Prevention of guanine modification and chain cleavage during the solid phase synthesis of oligonucleotides using phosphoramidite derivatives (original) (raw)

Synthesis of Oligodeoxynucleotides Containing 2-Substituted Guanine Derivatives Using 2-Fluoro-2'-Deoxyinosine as Common Nucleoside Precursor

Ramon Eritja

Nucleos Nucleot Nucleic Acids, 1997

View PDFchevron_right

Synthesis of modified oligonucleotides containing 4-guanidino-2-pyrimidinone nucleobases

Anna Grandas

Tetrahedron, 2001

View PDFchevron_right

A New Method for the Preparation of Modified Oligonucleotides

Olga Gorchs, Anna Grandas

Organic Letters, 2002

View PDFchevron_right

Phosphoramidites and solid supports based on N-substituted 2,4-dihydroxybutyramides: universal reagents for synthesis of modified oligonucleotides

Dmitry Stetsenko

Tetrahedron, 2006

View PDFchevron_right

Synthesis of oligodeoxynucleotides containing 6-N-([13C]methyl)adenine and 2-N-([13C]methyl)guanine

Ramon Eritja

J Chem Soc Perkin Trans 1, 1997

View PDFchevron_right

Synthesis of oligonucleotides containing bulky adducts at guanine N2 via the phosphoramidite of O2-triflate-O6-NPE 2′-deoxyxanthosine

Richard Hodge

Tetrahedron Letters, 2000

View PDFchevron_right

Solid-Phase Synthesis of Modified Oligonucleotides

Ramon Eritja

International Journal of Peptide Research and Therapeutics, 2006

View PDFchevron_right

Phosphoramidite reagents and solid-phase supports based on hydroxyprolinol for the synthesis of modified oligonucleotides

Sergey Gontarev

Russian Journal of Bioorganic Chemistry, 2017

View PDFchevron_right

Chemical synthesis of biologically active oligoribonucleotides using β-cyanoethyl protected ribonucleoside phosphoramidites

Christopher Francklyn, Nassim Usman

Nucleic Acids Research, 1990

View PDFchevron_right

Duplex-Stabilization Properties of Oligodeoxynucleotides Containing N2-Substituted Guanine Derivatives

Ramon Eritja

Helvetica Chimica Acta, 2000

View PDFchevron_right

Efficient guanidination of the phosphate linkage towards cationic phosphoramidate oligonucleotides

Françoise Debart

Tetrahedron Letters, 2003

View PDFchevron_right

Nucleoside 3'-phosphotriesters as key intermediates for the oligoribonucleotide synthesis. IV. New method for removal of 2,2,2-trichioroethyl group and 31 NMR as a new tool for analysis of deblocking of intemucleotide phosphate protecting groups

Wojciech Markiewicz, Julia Seegers

Nucleic Acids Research, 1977

View PDFchevron_right

Fast oligonucleotide deprotection phosphoramidite chemistry for DNA synthesis

Huynh Vu

Tetrahedron Letters, 1990

View PDFchevron_right

SolidPhase synthesis of positively charged deoxynucleic guanidine (DNG) oligonucleotide mixed sequences

Mallikarjuna Reddy

Bioorganic & Medicinal Chemistry Letters, 2003

View PDFchevron_right

The 4-( N -Dichloroacetyl- N -methylamino)benzyloxymethyl Group for 2‘Hydroxyl Protection of Ribonucleosides in the SolidPhase Synthesis of Oligoribonucleotides

jon duff

Journal of Organic Chemistry, 2008

View PDFchevron_right

Nucleoside 3'phosphotriesters as key intermediates for the oligoribonucleotide synthesis. III. An improved preparation of nucleoside 3'-phosphotriesters, their 1H NMR characterization and new conditions for removal of 2-cyanoethyl group

