Novel Strategy to Fabricate Floating Drug Delivery System Based on Sublimation Technique (original) (raw)
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Potential of Floating Drug Delivery System as an Innovation
2021
The current research related to the formulation of the floating matrix tablets planned to enhance the drug bioavailability, extend the gastric residence time and reduce the side effects of irritating drugs, which are attained after oral administration. Gum arabic, sodium alginate, carrageenan, corn starch, gum guar, hydroxypropyl methylcellulose (HPMC), and polyacrylates were different types of matrix-forming polymers studied. As the type of matrix former the relative importance of drug diffusion, polymer swelling tablet erosion for the resulting release patterns varied significantly. The tablets eroded upon contact with the release medium. The purpose of this article is to evaluate modern technology used in the development of floating drug delivery system as well as summarizes the applications the advantages and disadvantages, characterization, estimation methods and future potential, principle of floating drug delivery system for floating tablets.
International journal of Pharmacy and Pharmaceutical Sciences, 2014
Objective: The purpose of this study was to prepare non-effervescent floating extended release matrix of Tramadol hydrochloride using polyethylene oxide (PEO) and a combination of cationic and anionic polymethacrylates polymers, Eudragit ® EPO (EE) and Eudragit ® Methods: Polymethacrylate polymer mixtures (PPM) in different polymer weight ratios (1:2, 1:1 and 2:1) were prepared by hot melt mixing process. Thermally treated PPM were evaluated by differential scanning calorimetry and fourier transform infrared spectroscopy for possible interpolyelectrolyte complex formation. The formulation variables like effects of polymethacryate ratios and their concentration, polymer types, PEO concentrations and compression force on release characteristics were investigated. The tablets were also evaluated for physicochemical properties,in vitro floating ability (floating lag-time and duration) and swelling properties. L100-55 (EL). Results: The optimized formulation with the combination of PEO and PPM (F4) showed instant floating properties, extended drug release properties for 14h and tablet remained buoyant for >24 h. Significant difference was observed in the effect of pH of dissolution media on drug release from formulations prepared using combination of PEO and PPM. The dissolution data of these matrices were fitted to different dissolution models. Non-Fickian release transport was confirmed as the drug release mechanism from the optimized formulation (F4). Conclusion: non-effervescent floating tablets were found a feasible approach for the sustained-release preparation of drugs, which have limited absorption sites in the stomach
Brazilian Journal of Pharmaceutical Sciences, 2014
The aim of the present research is to formulate and evaluate the gastroretentive floating drug delivery system of antihypertensive drug, propranolol HCl. Gastroretentive floating tablets (GRFT) were prepared by using a synthetic hydrophilic polymer polyethylene oxide of different grades such as PEO WSR N-12 K and PEO 18 NF as release retarding polymers and calcium carbonate as gas generating agent. The GRFT were compressed by direct compression strategy and the tablets were evaluated for physico-chemical properties, in vitro buoyancy, swelling studies, in vitro dissolution studies and release mechanism studies. From the dissolution and buoyancy studies, F 9 was selected as an optimized formulation. The optimized formulation followed zero order rate kinetics with non-Fickian diffusion mechanism. The optimized formulation was characterised with FTIR studies and observed no interaction between the drug and the polymers.
Design and evaluation of floating multi-layer coated tablets based on gas formation
European Journal of Pharmaceutics and Biopharmaceutics, 2008
Floating multi-layer coated tablets were designed based on gas formation. The system consists of a drug-containing core tablet coated with a protective layer (hydroxypropyl methylcellulose), a gas forming layer (sodium bicarbonate) and a gas-entrapped membrane, respectively. The mechanical properties of acrylic polymers (Eudragit Ò RL 30D, RS 30D, NE 30D) and ethylcellulose were characterized by the puncture test in order to screen a suitable film for the system. Eudragit Ò RL 30D was chosen as a gas-entrapped membrane due to its high flexibility and high water permeability. The obtained tablets enabled to float due to the CO 2-gas formation and the gas entrapment by polymeric membrane. The effect of formulation variables on floating properties and drug release was investigated. The floating tablets using direct-compressed cores had shorter time to float and faster drug release than those using wet-granulated cores. The increased amount of a gas forming agent did not affect time to float but increased the drug release from the floating tablets while increasing coating level of gas-entrapped membrane increased time to float and slightly retarded drug release. Good floating properties and sustained drug release were achieved. These floating tablets seem to be a promising gastroretentive drug delivery system.
