Protein Kinase C: An Attractive Target for Cancer Therapy
Roberta Ricciarelli, Barbara Marengo
2011
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Protein kinase C inhibitors as novel anticancer drugs
Peter Goekjian
Expert Opinion on Investigational Drugs, 2001
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Rapid screening method for inhibitors of protein kinase C
Hiroyuki Osada
The Journal of Antibiotics, 1988
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Structural analogies between protein kinase C activators
Véronique Cabiaux
Biochemical and Biophysical Research Communications, 1985
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Tumor promotion by depleting cells of protein kinase C delta
Shigeo Ohno
Molecular and cellular biology, 1997
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Efficacy of natural inhibitors against pkc: an in silico approach to combat cancer
Farrukh Jamal
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Regulation and role of the atypical pkc isoforms in cell survival during tumor transformation
M. Diaz-Meco
Advances in Enzyme Regulation, 2001
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Fine Tuning of Protein Kinase C (PKC) Isoforms in Cancer: Shortening the Distance from the Laboratory to the Bedside
Mini-Reviews in Medicinal Chemistry MRMC
Bentham science
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Analysis of the phorbol ester pharmacophore on protein kinase C as a guide to the rational design of new classes of analogs
Konrad Koehler
Proceedings of the National Academy of Sciences, 1986
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Equivocal, explicit and emergent actions of PKC isoforms in cancer
Peter Parker
Nature Reviews Cancer, 2020
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Protein Kinase C as a Therapeutic Target
Beverly Teicher
Clinical Cancer Research, 2006
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The Pros and Cons of Targeting Protein Kinase c (PKC) in the Management of Cancer Patients
Alejandro Urtreger
Current Pharmaceutical Biotechnology, 2011
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Comparison of Effects of Bryostatins 1 and 2 and 12-O-Tetradecanoylphorbol-13-acetate on Protein Kinase C Activity in A549 Human Lung Carcinoma Cells
Ian Dale
Cancer Research, 1989
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Spontaneous occurrence of an inhibitor of protein kinase C localization in a thyroid cancer cell line: role in thyroid tumorigenesis
Deborah Schechtman
Advances in Enzyme Regulation, 2001
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Protein kinase C desensitization by phorbol esters and its impact on growth of human breast cancer cells
Romano Regazzi
Biochemical and Biophysical Research Communications, 1986
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Down-regulation of protein kinase C activity in 1,2-dimethylhydrazine-induced rat colonic tumors
R. Wali
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1991
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The Transition from a Pharmacophore-Guided Approach to a Receptor-Guided Approach in the Design of Potent Protein Kinase C Ligands
Kassoum Nacro
Pharmacology & Therapeutics, 1999
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Inhibitory activity and selectivity of staurosporine derivatives towards protein kinase C
Helmut Mett
Bioorganic & Medicinal Chemistry Letters, 1994
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Structural investigation of protein kinase C inhibitors
Dov Barak
Journal of Molecular Structure-theochem, 1991
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SupportedSpecificity , and Correlation with Drug Cytotoxicity 1 of Protein Kinase C : Structural Requirements , Isoform-Benzyladriamycin-14-valerate with the C 1-Regulatory Domain N Interaction of the Novel Anthracycline Antitumor Agent
Leonard Lothstein
2014
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Structural and functional diversities of a family of signal transducing protein kinases, protein kinase C family; two distinct classes of PKC, conventional cPKC and novel nPKC
Shigeo Ohno
Advances in Enzyme Regulation, 1991
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Protein kinase C - a question of specificity
Peter Parker
Trends in Biochemical Sciences, 1994
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Inhibition of protein kinase C arrests proliferation of human tumors
Vicente Felipo
FEBS Letters, 1991
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PKC-δ inhibits anchorage-dependent and -independent growth, enhances differentiation, and increases apoptosis in CaCo-2 cells
sharad khare
Gastroenterology, 2001
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Tumor Promotion by Depleting Cells of Protein Kinase Cd
Armand Hornia
1997
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Differential selectivity of ligands for the C1a and C1b phorbol ester binding domains of protein kinase Cdelta: possible correlation with tumor-promoting activity
Gerhardt Wagner
Cancer research, 1998
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Protein kinase C α and δ are members of a large kinase family of high potential for novel anticancer targeted therapy
F. Lokiec
Targeted Oncology, 2006
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Exploitation of protein kinase C: A useful target for cancer therapy
Philip Philip
Cancer Treatment Reviews, 2009
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Inhibition of rodent protein kinase C by the anticarcinoma agent dequalinium
Lan Bo Chen
Cancer research, 1990
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Differential Localization of Protein Kinase C δ by Phorbol Esters and Related Compounds Using a Fusion Protein with Green Fluorescent Protein
Kassoum Nacro
Journal of Biological Chemistry, 1999
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Cancer-Associated Protein Kinase C Mutations Reveal Kinase’s Role as Tumor Suppressor
Frank Furnari, Tony Hunter
Cell, 2015
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Domain interactions in protein kinase C
Peter Parker
2000
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A comparative study of the effect of the antineoplastic ether lipid 1-O-octadecyl-2-O-methyl-glycero-3-phosphocholine and some homologous compounds on PKCα and PKCɛ
Pablo Conesa Zamora
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2005
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Evaluation of (2S,4S)/(2R,4R) and (2S,4R)/(2R,4S) 6,6-N,N-dimethyl-2-methyl-2-oxo-1,3-dioxa-4-hexadecyl-6,aza-2-phosphacyclooctane bromide as inhibitors for protein kinase C, carnitine octanoyltransferase, and carnitine palmitoyltransferase
Rona Ramsay
Bioorganic & Medicinal Chemistry Letters, 1994
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Interaction of the novel anthracycline antitumor agent N-benzyladriamycin-14-valerate with the C1-regulatory domain of protein kinase C: structural requirements, isoform specificity, and correlation with drug cytotoxicity
Leonard Lothstein
Molecular cancer therapeutics, 2002
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