Focal inflammatory diseases of the liver (original) (raw)
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Diffuse disease of the liver: radiologic-pathologic correlation
RadioGraphics, 1994
Cross-sectional imaging is playing an increasing role in diagnosis of diifuse liver diseases because it clarifies, in many cases, the overlap in clinical and laboratory manifestations often present in diffuse hepatic processes and thus may eliminate the need for a biopsy. Advances in crosssectional imaging, particularly in magnetic resonance (MR) imaging, enable further characterization of hepatic parenchymal and architectural changes, allowing closer correlation with underlying pathologic changes. Advanced imaging techniques can be used to characterize a Variety of metabolic, vascular, toxic, infectious, and neoplastic diffuse liver diseases. These include more common entities such as cirrhosis, Budd
ROLE OF MRI IN CHARACTERIZATION OF FOCAL LIVER LESIONS
National Journal of Medical Research, 2020
Introduction: The increasing and widespread use of imaging studies has led to an increase in detection of incidental Focal Liver Lesions. It is important to diagnose not only malignant liver lesions, but also benign solid and cystic liver lesions. Objectives: Role of MRI imaging in characterization of various focal liver lesions detected incidentally on Ultrasonography. Methods: The present study included 50 patients with various focal Liver Lesions detected incidentally on Ultrasonography. MRI Liver of the patients having incidentally detected Focal Liver Lesions on Ultrasonography and Inconclusive Ultrasonography findings was done to characterize the various focal liver lesions. Biopsy was done in patients with findings raising a possibility of a malignant lesion. Result: Of the 50 patients, 30 patients were male and 20 were female. Age of patients ranged from 1 year to 79 years. Spectrum of diseases based on imaging findings includes: Simple hepatic cyst (5/50, 10%), Hemangioma(5/50, 10%) , Focal nodular hyperplasia(2/50, 4%), Hydatid cyst(4/50, 8%), abscess(3/50, 6%), hepatocellular carcinoma(9/50, 18%), metastases(12/50, 24%) and indeterminate radiological diagnosis(10/50, 20%). USG guided liver biopsy was done in 31 patients revealed Hepatocellular carcinoma in 7, Cholangiocarcinoma in 2, metastases in 20 patients and Hepatic adenoma in 2 patients. Conclusion: MRI has an excellent lesion detection rate. Nearly all the lesions detected on Ultrasonography were detected on MRI imaging. MRI is excellent for the characterization of various Focal Liver Lesions. It was possible to reach to a specific radiological diagnosis in most of the patients.
Sarcoidosis of the liver: Evaluation with multiple imaging modalities
Computerized Medical Imaging and Graphics, 1992
Although sarcoidosis of the liver is common pathologically, imaging findings are extremely rare, because the noncaseating granulomas are usually not macroscopic and thus do not produce focal abnormalities. We present 2 cases of liver sarcoidosis with focal findings on computed tomography, magnetic resonance imaging, nuclear scanning, and ultrasonography. Imaging characteristics, which may facilitate making the diagnosis, are presented.
CT and MRI of diffuse liver disease
Seminars in Ultrasound, CT and MRI, 1995
CT and MRI contribute important information to the clinical evaluation of diffuse liver disease. In some cases, these modalities can establish a diagnosis that was not ascertained histologically, which is often the case when sampling errors prevent a definitive tissue diagnosis. Characteristic alterations of liver attenuation on CT, signal changes on MRI, and morphological changes appreciated with both modalities can be used to diagnose fatty infiltration, some parenchymal deposition diseases, and cirrhosis. Furthermore, hepatocellular disease can be confirmed in the setting of indeterminate clinical and laboratory findings. Significant overlap in the imaging findings of this wide range of disorders continues to limit specificity; however, at a minimum, these techniques provide a rapid means to a noninvasive evaluation that often guides clinical decisions. Faster scanning techniques available with CT and MRI may provide additional information by assessing contrast dynamics. This review of CT and MRI in diffuse liver disease considers the diagnostic utility and clinical implications of these modalities. Pathological findings relevant to imaging considerations are discussed.
Focal Lesions of the Liver and Radiomics: What Do We Know?
Diagnostics
Despite differences in pathological analysis, focal liver lesions are not always distinguishable in contrast-enhanced magnetic resonance imaging (MRI), contrast-enhanced computed tomography (CT), and positron emission tomography (PET). This issue can cause problems of differential diagnosis, treatment, and follow-up, especially in patients affected by HBV/HCV chronic liver disease or fatty liver disease. Radiomics is an innovative imaging approach that extracts and analyzes non-visible quantitative imaging features, supporting the radiologist in the most challenging differential diagnosis when the best-known methods are not conclusive. The purpose of this review is to evaluate the most significant CT and MRI texture features, which can discriminate between the main benign and malignant focal liver lesions and can be helpful to predict the response to pharmacological or surgical therapy and the patient’s prognosis.
