristics of NSCC in a Northern Poland popu-lation. Material and methods: One thousand five hundred and eighty-eight patients with various nail apparatus patholo-gy who were referred to the Department of Dermatology, Venerology and Allergology, Medical University of Gdansk, from 2005 to 2010, were included in the study. Among all these patients 12 cases of nail apparatus maligancy were diagnosed including 4 cases of NSCC. Results: The NSCC was observed in 0.25% of the patients with nail pathology. Tumour affected only men. Mean age came to 58.3 years old. The m...
Squamous cell carcinoma of the toenail bed: a case report
Global Dermatology, 2016
Subungual Squamous Cell Carcinoma (SCC) is the most common malignancy affecting the nail bed. About 150 cases of subungual SCC have been reported in the literature. It usually involves the thumb, the index finger and only rarely, the toes. Subungual SCC runs an indolent course and may present with minimal symptoms. Diagnostic confusion emerges because many chronic lesions of the nail bed may be clinically similar to SCC. Although SCC of the nail bed is considered a low-grade malignancy, bone invasion and metastasis to the regional lymph nodes may occur. Herein, we reported a case of subungual toenail SCC with bone involvement and a 6-year delay between its appearance and diagnosis.
Mohs Micrographic Surgery of the Nail Unit and Squamous Cell Carcinoma
Dermatologic Surgery, 2001
The nail unit can be a challenging anatomic location for surgical removal of neoplasms. Although uncommon, malignancies do affect this specialized epithelial structure. In particular, Bowen's disease and more invasive squamous cell carcinoma (SCC) are the most common neoplasm's to affect the nail unit and surrounding structures. Other neoplasm's such as basal cell carcinoma and malignant melanoma can also affect the nail unit, but less frequently, and will not be discussed in the scope of this review. Mohs micrographic surgery continues to be the treatment of choice because of the procedure's tissue-sparing qualities. A clear understanding of the anatomy and the histology of the nail unit, a review of the technique of Moh's surgery of the nail anatomy, as well as a review of the literature are presented.
Skin Appendage Disorders
Introduction: Onycholemmal carcinoma (OC) is a rare subtype of squamous cell carcinoma (SCC) that originates from the epithelium of the nail bed. It is characterized by distinct histopathologic features including small clusters of atypical squamous epithelium devoid of a granular layer, with abrupt onycholemmal keratinization. Case Presentation: We present a case of a 75-year-old male with right thumbnail onycholysis, yellow-green nail plate discoloration, as well as bleeding and purulence of the lateral nail fold. Histopathologic evaluation revealed high-grade squamous dysplasia, small clusters of severely atypical epithelial cells, and a pattern of abrupt keratinization consistent with the diagnosis of SCC carcinoma with onycholemmal features. GMS and PAS staining indicated concomitant onychomycosis. Pathologic analysis also disclosed residual SCC and concomitant amyloidosis, possibly light chain related and hence reflective of his underlying multi-organ lymphoplasmacytic lymphoma...
JAMA dermatology, 2017
The best surgical treatment modalities for subungual squamous cell carcinoma (SUSCC) without bone invasion need to be determined. The limited available data on Mohs micrographic surgery do not demonstrate its use as a standard procedure. A previous study in a limited series of patients has shown that wide surgical excision of the nail unit was associated with a low rate of recurrence. To confirm the efficiency of wide surgical excision of the nail unit with full-thickness skin graft reconstruction on a series of patients with SUSCC with an extended follow-up and to evaluate short- and long-term postoperative morbidity and patient satisfaction. A consecutive series of 55 patients with biopsy-proven SUSCC without bone invasion treated by wide surgical excision of the nail unit followed by full-thickness skin graft reconstruction from January 1, 2000, to August 31, 2012 were included. After a minimum follow-up of 5 years, the recurrences were collected from the referring physicians. St...
Synchronous squamous cell carcinoma in multiple digits
Eplasty, 2011
Cancers of the perionychium are relatively rare occurrences and are often related to chronic inflammation associated with trauma, infection, exposure to ultraviolet radiation, or other carcinogens. Squamous cell carcinoma is the most common tumor reported of the nail bed. Synchronous squamous cell carcinomas of the perionychium have been rarely reported. We present a case of a 46-year-old woman with synchronous squamous cell carcinomas involving both hands and multiple digits. Treatment modalities include chemotherapeutics, Mohs surgery, and amputation. Early diagnosis of squamous cell carcinoma of the nail bed provides the greatest chance to preserve maximal function of the hand. Onychomycosis may be the presenting symptom of a patient with squamous cell carcinoma and may also be a predisposing factor in patients with occupational risk factors. Suspicion of this disease process can help the clinician establish the diagnosis via biopsy and provide optimal care for these patients.