Synthesis of 2,4,5-triaryl-imidazoles catalyzed by NiCl 2·6H 2O under heterogeneous system (original) (raw)
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Tetrahedron Letters, 2008
InCl 3 Á3H 2 O was found to be a mild and effective catalyst for the efficient, one-pot, three component synthesis of 2,4,5-trisubstituted imidazoles at room temperature. Moreover, the utility of this protocol was further explored conveniently for the one-pot, four component synthesis of 1,2,4,5-tetrasubstituted imidazoles in high yields.
RSC Adv., 2014
Trityl chloride (TrCl or Ph 3 CCl) efficiently catalyzes the one-pot multi-component condensation of benzil with aldehydes, primary amines and ammonium acetate under neutral and solvent-free conditions to give 1,2,4,5-tetrasubstituted imidazoles in high to excellent yields and in short reaction times. Mechanistically, it is attractive that trityl chloride promotes the reaction by in situ generation of trityl carbocation (Ph 3 C + ).
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This review is an updated and expanded version of imidazole represent an important class of heterocycles, which contains two hetero (nitrogen) atoms and two double bonds. There are so many compounds which contain Imidazole ring and exhibit different types of pharmacological and biological activities such as antimicrobial, antitumor, antiepileptic, and antihistaminic, anti oxidative, anti-inflammatory, anti diarrhoeal, analgesic, which has caused an excessive use of drugs.
One-pot synthesis of 2,4,5-tri-substituted-1H-imidazoles promoted by trichloromelamine
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2,4,5-Trisubstituted imidazoles have many pharmaceutical properties and can be prepared via reaction of 1, 2-diketones with aldehydes in the presence of an acidic catalyst. In this work, we have prepared 2,4,5-trisubstituted imidazoles in the presence of trichloromelamine as a source of positive chlorine. Short reaction times, high yield, simplicity of operation and easy work-up are some advantages of this method.
Arkivoc, 2012
The reaction of nitrones, formed in situ by reaction of hydroxylamines and aldehydes, with 2azido acrylates results in the formation of 1,2,4,5-tetrasubstituted imidazoles has been developed. This three-component reaction allows for the formation of a diverse array of imidazole derivatives with moderate to excellent yields.