32 Asian Journal of Chemistry 2011 (original) (raw)
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Limnophila polystachya Benth. is a herb belongs to the family Scrophulariaceae; widely used in traditional Indian medicine for various debilitating diseases such as pestilent fever, dysentery, elephantiasis, dyspepsia and also exhibits significant antibacterial, antifungal and antineoplastic activities. Preliminary photochemical screening on this plant showed that the presence of alkaloids, flavonoids, glycosides, steroids, tannins and terpenoids. The ethanolic extract of Limnophila polystachya was subjected to thin layer and column chromatography using petroleum ether:ethyl acetate in the ratio of (3.75:1.25) as solvent system for the isolation of bioactive phytoconstituents obtained after fractional crystallization using silica gel (60-120) mesh. The colourless crystalline compounds further purified using chromatographic methods and elucidated with spectral techniques such as UV, IR, 1H NMR, 13C NMR, elemental analysis and LCMS. The amorphous crystalline compound was elucidated as CH3-(CH2)30-COOH (Do-triacontanoic acid, Syn: lacceroic acid). Antibacterial activity was assessed on isolated crystals against gram negative and positive bacterial pathogenic organism. The elucidated crystals showed that significant activity against the pathogenic organisms at the diameter 600 and 1000 μg/mL at significant zone of inhibition. Lacceroic acid has been exhibited antibacterial activity against different pathogenic organism.
Limnophila rugosa Roth. (Merr.) (Scrophulariaceae), an ethno medicinal plant, is used as Bhringaraja by traditional practioners of Odisha. In the present study the leaves of L. rugosa were characterized for its physico-chemical properties and High Performance Thin Layer Chromatography, following standard procedures. The ethanol & aqueous extracts were subjected to various chemical tests and different types of functional groups like alkaloid, tannin, triterpenoids (Steroid), flavonoid, and phenols were detected. In Chromatography, HPTLC method, at different R f, 16 spots were detected under both long and short UV. The results, being reported could be useful in the identification and standardization of the crude drug.
Chemical and pharmacological aspects of Limnophila rugosa: An update
The present work offers a review addressing the chemistry and pharmacology of Limnophila rugosa (Roth) Merr. (belonging to Scrophulariaceae family) regarded as one of the most significant plant species in traditional system of medicine. The plant is used in the treatment of various ailments like pestilent fever, elephantiasis, diarrhoea, dysentery, dyspepsia etc. and is a diverse kind of chemical constituents such as phenolics, flavonoids, terpenoids, amino acids etc. The isolated phytochemicals as well as different extracts exhibited significant biological activities such as antimicrobial, anti-inflammatory, diuretic, hypotensive and effect on Guinea-pig ileum. Exhaustive research regarding isolation of more phytochemicals and pharmacology study on this medicinal plant is still necessary so as to explore the plant regarding its medicinal importance. Therefore, the aim of this review is to boost up present day researchers in this direction to undertake further investigation of this ...
ChemInform Abstract: Chemical Constituents of Limnophila indica
ChemInform, 2009
Two flavonoids, 5,6-dihydroxy-7,8,4'-trimethoxy flavone 1 and 5,2'-dihydroxy-8,3',4'-trimethoxyflavone 2 together with three known compounds, 5-hydroxy-7,2'-dimethoxyflavone 3, 5,2'-dihydroxy-7,8-dimethoxyflavone 4 and β-sitosterol 5, have been isolated from the aerial parts and roots of Limnophila indica (Scrophulariaceae). The structures of compounds 1-5 have been elucidated on the basis of spectral and chemical studies.
Limnophila Conferta (Scrophulariaceae): A review on chemical and medicinal importance
Limnophila conferta is an aquatic plant which is grown in muddy region. It is edible in many places like Chattisgarh, Bihar, Jharkhand and Orissa.The present paper deals with a detail literature review on Limnophila conferta which belonging to the family Scrophulariaceae. Taxonomy, isolated phytoconstituents and pharmacological application are described in paper. Various volatile oils are found in this plant like phellandrene, ocimene, farnesene, selinene, terpinene 4 ol etc and flavonoid nevadensin. Traditionally plant has been employed for treatment of skin diseases and swelling. Many experiments revealed that plant extract and isolated phytoconstituents are shown positive pharmacological activities on antimicrobial, antiinflammatory, anthelmintic, cytotoxic and wound healing activity. Key Words: Aquatic plant, Limnophila conferta, Limnophila genus, Muchri sag, Phytoconstituents
Chemical constituents of Limnophila indica
Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry, 2008
Two flavonoids, 5,6-dihydroxy-7,8,4'-trimethoxy flavone 1 and 5,2'-dihydroxy-8,3',4'-trimethoxyflavone 2 together with three known compounds, 5-hydroxy-7,2'-dimethoxyflavone 3, 5,2'-dihydroxy-7,8-dimethoxyflavone 4 and β-sitosterol 5, have been isolated from the aerial parts and roots of Limnophila indica (Scrophulariaceae). The structures of compounds 1-5 have been elucidated on the basis of spectral and chemical studies.
Chemical and pharmacological aspects of Limnophila geoffrayi: An update
The present work offers a review addressing the chemistry and pharmacology of Limnophila geoffrayi Bonati (belonging to Scrophulariaceae family) regarded as one of the most significant plant species in traditional system of medicine. The plant is used traditionally as an antipyretic, expectorant, lactogogue and to prepare a decoction as antidote for detoxification of poisons. Few phytochemical studies have been done so far on this plant. Thirteen chemical constituents have been reported from this plant and crude plant extracts as well as pure phytochemicals are reported to exhibit antimicrobial and antioxidant activities. Exhaustive research regarding isolation of more phytochemicals and pharmacology study on this medicinal plant is still necessary so as to explore the plant regarding its medicinal importance. Therefore, the aim of this review is to boost up present day researchers in this direction to undertake further investigation on this plant to find new ‘lead molecule’ in the ongoing drug discovery programme. The present review covers literature up to August 2014.
Limnophila rugosa Roth. (Merr) (Scrophulariaceae) is used as a botanical source of Bhringaraja by the traditional practitioners of Balangir and Baragarh district of Odisha. The present study was carried out to screen the preliminary phytochemical constituents of ethanol & aqueous extracts of the whole parts of L. rugosa including High Performance Thin Layer Chromatography. The extracts were subjected to various chemical tests in order to identify the main phytoconstituents of the plant. The study revealed that the ethanol extract contains glycosides, little amount of alkaloids and flavonoids where as the aqueous extract is rich in glycosides.
Journal of entomology and zoology studies, 2019
Present research was undertaken to investigate the chemical composition, total phenolics assay, in vitro antioxidant, anti-inflammatory and insect antifeeding activity in chloroform extract of Limnophila indica (L.) Druce. GC-MS analysis revealed the occurrence of 4,5-Dimethyl-1,2,3,6,7,8,8a,8boctahydrobiphenylene (18.3%) as a major compound. Total phenolic content, flavanoid content and orthodihydric phenol in the extract were 150.55±0.33 mg/g GAE, 40.72±0.69 mg/g CNE and 56.66±0.93 mg/g CLE, respectively. In-vitro antioxidant activity estimation through NO radical scavenging activity, DPPH radical scavenging activity, metal chelating activity of Fe and reducing power activity of Fe to Fe resulted its potential result with IC50 values of 35.85±3.12, 28.52±1.32, 49.29±0.15 and 39.17±0.65 respectively. Anti-inflammatory activity determined using inhibition of protein denaturation method and extract showed significant activity (IB50=27.96±1.14). Chloroform extract of L. indica at the ...