INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACEUTICAL SCIENCES Investigation serum uric acid in cardiovascular mortality and all-cause mortality men and women in AL-Muthanna province-Iraq Production and Hosted by (original) (raw)
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Background: Nowadays, cardiac disease is the most widespread reason of death in most countries such as Iran. Some studies have correlated serum uric acid level with risk of death in the patients of acute coronary syndrome. The study aimed to determine if there is any correlation between serum uric level and atherosclerosis burden. Material and methods: In this cross-sectional study, all the patients underwent coronary angiography in Hamadan's Ekbatan Hospital in 2015 and were studied in terms of demographic, serum lipid profile, blood glucose and uric acid. Data were obtained from patients' medical records, registered in data sheet and analyzed by spss16 statistical software. Results: 140 patients participated in this study of whom 60% were male and 40% female with age mean of 62.92 AE 11.21 years old. Blood uric acid's mean was 6.39 AE 2.16 mg/dl and based on coronary artery involvement range was single vessel disease (6.17 AE 1.91), two vessel disease (6.56 AE 2.17), three vessel disease (6.32 AE 2.01), mild or minimal or patent (6.78 AE 3.16) and in ectatic or slow flow (7.30 AE 0.86) mg/dl, respectively. According to the results of Krus-kaleWallis test, no significant relation was observed between uric acid level and the range of
Acta Cardiologica, 2001
, ******* see acknowledgments for the composition of the group. Objective-The Gubbio Study is an Italian population study measuring risk factors for and incidence of major cardiovascular diseases.This analysis investigates the association of serum uric acid with the incidence of coronary and cardiovascular events. Methods-A population sample of 2469 men and women aged 35-74 years, free from major cardiovascular diseases and in whom serum uric acid was measured in 1983 along with other standard risk factors, were followed up for 6 years and the incidence of coronary heart disease (CHD) and all cardiovascular atherosclerotic (CVD) events, both fatal and non-fatal, was computed. Proportional hazards models were used for the prediction of these events. Results-In six years 61 CHD hard criteria, 109 CHD any criterion and 149 CVD events were recorded. Age-adjusted rates per 1000 of the 3 event categories were computed in sex-specific quintiles (Q) of serum uric acid with 428 ± 76 (Q 5) and 198 ± 42 (Q 1) µmol/l, respectively. Although higher rates were seen in Q 5 as compared to Q 1 for all three first event categories considered (relative risks 6.2, 3.6 and 3.7, respectively), a statistically significant trend was seen only for CVD all criteria (t = 3.63, p < 0.036). These trends were borderline significant for CHD any criterion (t = 2.92, p < 0.06) and not significant for CHD hard criteria (t = 2.23, p < 0.11). In multivariate models, adjusted for 8 other risk factors, serum uric acid showed a statistically significant contribution to predict CVD incidence [relative risk (RR) for 92 µmol/l difference of 1.24 with 95% confidence intervals (CI) 1.05-1.45], whereas the statistical contribution to predict CHD any criterion (RR = 1.19 with CI 0.98-1.45) and CHD hard criteria (RR = 1.20 with CI 0.93-1.55) was not significant. Diuretic treatment and blood urea, as further confounders, were positively and significantly related to event incidence (RR ranging from 1.21 to 2.00) but serum uric acid maintained its independent and statistically significant role in the prediction of CVD events (RR = 1.18 with CI 1.00-1.39). Presence of specific treatments to lower serum uric acid levels (in 1.13% of the population), tested as final confounders, was not statistically contributory. Conclusions-Increased serum uric acid levels are independently and significantly associated with risk of CVD events in the 6-year follow-up of the Gubbio Study. Longer follow-up is needed before the contributory role of serum uric acid can be properly assessed to explain CHD incidence.
Significance of serum uric acid levels on the risk of all-cause and cardiovascular mortality
Rheumatology (Oxford, England), 2013
To assess the associations between serum uric acid (SUA) level and mortality. The study included 354 110 subjects without a history of gout and whose SUA levels were tested at Chang Gung Memorial Hospital in Taiwan. Cox regression models were used to estimate hazard ratios and 95% CIs for mortality in six predefined SUA strata (≤0.17, 0.18-0.29, 0.30-0.41, 0.42-0.53, 0.54-0.65 and ≥0.66 mmol/l), after adjusting for age, sex, SUA stratum, estimated glomerular filtration rate, fasting glucose, total cholesterol and history of hypertension, diabetes mellitus, coronary heart disease, stroke, heart failure or chronic kidney disease. There were 33 562 all-cause deaths during the study period. Crude all-cause mortality rates across the SUA strata were 52.5, 19.7, 17.4, 20.0, 28.0 and 41.1 deaths per 1000 person-years. Using the stratum 3 of SUA as a reference, the age- and sex-adjusted hazard ratios (95% CIs) across SUA strata were 2.79 (2.62, 2.96), 1.32 (1.28, 1.36), 1.00, 1.10 (1.07, 1....
