PRELIMINARY IN VIVO EVALUATION OF ANTI-INFLAMMATORY ACTIVITIES OF VARIOUS SOLVENT EXTRACTS OF CADABA INDICA LAM ON CARRAGEENAN-INDUCED PAW EDEMA IN SWISS ALBINO RATS (original) (raw)
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The present study was carried out to evaluate the anti-inflammatory potential of ethanol leaf extract of Capparis diversifolia using carrageenan induced paw edema method in rats. The anti-inflammatory activity of ethanol leaf extract in 200mg/kg b.wt and 400mg/kg b.wt at 3hours of administration was compared with reference standard drug, Indomethacin 100mg/kg b.wt. Maximum anti-inflammatory effect was exhibited in 400mg/kg b.wt. The present study confirms the traditional usage of C. diversifolia for anti-inflammatory activity and supports the isolation and use of phytoconstituents with anti-inflammatory activity from C. diversifolia.
Journal of Traditional and Complementary Medicine, 2015
The present study was carried out to evaluate in vivo and in vitro anti-inflammatory potential of selected medicinal plants used in Indian traditional medication. The sequentially extracted plant samples as, Cissus quadrangularis, Plumbago zeylanica, Terminalia bellarica and Terminalia chebula in water, ethanol and hexane were evaluated in-vitro for COX-1 and 2 inhibitory and antioxidant activities. The in vivo antiinflammatory activity of selected samples showing promising COX-2 inhibition was assessed using carrageenan and Phorbol Myristate Acetate (PMA) induced mice edema animal model. The results obtained reveals that most of the plants were found to inhibit COX-2 activity as compared to COX-1. It was observed that the extracts of T. bellarica (73.34 %) and T. chebula (74.81 %) showed significant COX-2 selective inhibition as compared to other samples. The ethanol extract of the selected plants demonstrated effective DPPH, OH and superoxide radical scavenging activity. In vivo anti-inflammatory study shows that, T. bellarica and T. chebulla had a significant impact on inhibition of edema formation. The cytotoxicity evaluation study of ethanolic fraction of selected medicinal plants indicates that the selected samples have no effect on cell viability. HPTLC fingerprint of flavonoids of the selected samples was also prepared as a measure of quality control. The results obtained may be useful in strengthening the standardization of the selected botanicals. Moreover the selected plants can be considered as a resource for searching novel anti-inflammatory agents possessing COX-2 inhibition.
Anti-Inflammatory effect of ethyl acetate extracts and pure molecules of ethno medicinal plants
Journal of Pharmacognosy and Phytochemistry, 2016
Aim/Objective: To evaluate the anti-inflammatory activity of ethyl acetate extracts and pure molecules of roots of M. malabaricum, A. serpyllifolia, and L. aspera Materials and Methods: Edema was induced by injecting subcutaneously into the sub plantar tissue of the left hind paw of each Wistar rat (150 to 200 g [N=30]), 0.1 mL of 1% carrageenan suspension in saline. Rats were treated with drug vehicle (1% Sodium CMC) and served as normal control and those treated with ibuprofen as standard. Ethyl acetate extracts of M. malabaricum, A. serpyllifolia, L. aspera and pure molecules MM-1, AS-1, LA-1 obtained from ethyl acetate extract were tested for carrageenan induced paw edema. The drug effects were estimated by comparing the maximal edema response during 6 h and the total edema response as the area under the time course curve. Results: Results showed that the ibuprofen (62.23 ±1.88), crude extract of M. malabaricum (48.55 ± 1.27, 56.52 ± 0.38 and 59.92 ± 0.78), A. serpyllifolia (40....
Evaluation of anti-inflammatory activity of some Libyan medicinal plants in experimental animals
Archives of Biological Sciences, 2012
Ballota pseudodictamnus (L.) Benth. (Lamiaceae), Salvia fruticosa Mill. (Lamiaceae) and Thapsia garganica L. (Apiaceae) are three well-known medicinal plants from the Libyan flora, which have long been used for the treatment of inflammations. The aim of the present study was to investigate, for the first time, the anti-inflammatory property of the methanol (MeOH) extracts of the aerial parts of these plants. Shade-dried and ground aerial parts of B. pseudodictamnus, S. fruticosa) and T. garganica were Soxhlet-extracted with MeOH. The extracts were concentrated by evaporation under reduced pressure at 40?C. The anti-inflammatory activity of the extracts was evaluated using the carrageenan-induced mice paw edema model. The administration of the extracts at a dose of 500 mg/kg body weight produced statistically significant inhibition (p < 0.05) of edema within 3 h of carrageenan administration. The results demonstrated significant anti-inflammatory properties of the test extracts. A...
