The effector enzyme regulates the duration of G protein signaling in vertebrate photoreceptors by increasing the affinity between transducin and RGS protein (original ) (raw )The GTPase activating factor for transducin in rod photoreceptors is the complex between RGS9 and type 5 G protein β subunit
Jason Handy
Proceedings of the National Academy of Sciences, 1999
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The GTPase activating factor for transducin in rod photoreceptors is the complex between RGS9 and type 5 G protein subunit
elina makino
Proceedings of the National Academy of Sciences, 1999
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Role for the target enzyme in deactivation of photoreceptor G protein in vivo
Peter Calvert
Science (New York, N.Y.), 1998
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Interactions of a G-protein with its effector: transducin and cGMP phosphodiesterase in retinal rods
P. Deterre
Cellular Signalling, 1993
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RGS9-Gbeta 5 Substrate Selectivity in Photoreceptors. OPPOSING EFFECTS OF CONSTITUENT DOMAINS YIELD HIGH AFFINITY OF RGS INTERACTION WITH THE G PROTEIN-EFFECTOR COMPLEX
Nikolai Skiba
J Biol Chem, 2001
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RGS9-Gβ5 Substrate Selectivity in Photoreceptors
Nikolai Skiba
Journal of Biological Chemistry, 2001
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N-terminal Half of the cGMP Phosphodiesterase -Subunit Contributes to Stabilization of the GTPase-accelerating Protein Complex
Lian-wang Guo , Arnold Ruoho
Journal of Biological Chemistry, 2011
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Timing Is Everything: GTPase Regulation in Phototransduction
Theodore Wensel
Investigative Opthalmology & Visual Science, 2013
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High expression levels in cones of RGS9, the predominant GTPase accelerating protein of rods
Theodore Wensel
Proceedings of the National Academy of Sciences, 1998
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GTP‐dependent binding of Gi, Go and Gs to the γ‐subunit of the effector of Gt
Minh Vương
FEBS Letters, 1994
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cGMP influences guanine nucleotide binding to frog photoreceptor G-protein
Phyllis Robinson
The Journal of biological chemistry, 1986
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Regulation of transducin GTPase activity in bovine rod outer segments
Nikolai Skiba
Journal of Biological Chemistry, 1994
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GAP-Independent Termination of Photoreceptor Light Response by Excess Subunit of the cGMP-Phosphodiesterase
Debora Farber
Journal of Neuroscience, 2006
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The molecular architecture of photoreceptor phosphodiesterase 6 (PDE6) with activated G protein elucidates the mechanism of visual excitation
Feixia Chu
Journal of Biological Chemistry, 2019
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Modules in the Photoreceptor RGS9-1· Gβ 5L GTPase-accelerating Protein Complex Control Effector Coupling, GTPase Acceleration, Protein Folding, and Stability
Wei He
2000
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A Constitutively Active Gα Subunit Provides Insights into the Mechanism of G Protein Activation
Garima Singh
Biochemistry, 2012
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The N Terminus of GTPγS-activated Transducin α-Subunit Interacts with the C Terminus of the cGMP Phosphodiesterase γ-Subunit
Arnold Ruoho
Journal of Biological Chemistry, 2006
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Site-specific Phosphorylation of Phosducin in Intact Retina: DYNAMICS OF PHOSPHORYLATION AND EFFECTS ON G PROTEIN DIMER BINDING
Craig Thulin
Journal of Biological Chemistry, 2004
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Transducin β-Subunit Can Interact with Multiple G-Protein γ-Subunits to Enable Light Detection by Rod Photoreceptors
Nikolai Skiba
ENeuro, 2018
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GTPase Regulators and Photoresponses in Cones of the Eastern Chipmunk
rod ney
2003
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R9AP, a membrane anchor for the photoreceptor GTPase accelerating protein, RGS9-1
Theodore Wensel
Proceedings of the National Academy of Sciences, 2002
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G protein-effector coupling: interactions of recombinant inhibitory .gamma. subunit with transducin and phosphodiesterase
Debora Farber
Biochemistry, 1989
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G protein-effector coupling: interactions of recombinant inhibitory γ-subunit with transducin and phosphodiesterase
Debora Farber
Biochemistry, 1989
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Kinetics and energetics of the rhodopsin-transducin-cGMP phosphodiesterase cascade of visual transduction
Minh Vương
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1992
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Transducin activates cGMP phosphodiesterase by trapping inhibitory γ subunit freed reversibly from the catalytic subunit in solution
Satoru Kawamura
Scientific Reports
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Interaction of retinal guanylate cyclase with the α subunit of transducin: potential role in transducin localization
Derek Rosenzweig
Biochemical Journal, 2009
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Light-dependent phosphorylation of the gamma subunit of cGMP-phophodiesterase (PDE6γ) at residue threonine 22 in intact photoreceptor neurons
Stephen Tsang
Biochemical and Biophysical Research Communications, 2009
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Binding of cGMP to the transducin-activated cGMP phosphodiesterase, PDE6, initiates a large conformational change involved in its deactivation
Fumio Hayashi
FEBS Journal, 2011
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A Possible Role of RGS9 in Phototransduction. A BRIDGE BETWEEN THE cGMP-PHOSPHODIESTERASE SYSTEM AND THE GUANYLYL CYCLASE SYSTEM
Fumio Hayashi
Journal of Biological Chemistry, 1998
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The positive role of the carboxyl terminus of the γ subunit of retinal cGMP-phosphodiesterase in maintaining phosphodiesterase activity in vivo
Debora Farber
Vision Research, 2002
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RGS9, a GTPase Accelerator for Phototransduction
Theodore Wensel
Neuron, 1998
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Cloning of a cyclic GMP phosphodiesterase γ subunit from the ground squirrel retina
Debora Farber
Molecular Brain Research, 1998
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Determination of basal phosphodiesterase activity in mouse rod photoreceptors with cGMP clamp
Ari Koskelainen
Scientific Reports
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