American Journal of Phytomedicine and Clinical Therapeutics Antidiabetic Activity of Rotula aquatica Lour Roots in Streptozotocin Induced Diabetic Rats (original) (raw)
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Antidiabetic Activity of Rotula aquatica Lour Roots in Streptozotocin Induced Diabetic Rats
2013
The study was designed to evaluate antidiabetic activity on methanolic extracts of Rotula aquatica Lour roots in Streptozotocin induced diabetic rats. The roots of Rotula aquatica Lour were extracted with methanol and evaluated for their antidiabetic activity in Streptozotocin induced diabetic rats at doses levels of 100, 200 and 400 mg/kg body weight. The lowering of blood sugar levels as well as percent blood glucose reduction were calculated and compared with the standard glibenclamide (0.45 mg/kg b.w.). Preliminary phytochemical screening was also conducted for occurrence of compounds. The oral administration of 400 mg/kg b.w. of methanolic extract of roots of Rotula aquatica showed more significant (P<0.01) decrease in blood glucose levels at 4 and 8 th hrs and highly significant (P<0.001) decrease in blood glucose levels at 8 th hr. The methanolic extracts of Rotula aquatica roots showed good activity at a dose of 400 mg/kg body weight .Phytochemical screening revealed p...
Journal of Pharmacognosy and Phytochemistry, 2017
Three plants from indian origin like aerial parts of Schrebera swietenoides, roots of Barleria montana and aerial parts of Rotula aquatica were extracted with methanol and metanolic extracts were evaluated for antidiabetic activity against streptozotocin induced diabetes for their study. Oral administration of these plant extracts at different dose levels of 100 mg/kg, 200 mg/kg and 400 mg/kg were screened in comparision with the standard drug glibenclimide. Among these plant extracts, extract of Barleria montana at a dose of 400 mg/kg b.w exhibited significant activity within 4th and 8th hour intervals showing a reduction in blood glucose levels are 293.94± 4.63 and 235.04± 2.93 mg/dl. preliminary phytochemical screening also conducted which revealed presence of triterpenes, flavonoids and steroid
Antidiabetic potential of Rourea minor (Gaertn.) root in streptozotocin—induced diabetic rats
The present investigation aims to examine the antihyperglycemic potential of Rourea minor (Gaertn.) root in normal and streptozotocin (STZ) induced diabetic rats. The root of Rourea minor (Gaertn.) was extracted using ethanol and water and tested for acute toxicity by up and down staircase method. The aqueous Rourea minor (Gaertn.) water (RMW) extract and ethanolic Rourea minor (Gaertn.) extract (RME) at 200 and 400 mg/kg bodyweight doses were screened for blood glucose lowering capacity in normal and STZ induced diabetic animals; the blood samples were collected from the retro orbital plexus and analyzed for serum glucose (SG) level. Glibenclamide (GLB) was used as a standard. The oral glucose tolerance test (OGTT) was carried out in normal as well as STZ induced diabetic rats whereas, insulin tolerance test was carried out in diabetic rats. At the end of 15 days treatment, serum triglyceride (STG), total cholesterol (STC) and HDL-cholesterol (HDL-c) were assayed by auto analyzer. The results of acute toxicity showed that the animals had good tolerance to single doses of RME/RMW (as high as 3 g/kg) and were non-lethal. The glucose tolerance test in normal rats showed that treatment of RME, RMW (both 400 mg/kg), RME (200 mg/kg) and GLB (0.5 mg/kg) exhibited significant reduction (p<0.001) in SG level over a period of 120 min of oral administration of root extract. After 15 days of daily oral administration of the extracts to STZ induced diabetic rats, higher dose of RME could reduce hyperglycemia to an extent of maximum 43.14 %. Also the ethanolic extract was more effective in reducing the SG level (OGTT in STZ induced diabetic rats) with improved glucose tolerance compared to an aqueous extract. Both the doses of RME and RMW exhibited significant reduction (P<0.001) in all tested lipid parameters as compared to diabetic control rats and restored them to nearly-normal values.
Evaluation of Medicinal Plants to Defeat Diabetes and Related Complications-Review
Diabetes is one of the major health problems around the globe in recent time, its increasing prevalence and high cost of treatment in the world is a cause of concern and is posing a continuous threat to human health since decades. The number of diabetic patients is expected to increase from 371 million from 2012 to 552 million by 2030, if no urgent action is taken. Uncontrolled hyperglycemia in both type 1 and type 2 diabetes lead to the development of both acute and long term complications. There has been a need and desire for a natural, more effective and economically feasible alternative to synthetic anti-diabetic drugs due to their high cost, side effects and failure in achieving ideal results. Nature gives us an array of tools including medicinal plants to beat diabetes, its complications and the underlying causes that lead to diabetes. In recent years, there has been a resurgence of interest in medicinal plants which are believed to be natural origin for bioactive compounds and antioxidants which attracted a great treaty of attention, to control life threatening disease like diabetes in which oxidative dent has been implicated.Interest in natural products research is strong and can be attributed to several factors, including unmet therapeutic requirements, the remarkable diversity of both chemical structures and biological activities of naturally occurring secondary metabolites and improved techniques to isolate, purify and structurally characterize these active constituents.