The present study was designed to formulate and evaluate balanced Floating Drug Delivery Systems as controlled release modules, which prolongs the release rate of the drugs. Amoxycillin is an anti-bacterial acts by inhibiting the synthesis of bacterial cell walls. It inhibits cross-linkage between the linear peptidoglycan polymer chains that make up a major component of the cell walls of both Gram-positive and Gram-negative bacteria. Helicobacter pylori exists in the gastric mucous layer or epithelial cell surfaces. Thus, the concentration and resident time of Amoxycillin trihydrate in stomach would be effective for complete eradication of Helicobacter pylori. Formulation of Amoxycillin trihydrate as gastro retentive drug delivery systems (GRDDS) is especially advantageous over other prolonged type drug delivery systems and conventional tablets because the drug is having absorption window in upper part of gastro intestinal tract and having relatively short half life. Amoxycillin trihydrate was taken as the model drug to optimized formulations was prepared. The single unit floating matrix tablets of Amoxycillin trihydrate with different natural and synthetic polymers such has HPMC K4M, HPMC K15M, HPMC K100M by taking single polymer in the formulation.The evaluation of physicochemical characteristics of all formulations and to carryout in vitro drug release studies using USP XXIV apparatus and data were analyzed at 272nm.The drug release of Amoxycillin trihydrate from formulations containing HPMC K4M,HPMC K15M followed zero order kinetics where has formulation containing combination of xanthan gum(natural polymer) and HPMC K100M(synthetic polymer) followed Higuchi and First-order pattern respectively. Of all the formulations in which combination of polymers has retarded the drug successfully upto 12 hours.
Formulation , characterization and drug release kinetics of floating drug delivery systems
2015
The purpose of writing this review on floating drug delivery systems (FDDS) is to pile up the recent l iteratures with special focus on formulation, characterization and the prime mechanism of floatation to achieve gastri c retention, including kinetic consideration for FDDS. Drugs sho wing absorption window at a particular region has l imited surface area for absorption after oral administrati on. To overcome the limitations different dosage fo rms are formulated and it was observed that FDDS has the ab ility to be retained in the gastric environment for l nger period of time, favoring the absorption of drugs sh owing absorption window at gastric region. This pap er summarizes current approaches in the research and d evelopment, evaluation, along with formulation bene fits and limitations, and drug candidates suitable to be for mulated into ideal floating drug delivery systems. For predictability and reproducibility in designing an efficient floating dosage form, some kinetic studi...
