Drug Transporters on Arachnoid Barrier Cells Contribute to the Blood-Cerebrospinal Fluid Barrier (original) (raw)

Drug Transporters at the Blood–Brain Barrier

David Dickens

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Comparison of a Rat Primary Cell-Based Blood-Brain Barrier Model With Epithelial and Brain Endothelial Cell Lines: Gene Expression and Drug Transport

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Selective drug transport and P-glycoprotein activity in an in vitro blood-brain barrier model

C. Chesne

Toxicology in Vitro, 1995

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Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier

Jan Wijnholds

Journal of Clinical Investigation, 2000

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Membrane transporter proteins: a challenge for CNS drug development

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Dialogues in Clinical Neuroscience, 2006

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Dexamethasone increases expression and activity of multidrug resistance transporters at the rat blood-brain barrier

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Expression of Tight Junction and Drug Efflux Transporter Proteins in an in vitro Model of Human Blood–Brain Barrier

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Evaluation of the immortalised mouse brain capillary endothelial cell line, b.End3, as an in vitro blood–brain barrier model for drug uptake and transport studies

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Brain Research, 2003

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Drug transport across the blood–brain barrier

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Journal of Cerebral Blood Flow & Metabolism, 2012

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Drug transport to the brain: in vitro versus in vivo approaches

Elizabeth CM de Lange

Journal of Controlled Release, 1994

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Subcellular localization of transporters along the rat blood–brain barrier and blood–cerebral-spinal fluid barrier by in vivo biotinylation

Kent Grindstaff

Neuroscience, 2008

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Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites

Carlos Cordon-cardo

Proceedings of the National Academy of Sciences, 1989

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The role of the efflux transporter P-glycoprotein in brain penetration of prednisolone

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Journal of Endocrinology, 2002

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Expression, Up-Regulation, and Transport Activity of the Multidrug-Resistance Protein Abcg2 at the Mouse Blood-Brain Barrier

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Cancer Research, 2004

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ABC transporters, cytochromes P450 and their main transcription factors: expression at the human blood-brain barrier

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Journal of Neurochemistry, 2008

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Double-Transduced MDCKII Cells To Study Human P-Glycoprotein (ABCB1) and Breast Cancer Resistance Protein (ABCG2) Interplay in Drug Transport across the Blood−Brain Barrier

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Molecular Pharmaceutics, 2011

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Multidrug Resistance-Related Transport Proteins in Isolated Human Brain Microvessels and in Cells Cultured from These Isolates

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Journal of Neurochemistry, 2002

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Transport Rankings of Non-Steroidal Antiinflammatory Drugs across Blood-Brain Barrier In Vitro Models

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The human brain endothelial cell line hCMEC/D3 as a human blood-brain barrier model for drug transport studies

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Expression and transcriptional regulation of ABC transporters and cytochromes P450 in hCMEC/D3 human cerebral microvascular endothelial cells

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Biochemical Pharmacology, 2009

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Effect of P-Glycoprotein-Mediated Efflux on Cerebrospinal Fluid/Plasma Concentration Ratio

Yoshihiro Shibata, Akio Kanatani

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Regulation of major efflux transporters under inflammatory conditions at the blood-brain barrierin vitro

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In Situ Transport of Vinblastine and Selected P-glycoprotein Substrates: Implications for Drug-Drug Interactions at the Mouse Blood-Brain Barrier

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Pharmaceutical Research, 2000

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Functional Expression of P-glycoprotein and Organic Anion Transporting Polypeptides at the Blood-Brain Barrier: Understanding Transport Mechanisms for Improved CNS Drug Delivery?

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The AAPS journal, 2017

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Role of multidrug transporters in neurotherapeutics

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Annals of Indian Academy of Neurology, 2009

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Morphine and the blood-brain barrier: diffusion, uptake, or efflux?

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Canadian Journal of Anesthesia/Journal canadien d'anesthésie, 2017

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Saturable Active Efflux by P-Glycoprotein and Breast Cancer Resistance Protein at the Blood-Brain Barrier Leads to Nonlinear Distribution of Elacridar to the Central Nervous System

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Profiling solute carrier transporters in the human blood-brain barrier

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Potential role of ABC transporters as a detoxification system at the blood?CSF barrier

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Advanced Drug Delivery Reviews, 2004

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Regulation of major efflux transporters under inflammatory conditions at the blood-brain barrier in vitro

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Effect of Tacrolimus on Activity and Expression of P-Glycoprotein and ATP-Binding Cassette Transporter A5 (ABCA5) Proteins in Hematoencephalic Barrier Cells

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Biological & Pharmaceutical Bulletin, 2008

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Challenges and strategies for drug transport across the Blood Brain Barrier.

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In Vitro–In Vivo Extrapolation of Key Transporter Activity at the Blood–Brain Barrier

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Drug Metabolism and Disposition, 2019

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Relevance of breast cancer resistance protein to brain distribution and central acting drugs: a pharmacokinetic perspective

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Current drug metabolism, 2018

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