A mathematical model describing cellular division with a proliferating phase duration depending on the maturity of cells (original) (raw)
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Model of Cellular Proliferation
2013
We analyse the asymptotic behaviour of a nonlinear mathematical model of cellular proliferation which describes the production of blood cells in the bone marrow. This model takes the form of a system of two maturity structured partial differential equations, with a retardation of the maturation variable and a time delay depending on this maturity. We show that the stability of this system depends strongly on the behaviour of the immature cells population. We obtain conditions for the global stability and the instability of the trivial solution.
A model of proliferating cell populations with inherited cycle length
Journal of Mathematical Biology, 1986
A mathematical model of cell population growth introduced by J. L. Le~owitz and S. I. Rubinow is analyzed. Individual cells are distinguished by age and cell cycle length. The cell cycle length is viewed as an inherited property determined at birth. The density of the population satisfies a first order linear partial differential equation with initial and boundary conditions. The boundary condition models the 15rocess of cell division of mother cells and the inheritance of cycle length by daughter cells. The mathematical analysis of the model employs the theory of operator semigroups and the spectral theory of linear operators. It is proved that the solutions exhibit the property of asynchronous exponential growth.
On the stability of a maturity structured model of cellular proliferation
2019
We analyse the asymptotic behaviour of a nonlinear mathematical model of cellular proliferation which describes the production of blood cells in the bone marrow. This model takes the form of a system of two maturity structured partial differential equations, with a retardation of the maturation variable and a time delay depending on this maturity. We show that the stability of this system depends strongly on the behaviour of the immature cells population. We obtain conditions for the global stability and the instability of the trivial solution.
On the stability of a nonlinear maturity structured model of cellular proliferation
Discrete and Continuous Dynamical Systems, 2004
We analyse the asymptotic behaviour of a nonlinear mathematical model of cellular proliferation which describes the production of blood cells in the bone marrow. This model takes the form of a system of two maturity structured partial differential equations, with a retardation of the maturation variable and a time delay depending on this maturity. We show that the stability of this system depends strongly on the behaviour of the immature cells population. We obtain conditions for the global stability and the instability of the trivial solution.
Modelling and analysis of time-lags in cell proliferation
1997
In this paper, we present a systematic approach for obtaining qualitatively and quantitatively correct mathematical models of some biological phenomena with time-lags. Features of our approach are the development of a hierarchy of related models and the estimation of parameter values, along with their non-linear biases and standard deviations, for sets of experimental data. We demonstrate our method of solving parameter estimation problems for neutral delay differential equations by analyzing some models of cell growth that incorporate a time-lag in the cell division phase. We show that these models are more consistent with certain reported data than the classic exponential growth model. Although the exponential growth model provides estimates of some of the growth characteristics, such as the population-doubling time, the time-lag growth models can additionally provide estimates of: (i) the fraction of cells that are dividing, (ii) the rate of commitment of cells to cell division, (iii) the initial distribution of cells in the cell cycle, and (iv) the degree of synchronization of cells in the (initial) cell population.
For the model of periodic chronic myelogenous leukemia considered by Pujo-Menjouet, Mackey et al., model consisting of two delay differential equations, the equation for the density of so-called "resting cells" was studied from numerical and qualitative point of view in several works. In this paper we focus on the equation for the density of proliferating cells and study it from a qualitative point of view.
Analele Universitatii "Ovidius" Constanta - Seria Matematica, 2015
For the model of periodic chronic myelogenous leukemia considered by Pujo-Menjouet, Mackey et al., model consisting of two delay differential equations, the equation for the density of so-called “resting cells” was studied from numerical and qualitative point of view in several works. In this paper we focus on the equation for the density of proliferating cells and study it from a qualitative point of view.
Modelling and analysis of time-lags in some basic patterns of cell proliferation
Journal of Mathematical Biology, 1998
In this paper, we present a systematic approach for obtaining qualitatively and quantitatively correct mathematical models of some biological phenomena with time-lags. Features of our approach are the development of a hierarchy of related models and the estimation of parameter values, along with their non-linear biases and standard deviations, for sets of experimental data. We demonstrate our method of solving parameter estimation problems for neutral delay differential equations by analyzing some models of cell growth that incorporate a time-lag in the cell division phase. We show that these models are more consistent with certain reported data than the classic exponential growth model. Although the exponential growth model provides estimates of some of the growth characteristics, such as the population-doubling time, the time-lag growth models can additionally provide estimates of: (i) the fraction of cells that are dividing, (ii) the rate of commitment of cells to cell division, (iii) the initial distribution of cells in the cell cycle, and (iv) the degree of synchronization of cells in the (initial) cell population.
Analysis of Cell Kinetics Using a Cell Division Marker: Mathematical Modeling of Experimental Data
Biophysical Journal, 2003
We consider an age-maturity structured model arising from a blood cell proliferation problem. This model is ''hybrid'', i.e., continuous in time and age but the maturity variable is discrete. This is due to the fact that we include the cell division marker carboxyfluorescein diacetate succinimidyl ester. We use our mathematical analysis in conjunction with experimental data taken from the division analysis of primitive murine bone marrow cells to characterize the maturation/ proliferation process. Cell cycle parameters such as proliferative rate b, cell cycle duration t, apoptosis rate g, and loss rate m can be evaluated from CarboxyFluorescein diacetate Succinimidyl Ester 1 cell tracking experiments. Our results indicate that after three days in vitro, primitive murine bone marrow cells have parameters b ¼ 2.2 day ÿ1 , t ¼ 0.3 day, g ¼ 0.3 day ÿ1 , and m ¼ 0.05 day ÿ1 .
Cell cycle length and long-time behaviour of an age-size model
arXiv: Analysis of PDEs, 2021
We consider an age-size structured cell population model based on the cell cycle length. The model is described by a first order partial differential equation with initial-boundary conditions. Using the theory of semigroups of positive operators we establish new criteria for an asynchronous exponential growth of solutions to such equations. We discuss the question of exponential size growth of cells. We show how to incorporate into our description models with constant increase of size and with target size division. We also present versions of the model when the population is heterogeneous.