FLOATING TABLETS: REVIEW ARTICLE
AAPS, 2019
The current research related to the formulationof the floating matrix tablets planned to enhance the drug bioavailability, extend the gastric residence time, and reduce the side effects of irritating drugs, which are attained after oral administration. Gum arabic, sodium alginate, carrageenan, corn starch, gum guar, hydroxypropyl methylcellulose (HPMC), and polyacrylateswere different types of matrix-forming polymers studied.As the type of matrix former the relative importance of drug diffusion, polymer swelling tablet erosion for the resulting release patterns varied significantly. The tablets eroded upon contact with the release medium.The purpose of this article is to evaluate modern technology used in the development of floating drug delivery system as well as summarizes the applications the advantages and disadvantages, characterization, estimation methods and future potential ,principle of floating drug delivery system for floating tablets. [1, 2]
A REVIEW ON CONTROLLED RELEASE FLOATING DRUG DELIVERY SYSTEMS IN PHARMACEUTICAL FORMULATIONS
EUROPEAN JOURNAL OF PHARMACEUTICAL AND MEDICAL RESEARCH, 2019
Over the years there has been available a variety of drug modification and dosage forms, with which we have attempted to control the time course and specificity of drugs in the body maximize drug utilization, it is necessary to deliver the drug to its target tissue in the correct amount at the proper time to elicit the desired response. The most convenient method of controlled delivery of drug is undoubtedly oral, but oral controlled release of the drug for an extended period of time that exhibits more absorption in stomach and upper small intestine, has not been successful with conventional approaches. Consequently, most research efforts have been focused on platforms to extend gastric residence time (GRT) of these drugs. The novel design of Oral Controlled Drug Delivery System(OCDDS) should be primarily aimed at achieving a more predictable and increased bioavailability of drugs. However, the development process is precluded by several physiological difficulties, such as inability to restrain and localize controlled drug delivery systems (CDDS) within the desired regions of the gastrointestinal (GI) tract and highly variable nature of the gastric emptying process. Thus, conventional OCDDS has not been suitable for a variety of important drugs which has any of above mentioned characteristics, which is mainly due to the relatively short transit time of the dosage form in the stomach and upper part of small intestine. The overall results are accompanied by lesser bioavailability. Furthermore, the relatively brief gastric emptying time in humans, which normally range from 2 - 3 hours through the major absorption zone (stomach or upper part of intestine), can result in incomplete drug release from the dosage form leading to diminished efficacy of the administered dose. Thus, control of placement of drug delivery system in a specific region of the GI tract offers numerous advantages. From the formulation and technological point of view, the Floating Drug Delivery System (FDDS) is considerably an easy and logical approach in the development of gastro retentive dosage forms. Hence in the present study, the formulation of Gastro Retentive Dosage Forms (GRDFs) is done by FDDS.
A Review on the Floating Drug Delivery System -Its Evaluations and Recent Works Done in 4-5 Years
International Journal of Pharmaceutical Sciences Review and Research, 2024
Since floating drug delivery systems may solve the disadvantages associated with traditional drug delivery systems, such as frequent dosing, limited bioavailability, etc., in comparison to quick stomach emptying time, they have attracted a lot of attention in recent decades. A system that stays in the stomach for an adequate amount of time and delivers the active medication continuously is known as an ideal floating drug delivery system. These continue to float over the stomach contents. prolonging the pharmacological effects and enhancing the drug's bioavailability. This overview of gastroretentive and floating tablets was written to gather recent research on the topic, as well as information on the floating tablets' principles, benefits, categorization, preparation, and assessment methods, and a list of medications that have been developed as floating tablets. formulation evaluation and future scope of floating tablets. The review concentrated on the types of floating medication delivery systems and the formulation aspect of effervescent floating drug delivery systems. The review's objective is to gather the research being done on this floating medicine delivery device. The review addresses several aspects that impact stomach retention (long duration) and offers useful information about the pharmaceutical formulation side of it.
Gastroretentive floating tablets: An investigation of excipients effect on tablet properties
MARMARA PHARMACEUTCAL JOURNAL, 2016
Present communication was aimed to investigate the effect of excipients on buoyancy and drug release properties from the floating tablets. Gastroretentive floating tablets were developed by the wet granulation method using hydroxypropyl methylcellulose (HPMC K4M), carbopol 934P and carbopol 971P as a rate controlling polymers and crospovidone as a dissolution enhancer. Sodium bicarbonate and citric acid were used as a gas generating agent. PVP K30 was used as granulating agent. The effect of formulation variables on tablet performance was examined quantitatively based on buoyancy properties, swelling behavior and drug release profiles. The drug release mechanism was investigated using mathematical models. It was found that HPMC/carbopol matrices at 1:1 ratio with crospovidone and sodium bicarbonate gave sustained and better drug release profile upto 24 h when compared to HPMC or carbopol matrices alone. The mechanism of drug release was found to be anomalous non Fickian.