Facile and Rapid Synthesis of Polysubstituted Imidazoles by Employing Y(NO3)3×6H2O as Catalyst (original) (raw)
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ChemInform, 2012
An efficient and environmentally adapted synthesis of polysubstituted imidazoles in one-pot and multicomponent reaction of various aldehydes, benzil, aliphatic and aromatic primary amines and ammonium acetate under solvent-free condition is reported. Highly efficient role of Y(NO 3 ) 3 × 6H 2 O as catalyst in this synthesis was shown. By this advantage, several polysubstituted imidazoles as pharmaceutical important molecules can be prepared in high yield and high purity. This method is very easy and rapid for the synthesis of imidazole derivatives. All products were deduced from their IR and NMR spectroscopic and elemental analysis data. The catalyst exhibited remarkable reusable activity. (doi: 10.5562/cca1979)
Synthesis and Characterization of Imidazole Derivatives and Catalysis Using Chemical Pharmaceutical Compounds, 2019
This review is an updated and expanded version of imidazole represent an important class of heterocycles, which contains two hetero (nitrogen) atoms and two double bonds. There are so many compounds which contain Imidazole ring and exhibit different types of pharmacological and biological activities such as antimicrobial, antitumor, antiepileptic, and antihistaminic, anti oxidative, anti-inflammatory, anti diarrhoeal, analgesic, which has caused an excessive use of drugs.
An Efficient Synthesis of 2,4,5-Trisubstituted and 1,2,4,5-Tetrasubstituted-1H-imidazoles
ChemInform, 2006
A simple, and environmentally benign synthesis of 2,4,5trisubstituted and 1,2,4,5-tetrasubstituted imidazoles has been successfully accomplished via multi-component cyclo-condensation of 1,2-dicarbonyl, aldehyde, and ammonium acetate and aniline respectively, using dihydroquinoline based novel orga-nocatalysts at refluxed temperature in ethanol. High yields (94 %), easy work-up and purification of products without column chromatography are the key advantages of the method.
A simple, highly efficient and environmentally friendly method has been developed for the synthesis of 2-(1,3-diphenyl-1H-pyrazol-4-yl)-1H-benzo[d]imidazole by using Gadolinium(III) trifluoromethanesulfonate catalyst and ethanol reflux reaction conditions By using this method. 12 new 2-(1,3-diphenyl-1H-pyrazol-4-yl)-1H-benzo[d]imidazole derivatives were synthesized under optimized reactions conditions. All these new products structures are confirmed by spectral analysis. By this method, we achieved imidazole derivatives with more operational simplicity, short reaction time and good yields (up to 85%).
Tetrahedron Letters, 2008
InCl 3 Á3H 2 O was found to be a mild and effective catalyst for the efficient, one-pot, three component synthesis of 2,4,5-trisubstituted imidazoles at room temperature. Moreover, the utility of this protocol was further explored conveniently for the one-pot, four component synthesis of 1,2,4,5-tetrasubstituted imidazoles in high yields.
Zeitschrift für Naturforschung B, 2015
Ten 1,2,4,5-tetra-substituted imidazole derivatives have been synthesized with a 2-hydroxyethy substituent at the 1-nitrogen atom and potentially electron releasing hydroxy-, methoxy-, dimethylamino- or nitro substituents in various positions on the benzene ring located on the 2-carbon atom. The prototypical derivative with an unsubstituted phenyl ring at the 2-position is also reported. The compounds are obtained in excellent yields (average 86%) via a four-component cyclocondensation reaction of benzil, ethanolamine, and the appropriate aromatic carbaldehyde together with ammonium acetate. The reaction uses a novel ionic liquid catalyst, DEAHS (diethyl ammonium hydrogen sulfate), under solvent-free conditions and a green synthetic protocol. The key advantages of this process are high yield, shorter reaction times and ease of work-up. Furthermore, the products can be purified by a non-chromatographic method and the catalyst is re-usable. All of these newly synthesized compounds hav...
One pot three-component synthesis of imidazole derivatives using NH3/NH4Cl
2017
Imidazole is a planar, five membered heteroaromatic molecule with pyrrole type and pyridine type annular nitrogens. Several approaches are available of imidazoles from alpha halo ketones, aminonitrile, aldehyde ect. Reactivity of imidazole and benzimidazole is referred from sets of resonance structure in which the dipolar contributors have finite importance. Imidazoles among the principal groups of heterocyclic compounds that have biological properties. Due to the presence of imidazole rings in natural products and active pharmaceutical ingredients, different ways for the synthesis of heterocyclic compounds of this type investigated. The aim of this project is substituted derivatives 2,4,5-Imidazoles. In this study, three-substituted imidazole compounds synthesized using ammonium chloride as a catalyst cost in terms of reflux were studied. Reaction with aldehydes and ammonium acetate Acenaphthene quinone in crowding conditions in the presence of ammonium chloride was performed suc...