Liposomal drug delivery systems: From concept to clinical applications ☆ (original) (raw)
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Progress with liposomal drug delivery systems: Formulation to therapy
2014
The closed bilayer phospholipid systems likely called liposomes, were first described in 1965 by Alec Bangham and soon were accepted as drug delivery systems. Work on liposomes by number of researchers led the technical advances. These advances have led to numerous clinical trials and studies in such diverse areas as the delivery of anti-cancer, anti-fungal and anti-biotic drugs, the delivery of gene medicines and drug delivery to site of action, long circulating PEGylated liposomes, triggered release liposomes and liposomes containing combinations of drugs. This review is a focus on recent advances and some of the relevant challenges faced in developing clinically relevant liposomal drug carriers. The main objective of pharmaceutical science is to design and develop dosage forms with fulfilling the therapeutic need of the patients effectively. The writing highlights all aspects of liposomes starting from compositions to therapeutic applications and strategies through preparation an...
Liposomal Drug Delivery Systems: An Update Review
Current Drug Delivery, 2007
The discovery of liposome or lipid vesicle emerged from self forming enclosed lipid bi-layer upon hydration; liposome drug delivery systems have played a significant role in formulation of potent drug to improve therapeutics. Recently the liposome formulations are targeted to reduce toxicity and increase accumulation at the target site. There are several new methods of liposome preparation based on lipid drug interaction and liposome disposition mechanism including the inhibition of rapid clearance of liposome by controlling particle size, charge and surface hydration. Most clinical applications of liposomal drug delivery are targeting to tissue with or without expression of target recognition molecules on lipid membrane. The liposomes are characterized with respect to physical, chemical and biological parameters. The sizing of liposome is also critical parameter which helps characterize the liposome which is usually performed by sequential extrusion at relatively low pressure through polycarbonate membrane (PCM). This mode of drug delivery lends more safety and efficacy to administration of several classes of drugs like antiviral, antifungal, antimicrobial, vaccines, anti-tubercular drugs and gene therapeutics. Present applications of the liposomes are in the immunology, dermatology, vaccine adjuvant, eye disorders, brain targeting, infective disease and in tumour therapy. The new developments in this field are the specific binding properties of a drug-carrying liposome to a target cell such as a tumor cell and specific molecules in the body (antibodies, proteins, peptides etc.); stealth liposomes which are especially being used as carriers for hydrophilic (water soluble) anticancer drugs like doxorubicin, mitoxantrone; and bisphosphonate-liposome mediated depletion of macrophages. This review would be a help to the researchers working in the area of liposomal drug delivery.
LIPOSOMAL DRUG DELIVERY SYSTEM: AN OVERVIEW
Shodhasamhita : Journal of Fundamental & Comparative Research, 2022
Liposomes were the first nanoscale drug to be approved for clinical use in 1995.A major advancement in liposome-based delivery methods has been made since that time, and these advancements have important therapeutic consequences. For example, this comprises liposomes that can remain in the body for a lengthy period of time, liposomes that can be nebulized and elastic liposomes that can be used for topical, oral, and transdermal distribution. In contrast to liposomes, existing guidance on novel delivery strategies has not been well-documented. Liposomal delivery systems are described in detail, along with the regulatory landscape surrounding commercialization efforts for higher-level complexity systems, expected requirements, and obstacles faced by companies looking to bring novel liposome-based systems to market for clinical use, in this in-depth assessment.
Liposomal drug delivery: Recent developments and challenges
Pharmaspire
The spherical vesicles known as liposomes may contain one or many phospholipid bilayers. The first liposomes were found in the 1960s. One of the many distinctive drug delivery methods is the liposome, which offers a complex way to transfer active molecules to the site of action. Clinical trials are now testing a variety of formulations. Long-lasting second-generation liposomes are created by altering the vesicle’s lipid composition, size, and charge. Superficial vesicles have given way to liposome growth. Glycolipids and other substances have been used to make liposomes for the modification of outer surfaces through various types of targeting ligands and detecting agents or moiety. Now, the liposomes developed for the different market and it is flooded with cosmetics and, more crucially, medications. Three of the main applications of liposome technology include steric and environmental stabilization of loaded molecules, remote drug loading through pH and ion gradients approach, and ...
