Orthokeratinized Odontogenic Cyst (original) (raw)
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Histopathological Examination and Literature Review of Orthokeratinized Odontogenic Cyst
Open Journal of Stomatology, 2019
Background: With transitions in the disease concept of orthokeratinized odontogenic cyst (OOC), the pathogenesis and etiology have not been sufficiently elucidated. Objectives: OOC cases were reclassified and observed to understand the clinico-histopathological characteristics. In addition, literature review of OOC was performed to better organize the pathology. Materials and methods: Subjects with jawbone cysts lined by keratinized stratified squamous epithelium from 2005 to 2018 were reclassified, and clinico-histopathological findings were analyzed. Previous reports of OOC/orthokeratinized-type odontogenic keratocyst (OKC) from 1980 to 2019 were organized. Results: Five cases of OOC were diagnosed, representing 2.1% of odontogenic developmental cysts (total, 239 cases). Mean age was 37.6 years, with a female predominance. The mandibular molar area was the frequent site, and all cysts were solitary. Sixty percent involved an impacted tooth. Mean maximum diameter of the cyst was 2.2 cm. Histopathologically, 4 cases were unilocular, and partial palisading of the basal layer and scattered epithelial islands were observed in 2 cases each and formation of daughter cysts was noted in 3 cases. Previous papers described that most were unilocular and related to impacted teeth. Mean age ranged between 20 and 40 years, and the mandibular molar region was dominant. Recurrence rates were low. Conclusion: OOC shows a different biological attitude to OKC and is closer to dentigerous cyst. Meanwhile, OOC shows a similar histology of epidermoid cysts accompanying the granular layer. We thus surmised that OCC represents an independent concept as an odontogenic developmental cyst.
Orthokeratinized Odontogenic Cyst: A Case Report- A Milder Variant of OKC or an Independent Entity
https://www.ijhsr.org/IJHSR\_Vol.7\_Issue.9\_Sep2017/IJHSR\_Abstract.049.html, 2017
Orthokeratinized odontogenic cyst (OOC) is a relatively uncommon developmental cyst, thought to be arising from the cell rests of the dental lamina. Orthokeratinized odontogenic cyst (OOC) was first described by Schultz in 1927 and in 1945 Philipsen considered it to be a variant of Odontogenic keratocyst (OKC). OOC exhibits distinctive clinical, pathologic, and behavioral features that varied substantially from KCOT and hence now it is considered as a separate entity. We present a rare case of OOC occurring in a female patient which was attached to the lateral aspect of the root apex of the impacted third molar giving a false gross and radiographic appearance of lateral variant of dentigerous cyst.. The clinical, radiological, and histopathological features of this cyst and its surgical management are discussed.
Journal of Oral and Maxillofacial Pathology
Orthokeratinized odontogenic cyst (OOC) is an uncommon odontogenic cyst. It has been categorized as a subtype of odontogenic keratocyst (OKC). In 2005, it was classified as a distinct entity. OOC should be histopathologically differentiated from OKC, which has a higher recurrence rate and lower malignant potential. In addition, OOC should be examined for malignant transformation. The epithelium of odontogenic cysts may rarely show malignant transformation. However, malignant transformation has been reported in inflammatory cysts such as the residual cyst and periapical cyst. The number of carcinomas arising from an OOC is low. This paper describes eight cases of OOC; out of which, two showed the development of squamous cell carcinoma from their epithelial lining.
Orthokeratinized Odontogenic Cyst: Case Report
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2017
Orthokeratinized odontogenic cyst (OOC) is a relatively uncommon developmental cyst, thought to be arising from the cell rests of the dental lamina. Orthokeratinized odontogenic cyst (OOC) was first described by Schultz in 1927 and in 1945 Philipsen considered it to be a variant of Odontogenic keratocyst (OKC). OOC exhibits distinctive clinical, pathologic, and behavioral features that varied substantially from KCOT and hence now it is considered as a separate entity. We present a rare case of OOC occurring in a female patient which was attached to the lateral aspect of the root apex of the impacted third molar giving a false gross and radiographic appearance of lateral variant of dentigerous cyst.. The clinical, radiological, and histopathological features of this cyst and its surgical management are discussed.
Bilateral orthokeratinized odontogenic cyst: A rare case report and review
Journal of Oral and Maxillofacial Pathology, 2014
Orthokeratinized odontogenic cyst (OOC) is a developmental cyst of jaw and was initially considered by the World Health Organization (1992) as the uncommon orthokeratinized variant of odontogenic keratocyst (OKC). However, studies have shown that OOC has peculiar clinicopathologic aspects when compared with other developmental odontogenic cysts, especially OKC. So orthokeratinized odontogenic cyst now stands out to be a distinct entity. Clinically, it occurs as a single cyst, shows a predilection for males and is most often found in the second to the fifth decade. Its bilateral occurrence is extremely rare. The purpose of the article is to present a rare case of bilateral OOC arising in the mandible and review the literature on bilateral occurrence of this lesion.