Comparative Evaluation of Anti-Inflammatory Potential of Medicinally Important Plants
2013
Objective: Selected medicinal plants are either singly or in combination have been used traditionally for the management of variety of conditions especially against inflammatory disorders. They include Aegle marmelos (L.) Corr., Desmodium gangeticum (L.) DC., Gmelina arborea Roxb., Oroxylum indicum Vent., Premna optusifolia R. Br., Solanum anguivi Lam., Solanum virginianum L., Stereospermum colais Mabb. Tribulus terrestris L. and Uraria picta (Jacq.) Desv. ex DC. They are the constitutents of Ayurvedic Dashamoola which is a combination of roots of ten plants, owing to a unique combination of ten plants that play specific role in treatment of different conditions. Few of them are known to possess anti-inflammatory activity individualy but comparative study of these plants has never been carried out, therefore we have comparatively investigated these plants for their anti-inflammatory activity. Method: Water decoctions of roots were administered orally using in vivo Carrageenan induce...
Pakistan journal of pharmaceutical sciences, 2015
Investigations for anti-inflammatory potential and categorization of Sudanese medicinal plants according to their potency. Anti-inflammatory effect of plants' extracts of 17 genera were studied using the carrageenan induced inflammation in rats' paws. The plant extracts were obtained using methanol and dichloromethane as solvent and administered intra peritoneally at the concentration of 2g/kg body weight. The results obtained in this experiment strongly support and validate the traditional uses of these Sudanese medicinal plants to treat various inflammatory diseases. 63.9% of plants extracts showed marked inhibition of inflammation induced by carrageenan (78.3% out of this percentage represented by methanolic extract), 27.8% showed no activity and 8.3% enhanced the carrageenan induced inflammation. The anti-inflammatory effect of many of these plants has not been reported previously, yet they have been extensively used in Sudanese folkloric medicine. The result of this stu...
Jundishapur Journal of Natural Pharmaceutical Products, 2015
Background: Medicinal plants are believed to be important sources of new chemical substances with potential therapeutic effects. Washingtonia filifera is characterized by its high content of flavonoids. Numerous studies suggest that flavonoids have potential for the prevention and treatment of several diseases. Objectives: This study aimed to investigate the anti-inflammatory activity of the Washingtonia filifera seeds' hydroalcoholic extract (WSE). Materials and Methods: The hydroalcoholic extract was administered to male Wistar rats. Carrageenan-induced paw edema was used to evaluate the anti-inflammatory activity. The WSE (100, 200, and 400 mg/kg) or vehicle were administered intraperitoneally 30 minutes before the subplantar injection of carrageenan. Intraperitoneal indomethacin (10 mg/kg) was used as standard drug. Results: The intraperitoneal WSE (100-400 mg/kg) produced the anti-inflammatory effect in a dose-dependent manner with a median effective dose (ED50) of 164.4 mg/kg (124.16-203.7 mg/kg). Furthermore, the anti-inflammatory effect of WSE was comparable to indomethacin (10 mg/kg) Conclusions: These results indicated that WSE has a potent anti-inflammatory action and confirmed that the extract contains an effective anti-inflammatory substance(s).
Anti-inflammatory potential of medicinal plants
CERN European Organization for Nuclear Research - Zenodo, 2022
Inflammation is said to be a healthy component of the body immune system's reaction. Inflammation is characterised by four key symptoms: pain, redness, heat or warmth and swelling. As secondary metabolites, plants may produce a wide range of phytochemical compounds, which possess antiinflammatory characteristics. Herbal remedies are important therapies for a wide range of ailments all over the world. There are around 7 500 species of medicinal plants, including representatives from over 17 000 flowering plant species. Even when synthetic chemistry has developed out their expectations, the use of natural ingredients in the manufacture of drugs used in contemporary medicine is unparalleled. By interfering with the biology of inflammation, anti-inflammatory medications may assist to minimise tissue damaging and increase patient's comfort. Because of the bulky figure of species reachable for study, the effective development of novel naturally taking place anti-inflammatory drugs is mostly dependent on a multidisciplinary approach to discovering new chemicals. Despite the statistic that many review papers have been produced in this field, the conventional of them simply examined the issue from an area perspective. Several non-steroidal anti-inflammatory drugs have been shown to reduce inflammation and pain by decreasing the isoform of the cyclooxygenase enzyme's digestion of arachidonic acid, hence lowering prostaglandin production. Non-steroidal anti-inflammatory drugs have a host of harmful effects. There are, however, medicinal herbs with anti-inflammatory pharmacological properties that have few or no negative effects.
Activity of some Mexican medicinal plant extracts on carrageenan-induced rat paw edema
Phytomedicine, 2004
The extracts obtained from 14 plants of the Mexican medicinal flora were assessed for anti-inflammatory activity by carrageenan-induced rat paw edema model. The i.p. administration of the extracts at a dose of 400 mg/kg produced a high reduction of edema with 70% of the plant extracts. Oenothera rosea methanol extract, Sphaeralcea angustifolia chloroform extract, Acacia farnesiana, Larrea tridentata and Rubus coriifolius methanol extracts as well as the aqueous extract of Chamaedora tepejilote were demonstrated to be particularly active against the induced hind-paw edema. Moderate inhibition of edema formation was also demonstrated with the methanol extracts of Astianthus viminalis, Brickellia paniculata, C. tepejilote and Justicia spicigera.