Objective: The aim of this study is to find out an association between the levels or concentration of serum uric acid in the patients present with the suspicion of suffering from CAD (Coronary Artery Disease). Methodology: Study group consisted six hundred and eighty-seven patients with suspicion of coronary artery diseases. All these patients underwent coronary angiography. Stenosis of equal or greater than 50.0% luminal diameter defined coronary artery disease. The expression of the severity of the coronary artery disease was performed as 1-vessel, 2-vessel, or 3-vessel disease. We used the standard of NCEP-ATP 3 (National Cholesterol Education Program-Adult Treatment Panel-3) for MS (Metabolic Syndrome). We obtained the aorto-femoral PWV (Pulse-Wave Velocity) invasively by arterial catheterization. Results: Total three hundred and ninety-five patients were present with coronary artery disease. the level of serum uric acid was high in the patients suffering from coronary artery disease as compared to the patients present without coronary artery disease (5.50 ± 1.00 vs. 5.20 ± 1.00 mg/dL, P= 0.0040). Additionally, there was significant association of serum uric acid with the coronary artery disease severity (P= 0.0020). However, after the adjustment for important confusing factors including DM (Diabetes Mellitus), age, cholesterol level, smoking, metabolic syndrome, PWV and serum uric acid, we found that there was not independent risk factor for incidence of coronary artery diseases (P= 0.1510). On the basis of analysis of subgroup , there was close association of serum uric acid with incidence of coronary artery disease in females as compared to males and in highest quartile ≥ 6.40mg/dL than in initial quartile < 4.80mg/dL; but these results were not much significant (P= 0.0620, P= 0.0750, respectively). According to multivariate regression analysis, Metabolic Syndrome was the most vital determinant of serum uric acid, which has strong association with the incidence of coronary artery disease. Conclusions: In suspected patients of coronary artery disease, serum uric acid was not a risk factor for this complication and it may be simply an indicator of resistance to insulin.
2001
Although elevated serum uric acid has been associated with an increased risk of cardiovascular disease, its importance as a risk factor is still controversial. The authors examined the relationship between serum uric acid levels and death from all causes, including cardiovascular disease and stroke. The baseline data were collected in the National Cardiovascular Survey in 1980. The survey was carried out for all household members aged 30 years or older in 300 districts, which were randomly selected throughout Japan. The number who participated in the survey was 10,897. The vital status was ascer-tained in 1994. Finally, 8172 subjects were available for the analyses. There were 108,284 person-years of follow-up, and 960 deaths from all causes, 249 deaths from cardiovascular disease, and 174 deaths from stroke. After adjustment for age and other cardiovascular disease risk factors, uric acid levels were not associated with mortality from all causes, cardiovascular disease, or stroke. These findings indicate that serum uric acid levels are not related to increased risk for death from all causes, including cardiovascular disease and stroke in a Japanese population.
Serum uric acid levels and its association with cardiovascular risk factors
Iranian Journal of …, 2009
Background: Although the issue of hyperuricemia as a risk factor for cardiovascular diseases (CVD) has been disputed, several studies have shown an association between hyperuricemia and several CVD risk factors. The aim of this study was to assess distribution of uric acid level in Yazd City, center of Iran, and its association with CVD risk factors. Methods: From autumn 2004 to summer 2005, 2000 urban population of Yazd City, aging 20-74 years via clustering random sampling were enrolled in this cross sectional study. Results: Serum uric acid level, systolic blood pressure (SBP), diastolic blood pressure (DBP) and waist/hip ratio were significantly higher in men than in women (P< 0.001),moreover, total cholesterol, HDL cholesterol and body mass index (BMI) were significantly higher in women (P< 0.001). The prevalence of hyperuricemia and metabolic syndrome in men and women was (17.9%, 11.25% P= 0.001) and (11.87%, 19.32% P= 0.01), respectively. Hyperuricemia was more prevalent in metabolic syndrome and ischemic heart disease independent of age and sex. Conclusion: Significant correlations were found between serum uric acid and several components of the metabolic syndrome. Weight, waist circumstance, triglyceride level and DBP, were the major determinants of the variations in serum uric acid levels .This could be attributed to the insulin resistance status .
