ChemInform Abstract: A Novel System for the Synthesis of 2-Aminobenzthiazoles Using Sodium Dichloroiodate (original) (raw)
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Caspian Journal of Environmental Sciences, 2024
This work involved two parts: the first part included synthesis of new Schiff bases from condensation of 2-aminobenzothiazole with different aldehydes in acidic medium, while and the second part included the synthesis of Oxazolidinones from reaction of the prepared Schiff bases with glycine to produce new heterocyclic. Compounds. The structure of prepared compounds were characterized by 1H-NMR, FT-IR techniques and their biological activity was assessed.
Synthesis and Pharmacological Evaluation of 6-SUBSTITUTED 2-AMINOBENZOTHIAZOLES
International research journal of pharmacy, 2018
Heterocyclic compounds and analogues have attracted strong interest due to their biological and pharmacological properties. Nitrogen containing heterocyclics, Benzothiazoles are an important class of heterocyclic compounds and the nucleus containing compounds involved in research aimed at evaluating new products that possess biological activities such as antibacterial, antifungal, anthelmintic, antidiabetic, and anticancer agents. In the present study various derivatives of 6-substituted 2-aminobenzothiazoles were prepared and evaluated for their antibacterial, antifungal, antioxidant and cytotoxic activity by various standard methods. Among the synthesized compounds, most of the compounds exhibited potent activity when compared with that of the standard drugs. Hence the versatile synthetic applicability and biological activity of these heterocyclic compounds will help the chemist to plan, organize and implement new approaches towards discovery of novel derivatives of Benzothiazoles.
1,2,3-Dithiazole Chemistry in Heterocyclic Synthesis
ChemInform, 2007
The chemistry of various 5H-1,2,3-dithiazoles is investigated with emphasis on assisted ring opening and ring closure reactions leading to new heterocycles. Thus on treatment with catalytic tetraalkylammonium iodide N-(2-chloropyrid-3-yl)-and N-(4-chloropyrid-3-yl)-4-chloro-1,2,3dithiazol-5H-imines 19 and 20 give thiazolo [5,4-b]pyridine-2-carbonitrile 16 and thiazolo-[4,5-c]pyridine-2-carbonitrile 17 respectively. Similar treatment of bisdithiazoles 29 and 30 afford high yielding routes to 1,3,4-thiadiazole-2,5-dicarbonitrile 31 and thiazole-2,4,5tricarbonitrile 32 respectively. N-(Pyrid-3-yl)-4-chloro-1,2,3-dithiazol-5H-imine 36 reacts with secondary alkylamines to give as main product pyrido[2,3-d]pyrimidines 37 and several minor byproducts including a deep green quinoidal 2,2'-bithiazole 40. Dithiazolylidenacetonitriles 43 react with either anhydrous HBr or tetraalkylammonium chloride to afford a series of 3-halo-4substituted-isothiazole-5-carbonitriles 45 and 52 respectively. The reactions of dithiazoles 43 with tetraalkylammonium chloride are complicated owing to the formation of isothiazolopentathiepin-8-carbonitrile 53, isothiazolodithiin-4,5,7-tricarbonitrile 54, tetracyanothiophene 56 and an unidentified compound 55 whose possible structures are proposed. The mechanistic rationales for the formation of the identified products are proposed.
This research including preparation new derivatives for heterocyclic compounds are (1,3 benzothiazole), (1,3oxazpine) ,and(imidazolidin-4-one). The process synthesis in us research divided into two major pathways.: First , synthesis 2-amino benzothiazole derivatives [ 6-acetyle-2-amino benzothiazole (A1)and [6,'6]biphenyl thiazolyle [2,2']di amine (B1) ] from p-amino acetophenone and benzidine respectively .Second pathway , with some aldehydes subsisted ,amin group of benzothiazole reacted to form Schiff's base compounds that enter reaction with phathlic anhydride to produced (1,3 Oxazpine) derivatives (As3,As4,B3), and with (valine) amino acid to form imidazolidin-4-one heterocyclic (As5).The reactions followed up by using Thin Layer Chromatographic method (TLC) to perform the reaction ,as well as, characterizing new derivatives by using FT-IR and (C.H.N.S) measurements for these compounds.