The effects of the trinitrophenylation of the amino groups of glucagon on its conformational properties and on its ability to activate rat liver adenylyl cyclase (original) (raw)

The Journal of biological chemistry, 1981

Non-equivalence of the carboxyl groups of glucagon in the carbodiimide-promoted reaction with nucleophiles and the role of carboxyl groups in the ability of glucagon to stimulate the adenyl cyclase of rat liver

Biochimica et Biophysica Acta (BBA) - General Subjects, 1974

Effect of specific trinitrophenylation of the lysine epsilon amino group of glucagon on receptor binding and adenylate cyclase activation

Archives of Biochemistry and Biophysics, 1983

Lipolytic and adenyl-cyclase-stimulating activity ofN ?-trinitrophenyl glucagon: Comparison with other glucagon derivatives modifed at the amino terminus

Bioscience Reports, 1982

Receptor binding and adenylate cyclase activities of glucagon analogs modified in the N-terminal region

Biochemistry, 1986

Comparative efficacy of seven synthetic glucagon analogs, modified in position 1, 2 and/or 12, on liver and heart adenylate cyclase from rat

Magali Waelbroeck

Peptides, 1986

Conformational and biological properties of glucagon fragments containing residues 1-17 and 19-29

International Journal of Peptide and Protein Research, 1983

The role of nonspecific hydrophobic interactions in the biological activity of N epsilon-acyl derivatives of glucagon. Studies of conformation, receptor binding, and adenylate cyclase activation

The Journal of biological chemistry, 1982

Conformational and biological properties of di[delta-(5-nitro-2-pyrimidyl)ornithine 17,18]glucagon. Role of the arginine residues

The Journal of biological chemistry, 1983

The glucagon receptor of rat liver plasma membrane can couple to adenylate cyclase without activating it

Robin Hesketh

Biochimica Et Biophysica Acta-biomembranes, 1976

Hormone action at the membrane level. I. Properties of adenyl cyclase in isolated plasma membranes of rat liver

vittorio tomasi

Biochimica et Biophysica Acta (BBA) - Biomembranes, 1970

Binding of a glucagon photoaffinity label to rat liver plasma membranes and its effect on adenylate cyclase activity before and after photolysis

Biochemistry, 1982

The relation of predicted structure to observed conformation and activity of glucagon analogs containing replacements at positions 19, 22, and 23

William Macaulay

The Journal of biological chemistry, 1987

Structure-activity studies of hydrophobic amino acid replacements at positions 9, 11 and 16 of glucagon

The Journal of Peptide Research, 2009

Semisynthetic glucagon derivatives for structure-function studies

Metabolism, 1976

Conformational and biological properties of a covalently linked dimer of glucagon. Reaction of mono- and bifunctional sulfenyl halides

Biochimica et biophysica acta, 1976

Activation of rat liver adenylate cyclase by guanosine 5′-[β,γ-imido]triphosphate and glucagon. Existence of reversibly and irreversibly activated states of the stimulatory GTP-binding protein

Skf Wong

Biochemical Journal, 1986

Adenylate cyclase in the rat pancreas properties and stimulation by hormones

willem rutten

Biochimica Et Biophysica Acta-biomembranes, 1972

The essential role of the imidazole group of glucagon in its biological function

Archives of Biochemistry and Biophysics, 1973

Structure activity studies on the N-terminal region of glucagon

Valentine Lance

Journal of Medicinal Chemistry, 1984

N-Ethylmaleimide uncouples the glucagon receptor from the regulatory component of adenylyl cyclase

Kenneth Lipson

Biochemistry, 1986

The Role of Phenylalanine at Position 6 in Glucagon's Mechanism of Biological Action: Multiple Replacement Analogues of Glucagon

Journal of Medicinal Chemistry, 1997

Glucagon amino groups. Evaluation of modifications leading to antagonism and agonism

Journal of Biological Chemistry, 1980

Stimulation and inhibition of cAMP accumulation by glucagon in canine hepatocytes

Journal of Biological Chemistry, 1987

Glucagon and epinephrine stimulation of adenyl cyclase in isolated rat liver plasma membranes

vittorio tomasi

Biochemical and Biophysical Research Communications, 1969

Differential acid stabilities of citraconylated amino groups of glucagon Preparation of Nα-Citraconyl glucagon and evaluation of its biological properties

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1982

Inhibition of the glucagon stimulated adenylate cyclase activity by insulin

Zoltan Kiss

FEBS Letters, 1978

Glucagon antagonists: contribution to binding and activity of the amino-terminal sequence 1-5, position 12, and the putative alpha-helical segment 19-27

Cecilia Unson

The Journal of biological chemistry, 1989

Metabolic effects and cyclic AMP levels produced by glucagon, (1-Nα-trinitrophenylhistidine,12-homoarginine)glucagon and forskolin in isolated rat hepatocytes

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1984

Superactive amidated COOH-terminal glucagon analogues with no methionine or tryptophan

Valentine Lance

Peptides, 1986

Direct Evidence of a Glucagon-Dependent Regulation of the Concentration of Glucagon Receptors in the Liver

Angel Santos

European Journal of Biochemistry, 1982

Structure-function relationships of S-carboxymethyl methionine27 glucagon

Kathleen Cornely

Archives of Biochemistry and Biophysics, 1985

Synthesis and isolation of a glucagon antagonist

FEBS Letters, 1979

Synthetic peptide antagonists of glucagon

Cecilia Unson

Proceedings of the National Academy of Sciences, 1987

Topographical Amino Acid Substitution in Position 10 of Glucagon Leads to Antagonists/Partial Agonists with Greater Binding Differences

Victor Hruby is to

Journal of Medicinal Chemistry, 1996