Sphingosine 1-Phosphate Receptors and Metabolic Enzymes as Druggable Targets for Brain Diseases
Paola Giussani
Frontiers in Pharmacology
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Sphingosine 1-Phosphate Receptor Modulators and Drug Discovery
F. Dahlke
Biomolecules & therapeutics, 2017
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Sphingosine 1-phosphate – A double edged sword in the brain
Gerhild van Echten-Deckert
Biochimica Et Biophysica Acta - Biomembranes, 2017
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The role of sphingosine 1-phosphate metabolism in brain health and disease
Gerhild van Echten-Deckert
Review, 2023
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Sphingosine 1-phosphate receptor modulator fingolimod (FTY720) does not promote remyelination in vivo
Giuseppe Faggian
Molecular and Cellular Neuroscience, 2011
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Sphingosine kinase 1/sphingosine-1-phosphate receptors dependent signalling in neurodegenerative diseases. The promising target for neuroprotection in Parkinson’s disease
Joanna B Strosznajder
Pharmacological Reports, 2018
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Sphingosine-1-Phosphate (S1P) and S1P Signaling Pathway Modulators, from Current Insights to Future Perspectives
René Robles-Cedeño
Cells
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Sphingosine-1-Phosphate Receptors: Zooming in on Ligand-Induced Intracellular Trafficking and Its Functional Implications
Dennis Verzijl
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Sphingosine-1-phosphate receptors mediate neuromodulatory functions in the CNS
Leslie Satin
Journal of Neurochemistry, 2009
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Sphingosine 1-phosphate Receptor Modulator Therapy for Multiple Sclerosis: Differential Downstream Receptor Signalling and Clinical Profile Effects
Samuel F Hunter
Drugs
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Emerging biology of sphingosine-1-phosphate: its role in pathogenesis and therapy
timothy hla
The Journal of clinical investigation, 2015
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Implication of sphingosine-1-phosphate signaling in diseases: molecular mechanism and therapeutic strategies
rahat ali
Journal of Receptors and Signal Transduction, 2017
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An update on sphingosine-1-phosphate receptor 1 modulators
Robin Polt
Bioorganic & Medicinal Chemistry Letters, 2018
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Sphingosine 1-Phosphate Receptor 1 Signaling in Mammalian Cells
Nigel Pyne
Molecules, 2017
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Sphingosine-1-Phosphate: Boon and Bane for the Brain
Gerhild van Echten-Deckert
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FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation
yun yung
Proceedings of the National Academy of Sciences, 2011
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Sphingosine 1-Phosphate Receptor 1 (S1P1) Upregulation and Amelioration of Experimental Autoimmune Encephalomyelitis by an S1P1 Antagonist
Pedro Gonzalez-Cabrera
Molecular Pharmacology, 2012
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Sphingosin-1-phosphate Receptor 1: a Potential Target to Inhibit Neuroinflammation and Restore the Sphingosin-1-phosphate Metabolism
Leila Dargahi
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 2015
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Immunohistochemical detection of sphingosine-1-phosphate receptor 1 in vascular and lymphatic endothelial cells
Rosanna Pescini Gobert
Journal of Molecular Histology, 2008
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Benefit–Risk Profile of Sphingosine-1-Phosphate Receptor Modulators in Relapsing and Secondary Progressive Multiple Sclerosis
Ian Williams
Drugs, 2017
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Regulation and functions of sphingosine kinases in the brain
Laurens Bryan
Biochimica Et Biophysica Acta-molecular and Cell Biology of Lipids, 2008
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Sphingosine 1-phosphate pathway therapeutics: a lipid ligand–receptor paradigm
jiayu liao
Current Opinion in Chemical Biology, 2003
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Immunohistochemical Detection of Sphingosine-1-Phosphate and Sphingosine Kinase-1 in Human Tissue Samples and Cell Lines
Roger Sabbadini
Methods in molecular biology, 2017
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Identification of Sphingosine 1-Phosphate Receptor Subtype 1 (S1P1) as a Pathogenic Factor in Transient Focal Cerebral Ischemia
arjun sapkota
Molecular neurobiology, 2017
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Functional antagonism of sphingosine-1-phosphate receptor 1 prevents cuprizone-induced demyelination
narjes dahmardeh
Glia, 2018
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Loss of the neuroprotective factor Sphingosine 1-phosphate early in Alzheimer's disease pathogenesis
J. Kril
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Cis-4-methylsphingosine is a sphingosine-1-phosphate receptor modulator
Dagmar zu Heringdorf, Bianca Hegen, Sandra Labocha, Gerhild van Echten-Deckert
Biochemical Pharmacology, 2011
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Modulators of the Sphingosine 1-phosphate receptor 1
miguel angel davila guerrero
Bioorganic & Medicinal Chemistry Letters, 2013
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Activation of sphingosine 1-phosphate receptor-1 by SEW2871 improves cognitive function in Alzheimer's disease model rats
Abolhassan Ahmadiani
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Sphingosine-1-Phosphate Receptors Modulators Decrease Signs of Neuroinflammation and Prevent Parkinson’s Disease Symptoms in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Mouse Model
Tim Jalinier
Frontiers in Pharmacology
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Sphingolipid Metabolism: A New Therapeutic Opportunity for Brain Degenerative Disorders
Alba Di Pardo
Frontiers in neuroscience, 2018
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Overexpression of sphingosine-1-phosphate receptors on reactive astrocytes drives neuropathology of multiple sclerosis rebound after fingolimod discontinuation
Fabio Bandini
Multiple Sclerosis Journal, 2018
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Selectivity and Specificity of Sphingosine-1-Phosphate Receptor Ligands: Caveats and Critical Thinking in Characterizing Receptor-Mediated Effects
Salvatore Salomone
Frontiers in Pharmacology, 2011
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Discovery of APD334: Design of a Clinical Stage Functional Antagonist of the Sphingosine-1-phosphate-1 Receptor
Jaimie Rueter
ACS medicinal chemistry letters, 2014
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