Antiinflammatory evaluation of leaves of Plumeria acuminata (original) (raw)
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Anti-inflammatory Activity of an Ornamental Plant Plumeria Obtusa
Advances in Pharmacology and Pharmacy, 2016
Aims: An experiment was conducted to evaluate the anti-inflammatory effects of ethanolic bark extract of Plumeria obtusa. Material and method: Anti-inflammatory activity was evaluated by using two different animal models namely cotton pellet method and carrageenan induce paw edema in male Wistar rats at a dose of 100,200 and 400 mg/kg respectively. Results: Phytochemical examination of the extract exposed the existence of alkaloids, flavonoids, tannins and terpenoids. The ethanolic extract elicited highly significant (p<0.001) inflammatory activity in a dose dependent manner on cotton pellet method and carrageenan induce paw edema method. This was noticed by prominently decrease of paw volume in carrageenan induce paw edema and marked increase in % inhibition of cotton pellet Granuloma pouch at the dose of 100,200 and 400 mg/kg respectively. Conclusion: The present investigations showed that the ethanolic extract Plumeria obtusa stem bark has potential anti-inflammatory activity when screened on carrageenan-induced paw edema and cotton pellet Granuloma pouch models in rats.
BioMed Research International, 2014
Aim. The present investigation was designed to evaluate antiarthritic potential of fractions of hydroalcoholic extract from leaves of P. alba. Materials and Methods. Plumeria alba L. leaves were extracted with hydroalcohol (30 : 70) to obtain hydroalcoholic extract of P. alba. This extract was further fractionated with solvents ethyl acetate and n-butanol to obtain EAPA and BPA, respectively. These fractions were tested against formaldehyde and Freund's complete adjuvant (FCA) induced arthritis. Arthritis assessment, paw volume, body weight, motor incoordination, and nociceptive threshold were measured. On day 21, the animals were sacrificed and histopathology was done. Results. The 100 and 200 mg/kg doses of EAPA and BPA caused a significant ( ≤ 0.05-0.01) reduction in paw swelling in both models. Erythrocyte sedimentation rate (ESR) and spleen weight decreased significantly ( < 0.01) in arthritic rats treated with extracts. There was significant ( < 0.05) improvement in thymus weight in EAPA treated rats whereas significant ( < 0.01) improvement was also seen in haemoglobin level (Hb) in diclofenac treated group. Motor incoordination and nociceptive threshold were also significantly ( ≤ 0.05-0.01) improved. Conclusion. The present study suggests that Plumeria alba L. has protective activity against arthritis and supports the traditional use of P. alba for rheumatism and other inflammatory diseases.
Pharmaceutical and Biological Evaluations, 2018
Objective: Plumeria rubra is an important traditional medicinal plant used in various ailments and the indigenous plant as a medicament for treatment of various inflammatory conditions is well documented in literature. The analgesic activity was evaluated by hot-plate and acetic acid induced writhing methods.Methods: The leaves of P. rubra were collected from the local area in and around Palakkad, Kerala (India). About 1500 g of the powder was extracted using Soxhlet apparatus for 12 h using 5.0 L of Ethanol as solvent. The test extracts was administered intraperitoneally at a dose of 100 and 200 mg/kg while Pentazocine (5 mg/kg) and diclofenac sodium (10 mg/kg) served as standards.Results: The ethanolic extract of 200 mg/kg having significant analgesic activity in Acetic acid induced abdominal writhing response and percentage of inhibition (PI) (p<0.01 )when compared to control.. The Ethanolic extract of 100 mg/kg and 200 mg/kg exhibited significant analgesic activity in the hot...
Phytochemical and Pharmacological activity of Genus Plumeria: An updated review *Correspondence Info
Genus Plumeria (Apocynaceae) contain largely of shrubs or flowering trees which are grown throughout the tropical region including many parts of India. These plants are well known for their religious value, cosmetic importance and tremendous potential to be used as medicinal agents to cure infections, digestive diseases, anti-inflammatory and antipyretic action, anti-tumor potential, anti-oxidant properties etc. In this review article various established facts regarding species of Plumeria have been compiled. The article highlights the historical findings and present medicinal status of these plants with their potential to be used in the field of drug development in future.
Phytochemical and Pharmacological activity of Genus Plumeria: An updated review
Genus Plumeria (Apocynaceae) contain largely of shrubs or flowering trees which are grown throughout the tropical region including many parts of India. These plants are well known for their religious value, cosmetic importance and tremendous potential to be used as medicinal agents to cure infections, digestive diseases, anti-inflammatory and antipyretic action, anti-tumor potential, anti-oxidant properties etc. In this review article various established facts regarding species of Plumeria have been compiled. The article highlights the historical findings and present medicinal status of these plants with their potential to be used in the field of drug development in future.
