Efficient guanidination of the phosphate linkage towards cationic phosphoramidate oligonucleotides (original) (raw)

Prevention of guanine modification and chain cleavage during the solid phase synthesis of oligonucleotides using phosphoramidite derivatives

Nassim Usman

Nucleic Acids Research, 1986

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Synthesis of Chimeric Oligonucleotides Containing Phosphodiester, Phosphorothioate, and Phosphoramidate Linkages

Andrei Guzaev

Organic Letters, 2000

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Synthesis and triple helix-forming ability of oligonucleotides with N,N-dimethylaminoethyl phosphoramidate linkages

Anna Grandas

Tetrahedron Letters, 1999

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Phosphoramidites and solid supports based on N-substituted 2,4-dihydroxybutyramides: universal reagents for synthesis of modified oligonucleotides

Dmitry Stetsenko

Tetrahedron, 2006

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A New Approach to Oligonucleotide N3′⇉P5′ Phosphoramidate Building Blocks

Sergei Gryaznov

Nucleosides, Nucleotides and Nucleic Acids, 2005

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Synthesis of oligodeoxyribonucleotide N3′→P5′ phosphoramidates

Ronald Schultz

Nucleic Acids Research, 1995

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Synthesis of modified oligonucleotides containing 4-guanidino-2-pyrimidinone nucleobases

Anna Grandas

Tetrahedron, 2001

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Solid-Phase Synthesis of Phosphorothioate/Phosphonothioate and Phosphoramidate/Phosphonamidate Oligonucleotides

Ondrej Kostov

Molecules, 2019

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New oligodeoxyribonucleotide derivatives bearing internucleotide N-tosyl phosphoramidate groups: Synthesis and complementary binding to DNA and RNA

Dmitry Stetsenko

Russian Journal of Bioorganic Chemistry, 2017

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[Functionalization of oligonucleotides containing internucleotide phosphoamide bonds]

Alexander Sinyakov

Bioorganicheskaia khimiia

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New oligodeoxynucleotide derivatives containing N-(methanesulfonyl)-phosphoramidate (mesyl phosphoramidate) internucleotide group

Dmitry Stetsenko

Russian Journal of Bioorganic Chemistry, 2017

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Oligonucleotide N3'-->P5' phosphoramidates

Sergei Gryaznov

Proceedings of the National Academy of Sciences, 1995

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alpha-Oligodeoxyribonucleotide N3'-->P5' phosphoramidates: synthesis and duplex formation

Sergei Gryaznov

Nucleic Acids Research, 1998

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Oligo-2'-fluoro-2'-deoxynucleotide N3'-->P5' phosphoramidates: synthesis and properties

Sergei Gryaznov

Nucleic Acids Research, 1996

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A New Method for the Preparation of Modified Oligonucleotides

Olga Gorchs, Anna Grandas

Organic Letters, 2002

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Phosphoramidite reagents and solid-phase supports based on hydroxyprolinol for the synthesis of modified oligonucleotides

Sergey Gontarev

Russian Journal of Bioorganic Chemistry, 2017

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arabino-Fluorooligonucleotide N3′→P5′ phosphoramidates: synthesis and properties

Sergei Gryaznov

Tetrahedron Letters, 2000

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An improved synthesis of oligodeoxynucleotide N34∀P54 phosphoramidates and their chimera using hindered phosphoramidite monomers and a novel handle for reverse phase purification

Mark Nguyen

2000

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A versatile reagent for the synthesis of 5′-phosphorylated, 5′-thiophosphorylated or 5′-phosphoramidate-conjugated oligonucleotides

Francois Morvan

Tetrahedron Letters, 2006

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Synthesis of oligonucleotides containing bulky adducts at guanine N2 via the phosphoramidite of O2-triflate-O6-NPE 2′-deoxyxanthosine

Richard Hodge

Tetrahedron Letters, 2000

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Oligonucleotides bearing cationic groups: N2-(3-aminopropyl)deoxyguanosine. Synthesis, enhanced binding properties and conjugation chemistry

Dan Cook

Tetrahedron Letters, 1996

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ChemInform Abstract: Oligonucleotides Bearing Cationic Groups: N2-(3-Aminopropyl) deoxyguanosine. Synthesis, Enhanced Binding Properties and Conjugation Chemistry

Dan Cook

Cheminform, 2010

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A Novel Thymidine Phosphoramidite Synthon for Incorporation of Internucleoside Phosphate Linkers During Automated Oligodeoxynucleotide Synthesis

Surong Zhang, David Tabatadze

Nucleosides, Nucleotides and Nucleic Acids, 2008

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Zwitterionic oligodeoxyribonucleotide N3'->P5' phosphoramidates: Synthesis and properties

Sergei Gryaznov

Nucleic Acids Research, 1998

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Oligonucleotide N3′→P5′ thiophosphoramidates: synthesis and properties

Sergei Gryaznov

Tetrahedron Letters, 1999

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Synthesis, biophysical properties, and nuclease resistance properties of mixed backbone oligodeoxynucleotides containing cationic internucleoside guanidinium linkages: Deoxynucleic guanidine/DNA chimeras

Dinesh Barawkar

Proceedings of the National Academy of Sciences, 1998

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On the Synthesis of Oligonucleotides Interconnected through Pyrophosphate Linkages

Nico Meeuwenoord

European Journal of Organic Chemistry, 2015

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A new approach to the synthesis of oligonucleotides and their phosphorothioate analogues in solution

Quanlai Song, Colin Reese

Bioorganic & Medicinal Chemistry Letters, 1997

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An improved synthesis of oligodeoxynucleotide N3'->P5' phosphoramidates and their chimera using hindered phosphoramidite monomers and a novel handle for reverse phase purification

Larry DeDionisio

Nucleic Acids Research, 1998

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Phosphotriester approach to the synthesis of oligonucleotides: a reappraisal

Colin Reese

Journal of the Chemical Society, Perkin Transactions 1, 1993

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A Convenient Synthesis of 5-Hydroxy-2′-Deoxycytidine Phosphoramidite and its Incorporation into Oligonucleotides

Jean Cadet

Tetrahedron Letters, 1997

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Synthesis of 2‘-O-[2-[(N,N-Dimethylamino)oxy]ethyl] Modified Nucleosides and Oligonucleotides

Guillermo Vasquez

The Journal of Organic Chemistry, 2002

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Stepwise synthesis of oligonucleotide–peptide conjugates containing guanidinium and lipophilic groups in their 3′-termini

Anna Aviñó

Bioorganic & Medicinal Chemistry Letters, 2010

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Selective O-phosphitilation with nucleoside phosphoramidite reagents

Sergei Gryaznov

Nucleic Acids Research, 1992

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Solid-Phase Synthesis of Modified Oligonucleotides

Ramon Eritja

International Journal of Peptide Research and Therapeutics, 2006

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