Antibodies to the Vitronectin Receptor (Integrin a V b 3 ) Inhibit Binding and Infection of Foot-and-Mouth Disease Virus to Cultured Cells (original) (raw)
The amino acid sequence Arg-Gly-Asp (RGD) is highly conserved on the VP1 proteins of different serotypes and subtypes of foot-and-mouth disease virus (FMDV) and is essential for cell attachment. This sequence is also found in certain extracellular matrix proteins that bind to a family of cell surface receptors called integrins.WithinthePicornaviridaefamily,humanenteroviruscoxsackievirusA9alsohasanRGDmotifonits VP1 capsid protein and has recently been shown to utilize
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