Asian Journal of Pharmaceutical and Clinical Research, 2021
Objective: Plumeria alba (Apocynaceae), commonly known as “Frangipani” is an important medicinal plant, widely distributed throughout Southern India. In the traditional medicinal system, different parts of this plant have been mentioned to be useful in a wide variety of diseases. In this study, analgesic activity of aqueous and alcoholic extract of flowers of P. alba Linn was evaluated by hot-plate and acetic acid-induced writhing methods to substantiate and expand its clinical applications. Methods: The flowers of P. alba were collected from the local area in and around Coimbatore (India). The flowers were dried, powdered, and were extracted using soxhlet apparatus for 12 h using water and 95% of ethanol as a solvent. The test extracts were administered orally at a dose of 100 & 200 mg/kg while diclofenac sodium (10 mg/kg) served as standard. Results: The ethanolic flower extract of 200 mg/kg had significant analgesic activity in acetic acid-induced abdominal writhing response (***...
An Review of Phytochemical Constituents & Pharmacological Activity of Plumeria Species
In Indian system of medicine, a large number of drugs of either herbal or mineral origin have been advocated for various types of diseases, India has been one of the pioneers in the development and practice of well-documented indigenous systems of medicine, particularly Ayurveda, Siddha and Unani. For millennia, the Indian population has depended mainly upon plant based crude drugs for a variety of ailments. This alternative system of medicine is gaining increasing popularity worldwidePlumeria species are widely used as a purgative, remedy for diarrhea,cure of itch, bronchitis, cough,asthma, fever bleeding piles, dysentery, blood disorders and tumors etc. .This review on plumeria species focuses over the plant chemical compositions, its ethnomedicinal uses, linked from ancient times to the present with a scope of development in future.
Phytochemical analysis and antimicrobial activity from different parts of Plumeria alba
2010
A local herb, Kacip Fatimah, is famous amongst Malay women for its uses in parturition; however, its phytochemical contents have not been fully documented. Therefore, a study was performed to evaluate the phenolics, flavonoids, and total saponin contents, and antibacterial and antifungal properties of the leaf, stem and root of three varieties of Labisia pumila Benth. Total saponins were found to be higher in the leaves of all three varieties, compared to the roots and stems. Leaves of var. pumila exhibited significantly higher total saponin content than var. alata and lanceolata, with values of 56.4, 43.6 and 42.3 mg diosgenin equivalent/g dry weight, respectively. HPLC analyses of phenolics and flavonoids in all three varieties revealed the presence of gallic acid, caffeic acid, rutin, and myricetin in all plant parts. Higher levels of flavonoids (rutin, quercitin, kaempferol) were observed in var. pumila compared with alata and lanceolata, whereas higher accumulation of phenolics (gallic acid, pyrogallol) was recorded in var. alata, followed by pumila and lanceolata. Antibacterial activities of leaf, stem and root extracts of all varieties determined against both Gram positive (Micrococcus luteus, Bacillus subtilis B145, Bacillus cereus B43, Staphylococcus aureus S1431) and Gram negative (Enterobacter aerogenes, Klebsiella pneumonia K36, Escherichia coli E256, Pseudomonas aeruginosa PI96) pathogens showed that crude methanolic extracts are active against these bacteria at low concentrations, albeit with lower antibacterial activity compared to
June , 2023
Abstract Background and Objective: Plumeria acuminata has a long history of use in traditional medicine which includes treatment of rheumatism, pruritic skin lesion, toothache, asthma, cracks on the feet sole crack, heart stroke, dysentery and diarrhoea. This study was designed to extract essential oils from the leaf, flower and root of P. acuminata, analyse the oils and evaluate their cytotoxicity and antimicrobial and antioxidant activities. Materials and Methods: Essential oils obtained from leaf, flower and root of P. acuminata by hydrodistillation were analyzed using the Gas Chromatography-Mass Spectrometry technique. The toxicity, antimicrobial and antioxidant activities of the oils were evaluated via brine shrimp lethality, agar well-diffusion and DPPH free radical-scavenging assays, respectively. Results: A total of 26, 85 and 12 constituents were identified in the leaf, flower and root oils corresponding to 70.0, 99.8 and 97.4% of the whole oils, respectively. The major components were $-eudesmol, 43.0% (root), nonanal, 20.0% (flower), palmitic acid, 27.6% (root) and linalool, 16.1% (leaf). The oils exhibited high toxicity with LC50 less than 100 ppm, indicating they are biologically active. They also showed potent antimicrobial activities with an inhibition zone range of 1.7±0.2-22.1±0.1 mm when compared with the activities of standard drugs: Gentamycin (8.0±0.0-12.5±0.1 mm) and ketoconazole (10.3±0.4-21.0±1.4 mm). However, low antioxidant activities were demonstrated by the oils (IC50 = 441-695 µg mLG1 ) concerning the positive control, "-tocopherol (81.58 µg mLG1 ) and butylated hydroxyanisole (45.11 µg mLG1 ). Conclusion: The findings from this study suggest that P. acuminata essential oils are biologically active and could be natural sources of antibiotics.