Wojciech Markiewicz

Nucleic Acids Research, 1976

View PDFchevron_right

Solid-phase synthesis of base-sensitive oligonucleotides

Pasi Virta

Arkivoc, 2008

View PDFchevron_right

MODIFIED OLIGONUCLEOTIDES: Synthesis and Strategy for Users

Sandeep Verma

Annual Review of Biochemistry, 1998

View PDFchevron_right

Synthesis and triple helix-forming ability of oligonucleotides with N,N-dimethylaminoethyl phosphoramidate linkages

Anna Grandas

Tetrahedron Letters, 1999

View PDFchevron_right

Improved strategies for postoligomerization synthesis of oligodeoxynucleotides bearing structurally defined adducts at the N 2 position of deoxyguanosine

dimitrios tsarouhtsis

Chemical research …, 1996

View PDFchevron_right

3′-3′-linked oligonucleotides: Synthesis and stability studies

Carole Chaix

Bioorganic & Medicinal Chemistry Letters, 1996

View PDFchevron_right

Further studies on oligoribonucleotide synthesis

Wojciech Markiewicz

Nucleic Acids Symposium Series

View PDFchevron_right

The use of labile base protecting groups in oligoribonucleotide synthesis

Carole Chaix

Tetrahedron Letters, 1989

View PDFchevron_right

Phosphotriester approach to the synthesis of oligonucleotides: a reappraisal

Colin Reese

Journal of the Chemical Society, Perkin Transactions 1, 1993

View PDFchevron_right

A new approach to the synthesis of oligonucleotides and their phosphorothioate analogues in solution

Quanlai Song, Colin Reese

Bioorganic & Medicinal Chemistry Letters, 1997

View PDFchevron_right

Synthesis, biophysical properties, and nuclease resistance properties of mixed backbone oligodeoxynucleotides containing cationic internucleoside guanidinium linkages: Deoxynucleic guanidine/DNA chimeras

Dinesh Barawkar

Proceedings of the National Academy of Sciences, 1998

View PDFchevron_right

Synthesis of Chimeric Oligonucleotides Containing Phosphodiester, Phosphorothioate, and Phosphoramidate Linkages

Andrei Guzaev

Organic Letters, 2000

View PDFchevron_right

Synthesis of 2‘-O-[2-[(N,N-Dimethylamino)oxy]ethyl] Modified Nucleosides and Oligonucleotides

Guillermo Vasquez

The Journal of Organic Chemistry, 2002

View PDFchevron_right

2‘- O -[2-(Guanidinium)ethyl]-Modified Oligonucleotides: Stabilizing Effect on Duplex and Triplex Structures †

Thazha Prakash

Organic Letters, 2004

View PDFchevron_right

N-(2-Hydroxyethyl)phenazinium derivatives of oligonucleotides as effectors of the sequence-specific modification of nucleic acids with reactive oligonucleotide derivatives

Olga Fedorova

FEBS Letters, 1988

View PDFchevron_right

Selective O-phosphitilation with nucleoside phosphoramidite reagents

Sergei Gryaznov

Nucleic Acids Research, 1992

View PDFchevron_right

Synthesis of 2′- N -Methylamino-2′-deoxyguanosine and 2′- N , N -Dimethylamino-2′-deoxyguanosine and Their Incorporation into RNA by Phosphoramidite Chemistry

Qing Dai

The Journal of Organic Chemistry, 2011

View PDFchevron_right

ChemInform Abstract: Oligonucleotides Bearing Cationic Groups: N2-(3-Aminopropyl) deoxyguanosine. Synthesis, Enhanced Binding Properties and Conjugation Chemistry

Dan Cook

Cheminform, 2010

View PDFchevron_right

A Comparative Study of Supports for the Synthesis of Oligonucleotides Without Using Ammonia

Anna Aviñó

Nucleosides and Nucleotides, 1996

View PDFchevron_right

Diastereomers of a mono-substituted phosphoryl guanidine trideoxyribonucleotide: Isolation and properties

Dmitry Stetsenko

Biochemical and Biophysical Research Communications, 2019

View PDFchevron_right