Antidiarrheal Activity of the Aqueous Extract of Punica granatum . (Pomegranate) Peels (original) (raw)
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Antidiarrhoeal activity of rind of Punica granatum
International Current Pharmaceutical Journal, 2013
Punica granatum (Family: Punicaceae) is a widely consumed fruit in Bangladesh locally known as Anar or Bedana. Traditionally the plant is used to treat diarrhoea, dysentery, hemorrhage, tuberculosis and chronic periodontitis. The present study was undertaken in order to justify and authenticate the traditional use of rind of P. granatum fruit in diarrhoea. Methanolic extract of the rind of the fruit was tested in castor oil- and magnesium sulfate-induced diarrhoea in mice at the doses of 200 and 400 mg/kg body weight. The results of the present study revealed significant antidiarrhoeal activity (p<0.001) in both animal models. The extract inhibited 31.25% defaecation at the dose of 200 mg/kg and 53.75% at the dose of 400 mg/kg in castor oil-induced diarrhoea while standard drug loperamide inhibited 71.25% defaecation. In magnesium sulfate-induced diarrhoea the inhibition of defaecation was 45.71 and 57.14% at the doses of 200 and 400 mg/kg respectively while loperamide inhibited ...
International Journal of Applied Pharmaceutics, 2021
Objective: Diarrheal disease and its complications remain a major cause of morbidity and mortality in children, especially in developing countries. It is usually a symptom of an infection in the intestinal tract, which can be caused by a variety of bacterial, viral, parasitic or organisms. The purpose of this study was to determine the activity and dose of white pomegranate peel (Punica granatum L.) ethanol extract as an antidiarrheal in white male mice using the intestinal transit method. Methods: Mice were grouped into 5 groups: negative control (Na CMC 1 %), positive control (loperamide HCl 0.0104 mg/20 g mice BW), and pomegranate peel ethanol extract test group 1, 2, and 3 (dose of 16, 32, and 64 mg/20 g mice BW). The length of the intestine that the ink marker traversed from the pylorus to the end (which is black) was measured using a ruler. Results: Based on statistical analysis, there were significant differences between all groups (<0.05). The highest antidiarrheal activity was in the ethanolic extract of pomegranate peel at a dose of 64 mg/20 g mice BW with an inhibition percentage of 36.44% and higher than the positive control (29.81%). The inhibition percentage was also resulted by dose 1 and 2 (12.46% and 29.53%, respectively). Conclusion: From these results show a correlation that the higher the extract dose, the higher the antidiarrheal potential.
Evaluation of antidiarrhoeal potential of Punica granatum L. (Puniacaceae) in Ayurvedic formulation
Many Ayurvedic antidiarrhoeal formulations contain Punica granatum L, (Puniacaceae) as one of the ingredient. Efficacy of Punica granatum L. in polyherbal antidiarrhoeal formulation was evaluated by comparing its antidiarrhoeal activity with Mebarid; an antidiarrhoeal Ayurvedic formulation. Antidiarrhoeal effect of an aqueous extract of rinds of fruits of Punica granatum (APG) and Mebarid was studied in castor oil induced diarrhoea, intestinal secretion and charcoal meal test in mice. APG significantly reduced diarrhoea and also produced antimotility and antisecretory activity in castor oil model. These results indicate that APG is an active ingredient of Mebarid in treating diarrhoea.
Recent Patents on Inflammation & Allergy Drug Discovery, 2018
Background: Punica granatum L. (pomegranate), is a shrub mostly available in the Mediterranean Sea region. The fruits have gained the substantial attention among researchers due to their promising biological activities including anti-inflammatory, antibacterial, antidiarrheal, immune modulatory, antitumor, wound healing and antifungal that have been attributed to various constituents of seeds, bark, juice, pericarp, and leaf of this tree across the globe. The phenolic compounds of pomegranate have been documented to possess numbers of prophylactic and therapeutic utilities against various pathological infections as well as non-infectious disorders. Objective: The current review expedites the pharmacological role of Punica granatum L. in curing elements related to infectious and non-infectious disorders. Method: The current review is based on literature and patents already available on various scientific databases highlighting the role of Punica granatum along with its therapeutic potentials against infectious and non-infectious disorders. The databases included under study were PubMed, Med line, PubMed Central, Science Direct and few other scientific databases. The information obtained through these diverse databases is compiled, critically interpreted and presented in the current study. Results: Multi-dimensional beneficial application of pomegranate plant is recorded. The pomegranate seed oil has phytoestrogenic compounds and the fruit is rich in phenolic compounds with strong antioxidant activity. The fruit and bark of pomegranate are used against intestinal parasites, dysentery, and diarrhea in different animals and human models. Since the ancient time the juice and seeds had considered the best therapy for throat and heart disorders. Ellagic acid is one of the main components of pomegranate with potent antioxidant activity. Results from different studies reported that Punica granatum L or its byproducts can be used as natural food additives in human and animal nutrition in order to boost immunity, microbial safety and provide the housing environment without affecting body weight gain. In addition, Punica granatum L. byproducts can modulate immune function and gut microbiota of broiler chickens as well as reduce the odorous gas emissions from ex-creta. Naturally occurring polyphenols in a pomegranate can be a potential alternative medicine for the prevention of avian Colibacillosis diseases and can also be used as an intestine astringent to relieve diarrhea and enteri-tis in chickens. Conclusion: The present review gives the insight towards major components of pomegranate as well as their pharmacological activities against pathological disorders. In spite of many beneficial properties of Punica granatum L., more research evidence on a molecular basis is needed to find out the molecular mechanism of action in various animals and human models to validate the usefulness of Punica granatum L. as a potent therapeutic agent.