Medical Ultrasonography
In this series of papers on comments and illustrations of the World Federation for Medicine and Biology (WFUMB) guidelines on contrast enhanced ultrasound (CEUS) the topics of bacterial infections are discussed. Improved detection and characterization of common focal liver lesions (FLL) are the main topics of these guidelines but detailed and illustrating information is missing. The focus in this paper on infectious (bacterial) focal liver lesions is on their appearance on B-mode and Doppler ultrasound and CEUS features. Knowledge of these data should help to raise awareness of these rarer findings, to think of these clinical pictures in the corresponding clinical situation, to interpret the ultrasound images correctly and thus to initiate the appropriate diagnostic and therapeutic steps in time.
Background: Liver abscess is a serious problem especially in tropical regions like the Indian subcontinent. Itsignificant mortality and also poses diagnostic and therapeutic challenges. Present study describes the clinical, pathological and radiological profile of liver abscess patients attending the tertiary care hospital during the study period. Aims & Objectives: To Study a Clinico-Pathological profileand Radiological Characteristics of liver abscess patients.Methods:This is Prospective study was carried out in Total of 120 cases of liver abscess were included in the study.Statistical Analysis: All the data analysis was done using IBMSPSS version 20 software. Data is expressed as percentage and mean ± SD. Student t test and analysis of variance was used to tabulate the data. P value of <0.05 is considered as significant.Results:The age of patients ranged from 16 to 82 years. Out of 120 patients, 107 were males and 13 were females with a Male to female ratio of 8.23:1. The most common presentation of Liver Abscess was fever,abdomen pain & malaise which were present in 94.2%, 90.8%& 90 % in our patients respectively and signs like tender hepatomegaly and pallor were 75% and 73.33% respectively. Fever with chills and abdomen were most common in 21-40 age group and Nausea, weight loss and Anorexia were most common in 41-60 age groups. The right lobe(80%) was most commonly involved. Abscess was most commonly solitary (57.5%). Maximum patients had abscess size between 100-300mL (75%). In relation to aetiology, amoebicliver abscess was the most common type. Investigations found that 64 cases (53.3%) were amoebic in origin, 56 cases (46.7 %)were pyogenic in origin.Pyogenic liver abscess 44 (78.5%) was generally multiple in type.Conclusion:In present study most common symptoms like fever, abdomen pain, malaise wheretender hepatomegaly& pallor was most common signs. In younger age groups fever with chills and abdomen pain was most common due to good immunity where in older age groups non-specific symptoms were most common. Most common aetiology associated with abscess was amoebic which is solitary in type and maximum size belong to more than 100 mL in radiological characteristic where Pyogenic liver abscess is generally multiple in type and smaller size in radiological appearance.
Recent technologic advances have significantly enhanced the role of imaging in the detection, characterization, and management of infectious diseases involving the liver. In addition, imaging-guided percuta-neous drainage has greatly improved the clinical treatment of patients with focal liver abscess. Infectious liver diseases can be accurately evaluated with ultrasonography (US), computed tomography (CT), and magnetic resonance (MR) imaging. Characteristic changes in US echogenicity, CT attenuation, or MR imaging signal intensity and typical enhancement patterns can contribute to the diagnosis of specific infectious diseases, including abscesses, parasitic diseases, fungal diseases , granulomatous diseases, viral hepatitis, and other less common infections. CT is particularly helpful in revealing the presence of calci-fications and gas and in detailing the enhancement pattern. The multi-planar capability of MR imaging and its sensitivity to small differences in tissue composition increase its specificity for certain hepatic infections , including hydatid cyst and candidiasis. Radiologic findings may be sufficient to obviate aspiration or histologic examination, although in most instances they are less specific. Nevertheless, imaging findings taken together with appropriate clinical information may provide the most likely diagnosis, even if biopsy is sometimes required for confirmation .
Medical ultrasonography, 2023
In this series of papers on comments and illustrations of the World Federation for Medicine and Biology (WFUMB) guidelines on contrast enhanced ultrasound (CEUS) the topics of parasitic and fungus infections are discussed. Improved detection and characterization of common focal liver lesions (FLL) are the main topics of these guidelines but detailed and illustrating information is missing. The focus in this paper on infectious (parasitic and fungus) focal liver lesions is on their appearance on B-mode and Doppler ultrasound and CEUS features. Knowledge of these data should help to raise awareness of these rarer findings, to think of these clinical pictures in the corresponding clinical situation, to interpret the ultrasound images correctly and thus to initiate the appropriate diagnostic and therapeutic steps in time.