ANTI-INFLAMMATORY POTENTIAL OF CAPPARIS DIVERSIFOLIA WIGHT & ARN.LEAF EXTRACT AGAINST CARRAGEENAN INDUCED PAW EDEMA IN RATS (original) (raw)
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Capparis grandiflora was used to treat diarrhoea and other infective disorders in folklore. The present study aims at evaluating the action of chloroform soluble fraction, ethanol soluble fraction and ether soluble fraction of the leaves of Capparis grandiflora against inflammatory diseases. The anti-inflammatory effects were investigated by employing acute inflammatory model i.e.; carrageenan-induced hind paw oedema and formaldehyde-induced hind paw oedema in rats. The ethanol soluble fraction was found to be the most potent among them which shows good antiinflammatory response with reference to the standard drug indomethacin.
The study was intended to evaluate the anti-inflammatory activity of ethanolic extract of leaves of Capparis sepiaria (Capparidaceae) (EECS) in Wistar rats. Phytochemical analysis was carried out by using standard methodology. The plant has alkaloids, amino acids, glycosides, reducing sugars, saponins, starch, steroids, tannins and terpenoids. The anti-inflammatory activity was carried out in different methods such as carrageenan, cotton pellet and croton oil induced oedema. Different doses (100, 200 and 300 mg/kg/i.p.) of EECS were injected to rats and the results were compared with standard drug indomethacin (10mg/kg). Paw volume was measured using digital plethysmometer. The C. sepiaria extract showed the maximum inhibitory activity at 300 mg/kg/i.p. in a dose dependent manner. These inhibitions were statistically significant (p<0.01-0.001). These results indicate that C. sepiaria extract is a bioactive agent and having significant results in anti-inflammatory action by inhibition of the exudation, and leukocytes recruitment into the inflamed tissues.
Electronic Journal of Pharmacology and Therapy, 2009
The study was intended to evaluate the anti-inflammatory activity of ethanolic extract of leaves of Capparis sepiaria (Capparidaceae) (EECS) in Wistar rats. Phytochemical analysis was carried out by using standard methodology. The plant has alkaloids, amino acids, glycosides, reducing sugars, saponins, starch, steroids, tannins and terpenoids. The anti-inflammatory activity was carried out in different methods such as carrageenan, cotton pellet and croton oil induced oedema. Different doses (100, 200 and 300 mg/kg/i.p.) of EECS were injected to rats and the results were compared with standard drug indomethacin (10 mg/kg). Paw volume was measured using digital plethysmometer. The C. sepiaria extract showed the maximum inhibitory activity at 300 mg/kg/i.p. in a dose dependent manner. These inhibitions were statistically significant (p<0.01-0.001). These results indicate that C. sepiaria extract is a bioactive agent and having significant results in anti-inflammatory action by inhibition of the exudation, and leukocytes recruitment into the inflamed tissues.
Anti-inflammatory and Immuno-modulatory Effects of Capparis spinosa Flower Bud Extract
Annual research & review in biology, 2018
Aims: Capparis spinosa L. is a plant widely used in traditional medicine for its different purpose including the anti-inflammatory properties. The aim of this study was to evaluate the antiinflammatory properties of this plant and to define its possible mechanism of action by verifying its effect on the production of some inflammatory mediators. Methodology: The anti-inflammatory activity of Capparis spinosa bud methanolic extract was evaluated in vivo, using paw edema and air pouch inflammation models. In vitro, the ability of the extract to modulate the production of some pro and anti-inflammatory mediators such as TNF-α, IL-1β, IL-8 and IL-10 released from peripheral blood mononuclear cells stimulated by concanavalin A
Pharmacognosy Journal, 2019
Capparis erythrocarpus is a shrub that belongs to the Capparaceae family of flowering plants. The plant is mostly scandent with 3-14 cm long and 1.5-5.0 cm broad leaves of different shapes that ranges from abovate through elliptic to ovate and lanceolate. Furthermore, the leaf has cuneate to rounded base and sharply acuminate to obtuse apex. 1 The plant produces 5.0 cm long scarlet fruits from flowers which sprouts as cluster of stout pedicels at the end of young branches. 1 The stem is full of sharp long thorns. The leaf is also full of clusters of tiny thorns. The root of C. erythrocarpus is used in traditional medicine to treat rheumatoid arthritis, blurred vision, partial male impotence, urinogenital pain, otitis, ear pain and gas in the stomach. 1,2 The powdered root bark of C. erythrocarpus (Known as Serapac) is an oral herbal medication dispense at the Centre for Plant Medicine research at Mampong-Akwapim, Ghana for treatment of arthritis, pain and inflammatory disorders. Chronic toxicity studies, anti-arthritic and anti-nociceptive activities of the root bark of
Journal of Ethnopharmacology, 2012
Ethnopharmacological relevance: Capparis ovata Desf. has wide natural distribution in Turkey and it is consumed in pickled form. Flower buds, root bark, and fruits of the plant are used traditionally due to their analgesic, anti-inflammatory, wound healing, anti-rheumatismal, tonic, and diuretic effects. Aim of the study: The aim of this study was to investigate the possible anti-inflammatory and antithrombotic effects of methanol extracts prepared from flower buds (CBE) and fruits (CFE) of C. ovata. Materials and methods: Anti-inflammatory effects of CBE and CFE were assessed using carrageenaninduced and prostaglandin E 2 -induced mouse paw edema models. For the anti-thrombotic effect evaluation, carrageenan-induced tail thrombosis model was performed in mice. The extracts were administered intraperitonally (i.p.) at the doses of 100, 200, and 300 mg/kg. The anti-inflammatory effect of Capparis extracts were tested in comparison to 10 mg/kg diclofenac and anti-thrombotic activity to 10 and 100 IU heparin. Results: CBE at the doses of 200, and 300 mg/kg and CFE at the doses of 100, 200, and 300 mg/kg showed significant anti-inflammatory activity and CFE reached therapeutic concentration early than CBE in carrageenan inflammation model. In prostaglandin E 2 inflammation model, CBE and CFE exhibited significant inhibitory effects. The C. ovata extracts did not show remarkable anti-thrombotic effect.