Orthokeratinized odontogenic cyst : case report of two cases with review of literature
2017
An orthokeratinized odontogenic cyst (OOC) is a rare developmental jaw cyst, that has been considered as a variant of the keratocystic odontogenic tumour (KCOT), which was irst described in 1927 by Schultz. We, report two cases of OOC along with review of literature. Of the two cases, the irst one was noted in a 31 year old female, while the second one was seen in 48 year old male, both affecting the right posterior region of the mandible. Since, OOC has a less aggressive nature & no propensity to recur a conservative management with complete enucleation of the cystic lesion seems to be the treatment of choice compared to KCOT, where the ideal treatment involves more radical approach, through peripheral osteotomy, chemical curettage or block resection. Hence, now it has become essential to identify OOC as a distinct entity, as it is an odontogenic cyst with varied biological behaviour.
An Aggressive Orthokeratinized Odontogenic Cyst of the Mandible: A Case Report
IOSR Journal of Dental and Medical Sciences, 2013
Orthokeratinized odontogenic cyst (OOC) is a developmental cyst that occurs in the jaw. it was initially defined by the world health organization as the orthokeratinized variant of odontogenic keratocyst (OKC). However, studies have shown that OOC has a peculiar clinicopathologic aspects when compared with other developmental odontogenic cysts, especially OKC's. The orthokeratinized odontogenic cyst is a distinct clinicopathologic entity and is histologically characterized by a thin, uniform, epithelial lining with orthokeratinization. Clinically, the orthokeratinized cyst is a single cyst, shows a predilection for males, and is most often found in the second to the fifth decade. It is not a dentigerous cyst but is often mistaken for a dentigerous cyst because of its association with unerrupted or impacted tooth in the posterior mandible. It exhibits lower clinical aggressiveness compared to its counterpart OKC. The purpose of the article is to present a case of large aggressive OOC in the anterior mandible and to highlight the importance of, distinguishing it from the more commonly occurring OKC or keratocystic odontogenic tumour (KCOT).
An unusually extensive orthokeratinized odontogenic cyst: A case report
IP Journal of Diagnostic Pathology and Oncology
While odontogenic keratocysts (OKC) are fairly common and well-known, orthokeratinized odontogenic cysts (OOCs) are quite rare accounting for less than 1% of odontogenic cysts. The entity is characterized by the presence of a predominant orthokeratinized lining. OOC is much less aggressive as compared to OKC and simple enucleation is discerned as adequate treatment with minimal chances of recurrence. The present case report describes an extensive OOC that involved most of the angle and ramus of the mandible in a 25-year-old female.
Ortho keratinized Odontogenic Cyst of Mandible: A Rare Case Report
Shahid Beheshti University Dental Journal, 2015
Objective: The Ortho keratinized Odontogenic Cyst (OOC) is a rare lesion originates from dental lamina and clinically, it may be mistaken for many other odontogenic cysts and Tumors. Microscopically, It should be distinguished from KCOT because of differences in biologic behavior and histologic features. Case: An interesting case of OOC arising in the edentulous mandibular right first premolar region of a 55-year-old woman is reported. Under the initial clinical diagnosis of a residual cyst, the excisional biopsy was performed. Because of detection of an orthokeratinized epithelium lining, a definite diagnosis of OOC was made. Conclusion: Microscopic examination is crucial for making the correct diagnosis of such lesions, therefore establishing patients' prognosis accurately.
Odontogenic Cyst of the Mandible: A Case Report
2012
Orthokeratinized odontogenic cyst (OOC) is a developmental cyst that occurs in the maxilla and the mandible and was initially defined by the World Health Organization as the uncommon orthokeratinized type of odontogenic keratocyst (OKC). However, studies have shown that OOC has peculiar clinicopathologic aspects when compared with other developmental odontogenic cysts, especially OKCs. The orthokeratinized odontogenic cyst is a distinct clinicopathologic entity and is histologically characterized by a thin, uniform, epithelial lining with orthokeratinization and a subjacent granular cell layer. The basal cells are usually cuboidal or flattened. Clinically, the orthokeratinized cyst is a single cyst, shows a predilection for males, and is most often found in the second to the fifth decade. It is not dentigerous cyst but is often mistaken for a dentigerous cyst in the posterior mandible and exhibits little clinical aggressiveness. The purpose of the article is to present a case of OOC...