Fourth Belgian multicentre survey of antibiotic susceptibility of anaerobic bacteria (original) (raw)
Related papers
Antimicrobial susceptibility of anaerobic bacteria in New Zealand: 1999-2003
Journal of Antimicrobial Chemotherapy, 2006
Objectives: Routine susceptibility testing of all anaerobic organisms is not advocated, but it is useful for laboratories to test periodically for anaerobic organisms and provide local susceptibility data to guide therapy. This study reports the national trend of antibiotic susceptibility of clinically significant anaerobes in New Zealand.
Resistance Trends in Antimicrobial Susceptibility of Anaerobic Bacteria, Part I
Clinical Microbiology Newsletter, 2011
Despite the suggestions of both the Clinical and Laboratory Standards Institute (CLSI) and the American Society for Microbiology (ASM) Manual of Clinical Microbiology that hospitals should test individual patient isolates to assist in their care, periodically establish patterns of resistance for certain anaerobes, and include these data in the hospital antibiogram, anaerobic susceptibility studies are performed in only a minority of clinical laboratories and their patterns of susceptibility are obtainable mostly from published surveys conducted by a small number of research centers scattered worldwide. The Bacteroides fragilis group species, the most frequently studied anaerobes, have been reported to vary in their frequencies of resistance to all antimicrobial agents worldwide. Limited data exist about the resistance patterns of other genera and species. Part I of this two-part article reviews the methods used for anaerobic susceptibility testing and the correlation of in vitro susceptibility test results with clinical data and antimicrobial resistance that has been reported for gram-negative and gram-positive anaerobes. Part II of this article will review mechanisms of resistance among anaerobes to commonly used antimicrobial agents.
Antimicrobial susceptibility of anaerobic bacteria in Bulgaria
Anaerobe, 2009
Objectives: The antimicrobial susceptibility of anaerobic bacteria isolated from clinical specimens in the referent for Bulgaria anaerobic laboratory was studied in a period of 25 years/1983-2007/. Methods: NCCLS-recommended agar dilution methods were used. b-lactamase activity was determined with nitrocefin discs. Results: The 29 antimicrobial agents included in the study were divided according to their in vitro activity against the anaerobic isolates into 4 main groups for guiding empirical treatment: 1st group of metronidazole, chloramphenicol, meropenem, imipenem and combinations of b-lactam antibiotics with sulbactam-with high activity and drugs of choice for treatment; 2nd group-clindamycin, cefoxitin, carbenicillin/and azlocillin, piperacillin/-with a good activity and low percent of resistant strains; 3rd group-of tetracycline and erythromycin with higher percent of resistant strains including the new macrolides as josamycin, clarithromycin, roxithromycin and azithromycin; 4th group-penicillins/ ampicillin, amoxicillin, penicillin/and cephalosporins/cefamandole, cefazolin, cefotaxime and cefoperazone/-not suitable for treatment of infections including Bacteroides fragilis group strains, with a very high percent of resistant strains, probably due to b-lactamase activity in most of the strains. Conclusion: A continued updating and a follow-up in the changes of antibiotic susceptibility are necessary in every country as resistance patterns vary not only between geographical regions but also even among medical centers and hospitals which may be connected with differences in antibiotic usage in man and animals.
Survey of anaerobic susceptibility patterns: A French multicentre study
International Journal of Antimicrobial Agents, 1998
In 1996, the in vitro antibiotic susceptibility of 463 anaerobes was measured in five hospitals using the reference agar dilution method. None of the 209 B. fragilis group strains showed resistance to imipenem or ticarcillin-clavulanic acid. High resistance rates (29%) were observed for cefotetan and clindamycin. i-Lactamase production was detected respectively in 64% of the Pre6otella and 7% of the Fusobacterium strains. Because the same standardized methods were used for many years, the authors were able to evaluate the evolution of antibiotic resistance. Clindamycin resistance had increased within the B. fragilis group (from 14% in 1992 to 29% in 1996) and also among strains of clostridia (32%), P. acnes (18%) and Peptostreptococcus (28%). In the B. fragilis group multidrug resistance was unlikely to occur.
Anaerobe, 2008
A total of 60 anaerobic strains were isolated from 322 clinical specimens. These isolates were tested for susceptibility to seven antibiotics (penicillin G, amoxicillin/clavulanic acid, cefoxitin, imipenem, chloramphenicol, metronidazole, clindamycin) by using ATB-ANA and Epsilometer test (E-test) strips and the results were compared with the gold standard agar dilution method. Imipenem was found as the most effective agent in vitro among the agents tested (100%). Susceptibility to penicillin G, amoxicillin/ clavulanic acid, cefoxitin, chloramphenicol, metronidazole and clindamycin are 36.7%, 83.3%, 88.3%, 96.6%, 85% and 90%, respectively. E-test has showed a good correlation (r ¼ 0.62, p ¼ 0.001) statistically with the results of agar dilution (total agreement for all antibiotics changing between 90.01% and 98.45%) and a moderate correlation (r ¼ 0.45, p ¼ 0.048) with the results of ATB-ANA method (total agreement for all antibiotics changing between 75.46% and 98.76%). However, the routine use of agar dilution procedure is concluded to be cumbersome, whereas E-test method offers a reliable alternative.
Antibiotics
Local antimicrobial susceptibility surveys are crucial for optimal empirical therapy guidelines and for aiding in antibiotic stewardship and treatment decisions. For many laboratories, a comprehensive overview of local antimicrobial susceptibility patterns of anaerobic bacteria is still lacking due to the long incubation time and effort involved. The present study investigates the antimicrobial susceptibility patterns and related clinical and demographic data of 2856 clinical isolates of anaerobic bacteria that were submitted for analysis to the Institute for Medical Microbiology and Hygiene of the Freiburg University Medical Center (a tertiary university medical center in Southern Germany) between 2015 and 2019. Antimicrobial susceptibility testing has been carried out according to the European Committee on Antimicrobial Susceptibility Testing (EUCAST) guideline. Minimum inhibitory concentration (MIC)50 and MIC90 for penicillin, metronidazole, moxifloxacin, and clindamycin were est...
Southern African Journal of Infectious Diseases, 2008
Antibiotic resistance amongst previous(v susceptible anaerobic bacteria has increased during the last decade, raising concerJls about tlte choice of empirical therapy. ill tltis study, Etest methodology and Clinical Laboratory Standards Institute guidelines were used for processing and interpretation of minimum inhihitory concentration values for anaerobic bacteria obtained over a one-year period from two teaching JW.l;pitals in Pretoria, South Africa. From tlie datu obtained, tlie genera Bacteroides, Clostridium and Peptostreptococcns were most frequently isolated. The ~-lactam;P-Iactamase inhibitor combination, piperacillinltazobactam seems to be the superior choice as empiric therapy lor suspected serious anaerubic infections in this setting. In addition, a definite increase in resistance against metronidazole was exhibited by isolates originatinglrom invasive samples, making the drug an unlikely cltoice lorluture empiric therapy.