Objective: Among the invention of novel anti-inflammatory agents from modern research and drug development, the natural sources exist as evergreen to produce potential secondary metabolites that possess multiple efficacy against inflammatory mediators with no adverse reactions. Methods: Accordingly, Cadaba indica lam (Capparidaceae) produced the positive results for phenol, flavonoids, steroid, and saponins in preliminary phytochemical screening and exhibited the potent anti-inflammatory activity (100 mg/kg, 200 mg/kg) by methanolic leaf extract against carrageenaninduced paw edema using rats in dose-dependent manner stayed closer to reference standard indomethacin (25 mg/kg) compared to petroleum ether and aqueous extract. Results: Thus, the plant C. indica lam might be considered to posses potential secondary metabolites against inflammatory agents and act as lead to isolation of novel therapeutic compounds. Conclusion: The phytochemical test indicates the presence of phenol, flavonoids, steroid, and saponins in leaf extract of C. indica may be known to possess anti-inflammatory property. The result of anti-inflammatory activity produced by the methanolic extract was threshold of isolation of bio molecules from the natural sources in diverse drug development in the near future being responsible for the pharmaceutical industries.
2017
The current study is formulated to discover the mechanism of action and formulation of Capparis moonii against experimentally induced inflammation /paw oedema and pyrexia in rats. The effect of Ethanolicextract of Capparis moonii(fruit) was investigated in rats to evaluate the anti-inflammatory activity by using two models, i.e. Paw volume method by using Plethysmograph, the Vernier Calliper methodand anti-pyretic activity by the model of Yeast induced pyrexia method. The parameters taken to assessanti-inflammatory activity wereoedema, difference in paw volume of rat, amount of inflammation produced, percent oedema inhibition and yeast volume injected, difference in the rectal temperature, pyrexia. Indomethacin (25mg/kg) was used as positive control for both the activities. The results indicate that the Ethanolicextract of Capparis moonii (EECM) significantly (P <0.05) decreases the oedema, difference in paw volume of rat, amount of inflammation produced, percent oedema inhibitio...
International Journal of Pharmacy and Pharmaceutical Sciences
Objective: To investigate phytochemicals and biological activities of Capparis cartilaginea extracts.Methods: The methanolic extracts of leaves, stem and twigs of C. cartilaginea were screened for their phytochemicals. The essential oil of the leaves was hydrodistilled by a Clevenger apparatus and analyzed by gas chromatography-mass spectrometry (GC-MS). The leaves extract of C. cartilaginea was evaluated for its anti-inflammatory effect, using formalin-induced paw edema. The leaves, stem and twig extracts were assessed for their antioxidant activity, using free radical scavenging assay, cytotoxic activity, using 3-[4,5-dimethylthiazole-2-yl]-2,5-diphenyltetrazolium bromide (MTT) assay and antibacterial activity, using the microdilution method.Results: All extracts of C. cartilaginea contained alkaloids, carbohydrates, protein, coumarin, phytosterols, bitter principles, phenols and tannins. The essential oil of the leaves was mainly composed of isopropyl isothiocyanate (69.4%), buta...
Immunology and Infectious Diseases
Capparis decidua has been traditionally used in the Ayurveda to treat rheumatoid arthritis and it is reported to have anti-inflammatory and analgesic activity. Considering its anti-inflammatory activity the present research work has been designed to assess the anti-arthritic activity in Wistar rats. The anti-arthritic activity of hydroalcoholic extract of C. decidua root, stem and leaves was evaluated using Freund's complete adjuvants (FCA) induced arthritic models in Wistar rats. Oral administration of C. decidua extract at the dose of 100mg/kg, 200mg/kg, per se group (only 200mg/kg of C. decidua) was subjected to Wistar rats for 28 days. Standard drug Diclofenac sodium at the dose of 5mg/kg and FCA at 1mg/ml was used in the study. The normal control group was administered only distilled water at 1ml/kg without induction of arthritis. The arthritic investigation was carried out on basis of parameters including changes in body weight, paw volume, hematological studies like ESR count, RBC count, WBC count, Hemoglobin count, platelet count. At the end of study period, animals were sacrificed and histological parameters were evaluated. Phytochemical analysis of C. decidua extract was done to assess the various constituents present in C. decidua. The results of C. decidua extract administration significantly (P<0.001) attenuated the body weight, paw volume, hematological alteration induced by the FCA in dose-dependent manner. The tarsal joint was extracted for histopathological studies. The overall results indicate that C. decidua extract (100mg/kg and 200mg/kg) showed a potent protective effect against FCA induced arthritic rats which could be attributed to phytoconstituents present in C. decidua and its effect is comparable to the standard drug diclofenac sodium.