Antidiabetic potential of plant natural products: A review
International Journal of Green Pharmacy, 2016
The present review explains the use of natural plant products for therapeutics of diabetes. It is a serious metabolic disorder that imposes multiple effects on human health. Although diabetes is curable, an erratic lifestyle always make panic and causes disease severity if proper medication is not being made available. Several ethnomedicines have been used by local people in form of crude extracts prepared from flowers, fruits, and roots of endemic plant species for cure of diabetes. There is a common usage of herbal parts for preparation of concoctions, syrups, vegetables, juices, green tea, from leaves, and roots for therapeutic purposes. This article explains antidiabetic effects of various plant secondary metabolites such as anthraquinones, flavonoids, secoiridoids, iridoids, flavanones, biophenols, triterpenes, benzoic acid derivatives, isochromans, and phytosterols. Daily meals containing good nutraceuticals such as protein and fiber can replace carbohydrate food that is a mai...
Antidiabetic potential of medicinal plants
Acta poloniae pharmaceutica
It is the fact that diabetes can't be cured and it has never been reported that someone had recovered totally from diabetes. The rapidly increasing incidence of diabetes mellitus is becoming a serious threat to mankind health in all parts of the world. Moreover, during the past few years some of the new bioactive drugs isolated from plants showed antidiabetic activity with more efficacy than oral hypoglycemic agents used in clinical therapy. The traditional medicine performed a good clinical practice and is showing a bright future in the therapy of diabetes mellitus. The present paper reviews natural medicines with their mechanism of action and their pharmacological test results. Many studies have confirmed the benefits of medicinal plants with hypoglycemic effects in the management of diabetes mellitus. The effects of these plants may delay the development of diabetic complications and correct the metabolic abnormalities. WHO has pointed out this prevention of diabetes and its ...
Diabetes mellitus is a metabolic disorder characterized by resistance to the action of insulin, insufficient insulin secretion or both. It is becoming one of the most common diseases of the world. Type II diabetes in young has increased 30 fold over the last 20 years concomitant with an increase in obesity. In diabetes mellitus, besides hyperglycemia, cardiovascular disease (CVD) is a major cause of death in the world and is mainly due to atherosclerosis (hardening of the arteries). The treatment for diabetes mellitus would be a drug that not only controls the glycemic level but also prevents the development of atherosclerosis and other complications of diabetics. New drugs and new drug delivery systems for insulin have also been introduced. The Indian indigenous drugs have great importance both from the professional and economic point of view. A large number of plants have been reported to possess anti-diabetic activity e.g., Aconitum napeilus, Aloe vera, Carum carvi, Cichorium int...
Asian Journal of Pharmaceutical and Clinical Research, 2022
Objective: The purpose of the study is to evaluate the anti-diabetic effect of the ethanolic extract of root of Crataeva magna Lour., on streptozotocin-induced diabetic rats. Methods: Streptozotocin (45 mg/kg) was used to induce the diabetes mellitus in rats. Afterward, the diabetic rats will be divided into four groups Group I rats served as diabetic control rats, Group II rats were induced diabetes and treated with standard drug through oral intragastric tube, Group III and Group IV were treated with ethanolic extract (200 and 400 mg/kg). Glibenclamide as reference was to evaluate the effect of the extract. Results: The administration of extract decreased the fasting blood glucose and body weight as well as increased level of total cholesterol and triglycerides which and decreased and HDL level. SGPT and SGOT level were significantly reduced in treatment group. Blood urea and creatinine were a significant difference in blood urea and creatinine. Conclusion: The extract of C.magna Lour. exhibited significant anti-diabetic activity evident from blood glucose level, body weight, serum cholesterol profile, SGOT, SGPT, serum creatinine, and serum urea level.
A Comprehensive Study of Medicinal Plants with Antidiabetic Properties
Journal of Pharmaceutical Research International
The purpose of this research is to assess the anti-diabetic effects of several medicinal herbs. Herbal medicine has grown in popularity in both developing and developed countries over the last several years, owing to its natural origins and lack of negative effects. Even though medicinal plants have been utilized to treat diabetes mellitus from ancient times, they have been offered as abundant but untapped prospective sources for anti-diabetic medicines. It's a reality that diabetes can't be cured, and no one has ever claimed to be completely free of the disease. Diabetes mellitus is becoming a severe hazard to human health in all regions of the world due to its fast growing occurrence. Furthermore, several novel bioactive compounds derived from plants have demonstrated antidiabetic action with greater efficacy than oral hypoglycemic medicines already utilized in clinical therapy in recent years. Despite the fact that many plants are recommended, further pharmacological and ...