2020
Objective: The aim of this study is to find out an association between the levels or concentration of serum uric acid in the patients present with the suspicion of suffering from CAD (Coronary Artery Disease). Methodology: Study group consisted six hundred and eighty-seven patients with suspicion of coronary artery diseases. All these patients underwent coronary angiography. Stenosis of equal or greater than 50.0% luminal diameter defined coronary artery disease. The expression of the severity of the coronary artery disease was performed as 1-vessel, 2-vessel, or 3-vessel disease. We used the standard of NCEP-ATP 3 (National Cholesterol Education Program-Adult Treatment Panel-3) for MS (Metabolic Syndrome). We obtained the aorto-femoral PWV (Pulse-Wave Velocity) invasively by arterial catheterization. Results: Total three hundred and ninety-five patients were present with coronary artery disease. the level of serum uric acid was high in the patients suffering from coronary artery disease as compared to the patients present without coronary artery disease (5.50 ± 1.00 vs. 5.20 ± 1.00 mg/dL, P= 0.0040). Additionally, there was significant association of serum uric acid with the coronary artery disease severity (P= 0.0020). However, after the adjustment for important confusing factors including DM (Diabetes Mellitus), age, cholesterol level, smoking, metabolic syndrome, PWV and serum uric acid, we found that there was not independent risk factor for incidence of coronary artery diseases (P= 0.1510). On the basis of analysis of subgroup , there was close association of serum uric acid with incidence of coronary artery disease in females as compared to males and in highest quartile ≥ 6.40mg/dL than in initial quartile < 4.80mg/dL; but these results were not much significant (P= 0.0620, P= 0.0750, respectively). According to multivariate regression analysis, Metabolic Syndrome was the most vital determinant of serum uric acid, which has strong association with the incidence of coronary artery disease. Conclusions: In suspected patients of coronary artery disease, serum uric acid was not a risk factor for this complication and it may be simply an indicator of resistance to insulin.
Pitfalls in the evaluation of uric acid as a risk factor for vascular disease
Open Clinical Chemistry Journal, 2010
The association between serum uric acid (SUA) levels and the risk for vascular disease is controversial. Several studies in the general population suggested that elevated SUA levels are independently related to increased vascular morbidity and mortality. However, in other studies this relationship was not significant when other vascular risk factors were considered. Some evidence also suggests that uric acid might be implicated in the development of hypertension, renal disease and insulin resistance. We review the epidemiological data on the relationship between SUA levels and vascular disease and summarize the potential adverse vascular effects of uric acid. We also discuss the associations of SUA levels with established vascular risk factors and the potential benefits of lowering SUA concentration. It is unclear whether uric acid is a causal risk factor for vascular disease. Until more conclusive data are available, patients with elevated SUA levels should be evaluated for the presence of more established risk factors (including type 2 diabetes mellitus, metabolic syndrome and chronic kidney disease) and treatment should be targeted against these factors.
Association between serum uric acid levels and cardiovascular risk factors among adults in India
Nutrition, Metabolism and Cardiovascular Diseases
Background The importance of uric acid has been increasingly appreciated because of its association with the development of diabetes mellitus and related diseases. Objective This study was undertaken to evaluate the association of serum uric acid (SUA) level with different clinical and biochemical parameters in patients with type 2 diabetes from Saudi Arabia. Methods Clinical and biochemical data from the patients were obtained and assessed in a cross-sectional design. Relationships between SUA level and various clinical and biochemical parameters were analyzed. Results SUA level was positively associated with increased incidence of cardiovascular diseases (CVD) in patients with abnormal eGFR (<90 ml/min/1.73 m 2). HbA1c was found to be inversely associated with hyperuricemia in patients with normal eGFR level (90 ml/min/1.73 m 2). Incidence of metabolic syndrome did not show any relationship with SUA level. However, the incidence of hypertension, a component of metabolic syndrome, was significantly higher among patients with hyperuricemia. Waist circumference and serum triglycerides were increased, whereas serum high-density lipoprotein level was decreased in patients with higher SUA level. Patients with hyperuricemia had higher incidence of CVDs than those of the normouricemic group. Conclusion SUA level was positively associated with incidence of cardiovascular diseases CVD in patients with abnormal eGFR. HbA1c correlated significantly with SUA level in patients with normal eGFR.