Evaluation of analgesic activity of ethanolic and aqueous extracts of leaf of Plumeria rubra in albino rat (original) (raw)
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Asian Journal of Pharmaceutical and Clinical Research, 2021
Objective: Plumeria alba (Apocynaceae), commonly known as “Frangipani” is an important medicinal plant, widely distributed throughout Southern India. In the traditional medicinal system, different parts of this plant have been mentioned to be useful in a wide variety of diseases. In this study, analgesic activity of aqueous and alcoholic extract of flowers of P. alba Linn was evaluated by hot-plate and acetic acid-induced writhing methods to substantiate and expand its clinical applications. Methods: The flowers of P. alba were collected from the local area in and around Coimbatore (India). The flowers were dried, powdered, and were extracted using soxhlet apparatus for 12 h using water and 95% of ethanol as a solvent. The test extracts were administered orally at a dose of 100 & 200 mg/kg while diclofenac sodium (10 mg/kg) served as standard. Results: The ethanolic flower extract of 200 mg/kg had significant analgesic activity in acetic acid-induced abdominal writhing response (***...
British Biomedical Bulletin, 2014
Shade dried flowers of Plumeria rubra f. rubra and Plumeria rubra f. lutea were subjected to successive solvent extraction by soxhlation using n-hexane, chloroform, ethyl acetate and methanol. The extracts were subjected to preliminary phytochemical screening using standard procedures and the data obtained from the flowers of both the species was comparatively evaluated. The methanolic extracts, rich in phytochemical constituents, were screened for analgesic activity (acetic acidinduced writhing & tail immersion methods) using diclofenac (10mg/kg b.w) as standard and antipyretic activity (brewer’s yeast-induced pyrexia test) using paracetamol (100mg/kg; p.o.) as standard at dose levels of 250 and 500 mg/kg b.w. Oral administration of methanolic extracts of Plumeria rubra f. rubra and Plumeria rubra f. lutea (MEPR & MEPL) produced significant reduction in number of writhes induced by acetic-acid. Moreover, in tail immersion, MEPR & MEPL significantly raised the pain threshold at different time intervals, in comparison with control. There was a significant dose-dependent inhibition in both the methods. In antipyretic activity, MEPR & MEPL significantly reduced hyperthermia at either dose levels. The results obtained in all the animal models were highly significant and comparable to that of standard drugs. Hence, from the above findings, it can be concluded that Plumeria rubra possesses potent analgesic and moderate antipyretic properties. However the methanolic extract of flowers of Plumeria rubra f. rubra was found to be more potent than that of Plumeria rubra f. lutea flower extract.
Antiinflammatory evaluation of leaves of Plumeria acuminata
BMC Complementary and Alternative Medicine
[corrected] Plumeria acuminata belonging to the family Apocynaceae is commonly known as 'perungalli' in Tamil and is widely distributed throughout the Southern parts of India. In traditional medicinal system different parts of the plant have been mentioned to be useful in a variety of diseases. The plant material is widely used as a purgative, remedy for diarrhoea and cure for itch. The milky juice is employed for the treatment of inflammation and rheumatism. The bark has been reported to be useful in hard tumors, diarrhoea and gonorrhoea. The objective of the present study was to evaluate the antiinflammatory activity of methanol extract of leaves of Plumeria acuminata on carrageenan, dextran, histamine and serotonin-induced inflammation in rat hind paw oedema models. Acute and chronic inflammation models were used to evaluate the anti-inflammatory activity of the extract. Wistar albino rats of either sex weighing 180-200 g were used. In acute model carrageenan, dextran, hi...
An Review of Phytochemical Constituents & Pharmacological Activity of Plumeria Species
In Indian system of medicine, a large number of drugs of either herbal or mineral origin have been advocated for various types of diseases, India has been one of the pioneers in the development and practice of well-documented indigenous systems of medicine, particularly Ayurveda, Siddha and Unani. For millennia, the Indian population has depended mainly upon plant based crude drugs for a variety of ailments. This alternative system of medicine is gaining increasing popularity worldwidePlumeria species are widely used as a purgative, remedy for diarrhea,cure of itch, bronchitis, cough,asthma, fever bleeding piles, dysentery, blood disorders and tumors etc. .This review on plumeria species focuses over the plant chemical compositions, its ethnomedicinal uses, linked from ancient times to the present with a scope of development in future.
