Plasma Treatment of Biomedical Materials (original) (raw)
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I. JUNKAR et al.: PLASMA TREATMENT OF BIOMEDICAL MATERIALS PLASMA TREATMENT OF BIOMEDICAL MATERIALS
2016
Surface plasma treatment techniques for modification of biomedical polymeric materials are presented. The emphasis is on the use of non-equilibrium radiofrequency (RF) oxygen and nitrogen plasma. By variation of discharge parameters (power, discharge frequency, type of gas) and plasma parameters (density of neutrals and ions, kinetic energy of electrons, gas temperature) it is possible to produce polymer surfaces with different surface properties. Already after short plasma treatment time the surface of polymeric material becomes hydrophilic. Formation of nitrogen and oxygen functional groups is observed immediately after plasma treatment. By optimisation of plasma treatment time the number of newly formed functional groups can be increased. Plasma treatment also produces morphological changes of the surface; nanohills of different shapes and height can be formed on PET surface depending on the treatment time and type of gas. Evidently the change in surface morphology affects the ch...
Plasma surface modification of polymers for biomedical use
Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2003
Polymeric materials can be used in many application areas due to their mechanical (e.g. elastic) characteristics, chemical stability, and their light weight, as well as for their many design possibilities. Even in the fields of medicine and biotechnology many products are completely or partly made of polymers. In contact with biological systems, compatibility of these materials is not always given. To fulfill the requirements for medical applications, the surfaces have to be modified. Plasma techniques are demonstrated as an appropriate tool for the generation of the demanded surface properties. Experimental data are given for surface modification by plasma polymerization, with retention of the functional groups of the monomers used. Qualitative and quantitative characterization of the thin films with respect to the type and density of available groups at the surfaces is presented. Some possible applications of plasma-modified polymers are also discussed.
Plasma Assisted Surface Modification Processes for Biomedical Materials and Devices
This contribution reviews cold plasma processes that are investigated and utilized in academic and technological fields related to Life Sciences, in particular for tailoring surface composition and morphology of materials of different utilization in Medicine and Biology for implants, prostheses, biosensors, devices and scaffolds for tissue engineering. The final goal of the research in this field is, in general, to achieve the capability of driving at will the behaviour (adhesion, growth, morphology, physiology, etc.) of cells and biological tissues in vitro and in vivo at the surface of modified materials. Recent advances on different plasma-processes for biomedical applications, developed in radiofrequency (RF, 13.56 MHz) Glow Discharges at the group of the authors are reported in this review, including: the synthesis of functional surfaces for direct cell growth and biomolecule immobilization; the deposition of non-fouling coatings; the deposition of nano-composite bacterial resi...
The Influence of Plasma Composition on the Properties of Plasma Treated Biomaterials
MRS Proceedings, 2001
ABSTRACTThe response of a biological environment when in contact with an artificial material is primarily determined by the material surface properties such as composition, contact angle and free surface energy [1,2]. Owing to that, different treatments have been employed to improve the performance of biocompatible materials. In this sense, plasma-based techniques are very attractive because they enable the surface processing of materials with virtually any geometry preserving bulk properties. Furthermore, other characteristics make plasma treatment of particular interest in biomaterial processing. Those characteristics include, for instance, a) the possibility of using a large number of different chemicals to introduce any desired functional group on the surface, b) the treatment is performed in an intrinsically sterile environment and, c) different kind of materials (such as ceramics, metals and polymers) including those chemically inert can be treated.
Plasma-surface modification of biomaterials
Plasma-surface modification (PSM) is an effective and economical surface treatment technique for many materials and of growing interests in biomedical engineering. This article reviews the various common plasma techniques and experimental methods as applied to biomedical materials research, such as plasma sputtering and etching, plasma implantation, plasma deposition, plasma polymerization, laser plasma deposition, plasma spraying, and so on. The unique advantage of plasma modification is that the surface properties and biocompatibility can be enhanced selectively while the bulk attributes of the materials remain unchanged. Existing materials can, thus, be used and needs for new classes of materials may be obviated thereby shortening the time to develop novel and better biomedical devices. Recent work has spurred a number of very interesting applications in the biomedical field. This review article concentrates upon the current status of these techniques, new applications, and achievements pertaining to biomedical materials research. Examples described include hard tissue replacements, blood contacting prostheses, ophthalmic devices, and other products. #
Surface Modification of Polymeric Materials by Plasma Treatment
Materials Research, 2002
Low-temperature plasma treatment has been used in the last years as a useful tool to modify the surface properties of different materials, in special of polymers. In the present work low temperature plasma was used to treat the surface of asymmetric porous substrates of polysulfone (PSf) membranes. The main purpose of this work was to study the influence of the exposure time and the power supplied to argon plasma on the permeability properties of the membranes. Three rf power levels, respectively 5, 10 and 15 W were used. Treatment time ranged from 1 to 50 min. Reduction of single gas permeability was observed with Ar plasma treatments at low energy bombardment (5 W) and short exposure time (20 min). Higher power and/or higher plasma exposition time causes a degradation process begins. The chemical and structural characterization of the membranes before and after the surface modification was done by AFM, SEM and XPS.
Shinku, 2007
Surface modiˆcation using plasma treated and graft polymerization is versatile process, with systems on the market capable of treating everything from polymer, metal, and ceramic substrates. The major advantage is that the modiˆcation is caused no substrate damage or bulk property changes. This is a very eŠective method to modify the surfaces of biomaterials to achieve desired physical or mechanical properties, or to induce a speciˆc response when the device is placed in the body. They oŠer attractive possibilities for developing new biomaterials and for improving the performance of existing materials and devices. Hence, in this review, we describe the application of plasma treatment and graft polymerization on biomaterialsˆeld. The various applications are discussed in the following: (1) easy stripped-oŠ wound dressing, (2) porous three-dimensional temporary scaŠolds, (3) quartz crystal microbalance (QCM) base biosensors, and (4) covalent immobilization of glucose oxidase onto inorganic substrates
Plasma Modification of Biomaterials Controlled by Surface Analysis
Biomaterials are defined as materials to interact or be in contact with biological systems. This paper describes the fumctionalization of soft polymer surfaces against non-specific protein adsorption. A RF plasma changes the chemical composition of a surface within the nm-range, without changing bulk material properties. The chemical control of the surface is assured by X-ray Photoelectron Spectroscopy (XPS) and contact angle measurements (CAM). NH 3 -H 2 treated Polystyrene (PS) chips are used for enhanced biological-immobilization for sensors. Such biosensors use fluorescence immunoassays in medical diagnostics. Pseudomonas aeruginosa is one of the most prevalent bacterial strains in a clinical environment. Teflon-like films deposited on native PVC are used for the preparation of non-fouling surfaces through the physisorption of PEO-PPO-PEO Pluronics ® co-polymers. Secondly, PEO-like and Ag/PEO-like polymers were prepared by plasma polymerization techniques.