Herbal medicines as the major remedy in traditional system of medicine have been used in medical practices since antiquity. In addition to its ancient historical uses, pomegranate is used in several systems of medicine for a variety of ailments. The objective of the present study was to investigate the presence of various phytochemicals from the ethanolic, aqueous and chloroform extracts of Punica granatum peel, whole fruit and seeds. The three different extracts from peel were found to contain Triterpenoids, Steroids, Glycosides, Flavonoids, Tannins, Carbohydrate & Vitamin C. The three different extracts from whole fruit were found to contain Triterpenoids, Steroids, Glycosides, Saponins, Alkaloids, Flavonoids, Tannins, Carbohydrate & Vitamin C. The three different extracts from seeds were found to contain Triterpenoids, Steroids, Glycosides, Saponins, Alkaloids, Tannins, Carbohydrate & Vitamin C. The generated data from the three different extracts of Punica granatum peel, whole fruit & seeds provided the basis for its wide uses in the traditional & folk medicines.
Anti-Ulcerogenic Activity of the Pomegranate Peel (<i>Punica granatum</i>) Methanol Extract
Food and Nutrition Sciences, 2013
Pomegranate (Punica granatum L.) belongs to genera Punica and family Punicaceae. It is a herbal preparation that has been suggested as useful in the treatment of gastrointestinal disorders. However, to our knowledge, no study has been conducted to evaluate this therapeutic property. In the present study the antiulcerogenic effects of pomegranate peel methanol extract, was tested on male Wistar albino rats. Oral pretreatment with peel extracts (25, 50 and 100 mg/kg) for 15 days protected the gastric mucosa against the damage induced by indomethacin (50 mg/kg). The incidence of ulceration in the control group was 100%. The best results were found in a dosage of 50 mg/kg in sour summer cultivar which inhibited the peptic ulcerin comparison with indomethacin induced gastric ulcer group. Lowest ulcer index (5.4 ± 0.55), an apparent decrease in the infiltration of polymorphonuclear leukocytes and hemorrhage were observed after administration of sour summer extracts (50 mg/kg). In conclusion present study showed that pomegranate peel extract, especially sour summer, has curative potential as an antiulcer, possibly via its high antioxidant activity. These results from pomegranate peel extract can provide an extra income and may contribute about good nutritional values of this product.
Journal of Health and Allied Sciences NU
Herbal medicines as the major remedy in traditional system of medicine have been used in medical practices since antiquity. In addition to its ancient historical uses, pomegranate is used in several systems of medicine for a variety of ailments. The objective of the present study was to investigate the presence of various phytochemicals from the ethanolic, aqueous and chloroform extracts of Punica granatum peel, whole fruit and seeds. The three different extracts from peel were found to contain Triterpenoids, Steroids, Glycosides, Flavonoids, Tannins, Carbohydrate & Vitamin C. The three different extracts from whole fruit were found to contain Triterpenoids, Steroids, Glycosides, Saponins, Alkaloids, Flavonoids, Tannins, Carbohydrate & Vitamin C. The three different extracts from seeds were found to contain Triterpenoids, Steroids, Glycosides, Saponins, Alkaloids, Tannins, Carbohydrate & Vitamin C.The generated data from the three different extracts of Punica granatum peel, whole fr...
Anti-Ulcerative Potential of Punica granatum L (Lythraceae) Hydroalcohol Fruit Peel Extract
Tropical Journal of Pharmaceutical Research, 2014
Methods: Male Wistar rats, 175 -220 g, were fasted for 48 h, but had free access to water. They were randomly divided into nine experimental groups. Ulcer was induced in the rats with 80 % ethanol. The control group animals received the same treatment as those in the test groups except that the extract treatment was replaced by administration of appropriate volume of the dosing vehicle. Histaminereceptor type-2 (H2) blocker, cimetidine (100 mg/kg, i.p.) was used as the reference drug. Oral pretreatment with three different extract doses (25, 50 and 100 mg/kg) was for 15 days, thereafter, ulcer index (UI) and inhibition were calculated. Results: The extract, at 50 mg/kg, of black fruit peel extract produced significant (p < 0.05) protective effect in rats with a preventive index of 65.87 %. Other doses were significantly protective against ethanol-induced gastric ulcer in the rats. On the other hand, north white peel was not effective (50 mg/kg) showed an ulcer index of 49.52 ± 1.99. Histopathological examination of the stomach of the ulcerated animals treated with white peel (50 mg/kg) showed severe erosion of gastric mucosa, submucosal edema and neutrophil infiltration. Conclusion: The study shows indicates the antiulcer properties of the methanol extracts of north white peel, sour summer and black peel (25, 50, 100 mg/kg) of pomegranate. Their antiulcer activity is exerted, possibly, via its high antioxidant activity.
Therapeutic Effects of Punica granatum (Pomegranate): An Updated Review of Clinical Trials
Journal of Nutrition and Metabolism
Punica granatum L. belongs to the Punicaceae family which is distributed around the world. Different parts of pomegranate like seed, peel, juice, and leaves are rich in potential bioactive compounds. These plants have found application in traditional medicine such as in treatment of gastrointestinal, cardiovascular, and endocrine diseases, among others. The present review aimed to summarize the current research on the traditional and scientific applications of P. granatum with regard to the phytochemical content and clinical applications that may be useful for future drug development. Information about P. granatum was obtained from local classic herbal literature and electronic databases, such as PubMed, Scopus, and ScienceDirect. Several phytochemical constituents including polyphenolics, flavonoids, anthocyanosides, alkaloids, lignans, and triterpenes have been reported from the plant. Randomized clinical trials have provided evidence as to the pharmacological activities of pomegr...