G protein-effector coupling: interactions of recombinant inhibitory γ-subunit with transducin and phosphodiesterase (original) (raw)

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Retinal cyclic-GMP phosphodiesterase γ-subunit: Use of mutant synthetic peptides to define function

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Biochemical and Biophysical Research Communications, 1991

Identification of a binding site on retinal transducin α for the phosphodiesterase inhibitory γ subunit

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Modulation of retinal transducin and phosphodiesterase activities by synthetic peptides of the phosphodiesterase γ-subunit

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FEBS Letters, 1987

Interactions of a G-protein with its effector: transducin and cGMP phosphodiesterase in retinal rods

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Residues within the polycationic region of cGMP phosphodiesterase gamma subunit crucial for the interaction with transducin alpha subunit. Identification by endogenous ADP-ribosylation and site-directed mutagenesis

Kirk Yousif

The Journal of biological chemistry, 1997

The N Terminus of GTPγS-activated Transducin α-Subunit Interacts with the C Terminus of the cGMP Phosphodiesterase γ-Subunit

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Journal of Biological Chemistry, 2006

Different Properties of the Native and Reconstituted Heterotrimeric G Protein Transducin †

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Biochemistry, 2008

β-Subunits of the human liver Gs/Gi signal-transducing proteins and those of bovine retinal rod cell transducin are identical

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FEBS Letters, 1986

γ-Subunit of mouse retinal cyclic-GMP phosphodiesterase: cDNA and corresponding amino acid sequence

FEBS Letters, 1988

cGMP phosphodiesterase of retinal rods is regulated by two inhibitory subunits

P. Deterre

Proceedings of the National Academy of Sciences, 1988

Sites of interaction between rod G-protein alpha-subunit and cGMP-phosphodiesterase gamma-subunit. Implications for the phosphodiesterase activation mechanism

Journal of Biological Chemistry, 1992

GTP‐dependent binding of Gi, Go and Gs to the γ‐subunit of the effector of Gt

Minh Vương

FEBS Letters, 1994

Sites of interaction between rod G-protein α-subunit and cGMP-phosphodiesterase γ-subunit: Implications for the phosphodiesterase activation mechanism

Journal of Biological Chemistry

The positive role of the carboxyl terminus of the γ subunit of retinal cGMP-phosphodiesterase in maintaining phosphodiesterase activity in vivo

Vision Research, 2002

Low Affinity Interactions of GDPbeta S and Ribose- or Phosphoryl-substituted GTP Analogues with the Heterotrimeric G Protein, Transducin

J. Angleson

Journal of Biological Chemistry, 1996

Role for the target enzyme in deactivation of photoreceptor G protein in vivo

Peter Calvert

Science (New York, N.Y.), 1998

Cloning and sequencing of the γ-subunit of retinal cyclic-GMP phosphodiesterase from rd mouse

Renu Tuteja

Experimental Eye Research, 1989

The effector enzyme regulates the duration of G protein signaling in vertebrate photoreceptors by increasing the affinity between transducin and RGS protein

The Journal of biological chemistry, 2000

Transducin activates cGMP phosphodiesterase by trapping inhibitory γ subunit freed reversibly from the catalytic subunit in solution

Satoru Kawamura

Scientific Reports

Asymmetric Interaction between Rod Cyclic GMP Phosphodiesterase γ Subunits and αβ Subunits

Arnold Ruoho

Journal of Biological Chemistry, 2005

In vivo differential prenylation of retinal cyclic GMP phosphodiesterase catalytic subunits

Janmeet Anant

Journal of Biological Chemistry, 1992

N-terminal Half of the cGMP Phosphodiesterase -Subunit Contributes to Stabilization of the GTPase-accelerating Protein Complex

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Journal of Biological Chemistry, 2011

RGS9-Gbeta 5 Substrate Selectivity in Photoreceptors. OPPOSING EFFECTS OF CONSTITUENT DOMAINS YIELD HIGH AFFINITY OF RGS INTERACTION WITH THE G PROTEIN-EFFECTOR COMPLEX

J Biol Chem, 2001

Affinities of bovine photoreceptor cGMP phosphodiesterases for rod and cone inhibitory subunits

J. Kelley Bentley

FEBS Letters, 1993

Cloning of a cyclic GMP phosphodiesterase γ subunit from the ground squirrel retina

Molecular Brain Research, 1998

Identification and Characterization of a Cyclic di-GMP-specific Phosphodiesterase and Its Allosteric Control by GTP

Alexandra Schauerte

Journal of Biological Chemistry, 2005

Binding of cGMP to the transducin-activated cGMP phosphodiesterase, PDE6, initiates a large conformational change involved in its deactivation

Fumio Hayashi

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In vitro isoprenylation and membrane association of mouse rod photoreceptor cGMP phosphodiesterase α and β subunits expressed in bacteria

Ning Qin

The Journal of Biological Chemistry, 1992

A Constitutively Active Gα Subunit Provides Insights into the Mechanism of G Protein Activation

Garima Singh

Biochemistry, 2012

The GTPase activating factor for transducin in rod photoreceptors is the complex between RGS9 and type 5 G protein subunit

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Proceedings of the National Academy of Sciences, 1999

The human rod photoreceptor cGMP phosphodiesterase β-subunit

Boris Shmukler

FEBS Letters, 1993

The GTPase activating factor for transducin in rod photoreceptors is the complex between RGS9 and type 5 G protein β subunit

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Proceedings of the National Academy of Sciences, 1999