Effect of specific trinitrophenylation of the lysine epsilon amino group of glucagon on receptor binding and adenylate cyclase activation (original) (raw)

The Journal of biological chemistry, 1981

Receptor binding and adenylate cyclase activities of glucagon analogs modified in the N-terminal region

Biochemistry, 1986

The effects of the trinitrophenylation of the amino groups of glucagon on its conformational properties and on its ability to activate rat liver adenylyl cyclase

Biochimica et biophysica acta, 1975

Glucagon amino groups. Evaluation of modifications leading to antagonism and agonism

Journal of Biological Chemistry, 1980

Binding of a glucagon photoaffinity label to rat liver plasma membranes and its effect on adenylate cyclase activity before and after photolysis

Biochemistry, 1982

Lipolytic and adenyl-cyclase-stimulating activity ofN ?-trinitrophenyl glucagon: Comparison with other glucagon derivatives modifed at the amino terminus

Bioscience Reports, 1982

Semisynthetic glucagon derivatives for structure-function studies

Metabolism, 1976

The Role of Phenylalanine at Position 6 in Glucagon's Mechanism of Biological Action: Multiple Replacement Analogues of Glucagon

Journal of Medicinal Chemistry, 1997

Comparative efficacy of seven synthetic glucagon analogs, modified in position 1, 2 and/or 12, on liver and heart adenylate cyclase from rat

Magali Waelbroeck

Peptides, 1986

Synthesis and isolation of a glucagon antagonist

FEBS Letters, 1979

The role of nonspecific hydrophobic interactions in the biological activity of N epsilon-acyl derivatives of glucagon. Studies of conformation, receptor binding, and adenylate cyclase activation

The Journal of biological chemistry, 1982

Glucagon antagonists: contribution to binding and activity of the amino-terminal sequence 1-5, position 12, and the putative alpha-helical segment 19-27

Cecilia Unson

The Journal of biological chemistry, 1989

Structure-activity studies of hydrophobic amino acid replacements at positions 9, 11 and 16 of glucagon

The Journal of Peptide Research, 2009

Structure activity studies on the N-terminal region of glucagon

Valentine Lance

Journal of Medicinal Chemistry, 1984

Topographical Amino Acid Substitution in Position 10 of Glucagon Leads to Antagonists/Partial Agonists with Greater Binding Differences

Victor Hruby is to

Journal of Medicinal Chemistry, 1996

Non-equivalence of the carboxyl groups of glucagon in the carbodiimide-promoted reaction with nucleophiles and the role of carboxyl groups in the ability of glucagon to stimulate the adenyl cyclase of rat liver

Biochimica et Biophysica Acta (BBA) - General Subjects, 1974

Identification of the glucagon receptor by covalent labeling with a radiolabeled photoreactive glucagon analog

Biochemistry Usa, 1982

Synthetic peptide antagonists of glucagon

Cecilia Unson

Proceedings of the National Academy of Sciences, 1987

Search for bioactive conformation of glucagon and development of potent glucagon antagonists

Jung-mo Ahn

2000

The relation of predicted structure to observed conformation and activity of glucagon analogs containing replacements at positions 19, 22, and 23

William Macaulay

The Journal of biological chemistry, 1987

des His 1, des Phe 6, Glu 9]glucagon amide: A newly designed “pure” glucagon antagonist

Clinton David

Bioorganic & Medicinal Chemistry Letters, 1995

Differential acid stabilities of citraconylated amino groups of glucagon Preparation of Nα-Citraconyl glucagon and evaluation of its biological properties

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1982

Superactive amidated COOH-terminal glucagon analogues with no methionine or tryptophan

Valentine Lance

Peptides, 1986

Conformational and biological properties of di[delta-(5-nitro-2-pyrimidyl)ornithine 17,18]glucagon. Role of the arginine residues

The Journal of biological chemistry, 1983

Preparation and properties of glucagon analogs prepared by semi-synthesis from CNBr-glucagon

Biochimica et Biophysica Acta (BBA) - General Subjects, 1980

Development of Potent Truncated Glucagon Antagonists

Jung-mo Ahn

Journal of Medicinal Chemistry, 2001

Pure Glucagon Antagonists: Biological Activities and cAMP Accumulation Using Phosphodiesterase Inhibitors

Brian Van Tine, Victor Hruby is to

Peptides, 1997

Biological activities of des-His1[Glu9]glucagon amide, a glucagon antagonist

Cecilia Unson

Peptides, 1989

The essential role of the imidazole group of glucagon in its biological function

Archives of Biochemistry and Biophysics, 1973

Comparative Effects of the Endogenous Agonist Glucagon-Like Peptide-1 (GLP-1)-(7-36) Amide and the Small-Molecule Ago-Allosteric Agent "Compound 2" at the GLP-1 Receptor

Gary Willars

Journal of Pharmacology and Experimental Therapeutics, 2010

Fluorescent glucagon derivatives. I. Synthesis and characterisation of fluorescent glucagon derivatives

mi im

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1988

Conformational and biological properties of a covalently linked dimer of glucagon. Reaction of mono- and bifunctional sulfenyl halides

Biochimica et biophysica acta, 1976

The glucagon receptor of rat liver plasma membrane can couple to adenylate cyclase without activating it

Robin Hesketh

Biochimica Et Biophysica Acta-biomembranes, 1976

A Novel Glucagon Receptor Antagonist Inhibits Glucagon-Mediated Biological Effects

Mari Candelore

Diabetes, 2004

N-Ethylmaleimide uncouples the glucagon receptor from the regulatory component of adenylyl cyclase

Kenneth Lipson

Biochemistry, 1986