RECENT ADVANCES ON LIPOSOMAL DRUG DELIVERY SYSTEM: A REVIEW
A liposome is an artificially-prepared vesicle composed of a lipid bilayer. The liposome can be used as a vehicle for administration of nutrients and pharmaceutical. Liposomes are composed of natural phospholipids, and may also contain mixed lipid chains with surfactant properties. The major types of liposomes are the multilamellar vesicle, the small unilamellar vesicle, and the large unilamellar vesicle. Liposomal formulations were significantly explored over the last decade for the Anticancer Therapy, Respiratory drug delivery system, Nucleic acid therapy, ophthalmic drug delivery applications, Vaccine adjuvant, Anti-infective, Brain Targeting therapy. These formulations are mainly composed of phosphatidylcholine and other constituents such as cholesterol and lipid-conjugated hydrophilic polymers. Liposomes are biodegradable and biocompatible in nature. In this review article we summarize information about some of the key advantages of liposome, mechanism of liposomal formation, classification of liposomes, and application of liposome.
Review on Liposomes as a Drug Delivery System
DrSriram Publications, 2023
Nanoparticle systems have been perceived as the ultimate goal for effective drug delivery for decades. The ideal nanoparticle carries the drug-load safely to a predefined target. There, it is capable of releasing its cargo intracellular or in the extracellular space where the drug can be directly internalized and exert the desired action. Enroute, the nanoparticle prevents unwanted interactions of the drug-load with non-target tissues and where needed, it will enhance the circulation time of the encapsulated drug and enable sustained release. In this context, liposomes, a class of synthetic lipid nanoparticles have been explored in depth. Liposomes are microscopic self-assembling unilamellar or multilamellar vesicles made up of phospholipid bilayer. Both the hydrophilic and hydrophobic drugs can be attached to the lipid bilayer of liposomes and can show their efficacy in the target cell of the human body. Liposomes can significantly alter the pharmacokinetics of drugs. They have been investigated for diverse applications such as treatment of cancer, delivery of gene and vaccine, treatment of lung and skin diseases, treatment of tumours, and imaging tumours at the site of infection. They are leading present-day smart delivery systems due to their flexible biophysical and physicochemical properties, which permit easy control to address different delivery concerns. This review will discuss various advances and updates in liposome-assisted drug delivery and the current clinical use of liposomes for biomedical applications.
International Journal of Applied Pharmaceutics, 2017
Liposomes are an efficient novel drug delivery system. They are used because of their structure which is stable and due to their ability to accommodate both lipophilic and hydrophilic drug. Various fascinating types of liposomes have been developed in recent past to further enhance their utility. Long-circulating liposomes or stealth liposomes are able to hide from the defence system of the body and circulate for a longer time in the blood. Targeted liposomes namely immuno-liposomes consists of antibodies conjugated on their surface to improve the specificity of the cell. Liposomes have been modified as per the conditions of pH and temperature, specifically designed to improve drug delivery to targeted tumor cells. Liposomes are being used in the treatment of various diseases and there are various liposomal drug formulations available today. Liposomes can be used as carriers for genetic materials such as antisense, DNA, RNA which are useful in the treatment of diseases. Liposomes are also efficient carriers of cytokines which further activate macrophages. This review provides the detailed insight of types and applications of liposomes and the potential challenges in the development of liposomal drug delivery systems.
Pharmaceutical Liposomal Drug Delivery: A Complete Review of New Delivery System
2021
When a self-forming enclosed lipid bi-layer was hydrated, the liposome or lipid vesicle was discovered. Liposome drug delivery systems have played a key role in the development of powerful drugs that have improved therapies Liposome formulations have recently been aimed at reducing toxicity and increasing accumulation at the target site The suppression of rapid liposome clearance by regulating particle size, charge, and surface hydration is one of several new liposome manufacturing methods based on lipid drug interactions and liposome disposition mechanisms. Targeting tissue with or without expression of target recognition molecules on the lipid membrane is the most common clinical use of liposomal drug delivery. Physical, chemical, and biological factors are used to characterise the liposomes. Liposome size is another important metric that helps describe the liposome, which is normally done by successive extrusion at different temperatures. Several groups of medications, such as an...