Phytochemical and Pharmacological activity of Genus Plumeria: An updated review
Genus Plumeria (Apocynaceae) contain largely of shrubs or flowering trees which are grown throughout the tropical region including many parts of India. These plants are well known for their religious value, cosmetic importance and tremendous potential to be used as medicinal agents to cure infections, digestive diseases, anti-inflammatory and antipyretic action, anti-tumor potential, anti-oxidant properties etc. In this review article various established facts regarding species of Plumeria have been compiled. The article highlights the historical findings and present medicinal status of these plants with their potential to be used in the field of drug development in future.
Phytochemical and Pharmacological activity of Genus Plumeria: An updated review *Correspondence Info
Genus Plumeria (Apocynaceae) contain largely of shrubs or flowering trees which are grown throughout the tropical region including many parts of India. These plants are well known for their religious value, cosmetic importance and tremendous potential to be used as medicinal agents to cure infections, digestive diseases, anti-inflammatory and antipyretic action, anti-tumor potential, anti-oxidant properties etc. In this review article various established facts regarding species of Plumeria have been compiled. The article highlights the historical findings and present medicinal status of these plants with their potential to be used in the field of drug development in future.
Anti-inflammatory Activity of an Ornamental Plant Plumeria Obtusa
Advances in Pharmacology and Pharmacy, 2016
Aims: An experiment was conducted to evaluate the anti-inflammatory effects of ethanolic bark extract of Plumeria obtusa. Material and method: Anti-inflammatory activity was evaluated by using two different animal models namely cotton pellet method and carrageenan induce paw edema in male Wistar rats at a dose of 100,200 and 400 mg/kg respectively. Results: Phytochemical examination of the extract exposed the existence of alkaloids, flavonoids, tannins and terpenoids. The ethanolic extract elicited highly significant (p<0.001) inflammatory activity in a dose dependent manner on cotton pellet method and carrageenan induce paw edema method. This was noticed by prominently decrease of paw volume in carrageenan induce paw edema and marked increase in % inhibition of cotton pellet Granuloma pouch at the dose of 100,200 and 400 mg/kg respectively. Conclusion: The present investigations showed that the ethanolic extract Plumeria obtusa stem bark has potential anti-inflammatory activity when screened on carrageenan-induced paw edema and cotton pellet Granuloma pouch models in rats.
BioMed Research International, 2014
Aim. The present investigation was designed to evaluate antiarthritic potential of fractions of hydroalcoholic extract from leaves of P. alba. Materials and Methods. Plumeria alba L. leaves were extracted with hydroalcohol (30 : 70) to obtain hydroalcoholic extract of P. alba. This extract was further fractionated with solvents ethyl acetate and n-butanol to obtain EAPA and BPA, respectively. These fractions were tested against formaldehyde and Freund's complete adjuvant (FCA) induced arthritis. Arthritis assessment, paw volume, body weight, motor incoordination, and nociceptive threshold were measured. On day 21, the animals were sacrificed and histopathology was done. Results. The 100 and 200 mg/kg doses of EAPA and BPA caused a significant ( ≤ 0.05-0.01) reduction in paw swelling in both models. Erythrocyte sedimentation rate (ESR) and spleen weight decreased significantly ( < 0.01) in arthritic rats treated with extracts. There was significant ( < 0.05) improvement in thymus weight in EAPA treated rats whereas significant ( < 0.01) improvement was also seen in haemoglobin level (Hb) in diclofenac treated group. Motor incoordination and nociceptive threshold were also significantly ( ≤ 0.05-0.01) improved. Conclusion. The present study suggests that Plumeria alba L. has protective activity against arthritis and supports the traditional use of P. alba for rheumatism and other inflammatory diseases.
Pharmacognostic and phytochemical studies on Plumeria obtusa L
From last few decades there is an upsurge in the use of herbal medicines all over the world and these herbal drugs should be studied scientifically to develop their monographs to assure their quality. The present research work was an attempt to establish parameters for identification of Plumeria obtusa L. (Fam. Apocynaceae) according to the guidelines of WHO, by studying its morphological and organoleptic characters, detailed microscopic evaluation, histochemical studies, fluorescence analysis, loss on drying, extractive values, swelling index, foaming index and preliminary phytochemical screening of the leaves and flowers. Although conventional, but it is simple, easy and quick way for identification and standardization of herbal substances affordable even in developing countries. This is the first report on pharmacognostic and physicochemical studies on P. obtusa which can be helpful in establishing pharmacopoeial monograph of this plant.
Phytochemical Constituents, Traditional Uses, and Pharmacological Properties of the Genus Plumeria
Chemistry & Biodiversity, 2011
The cytotoxicity of the methanol extract of Origanum syriacum against human cerivical adenocarcinoma, Hela cells, was evaluated by the MTT assay. From the crude extract, a new flavone glycoside, acacetin-7-O-[2-O-α-L-rhamnopyranosyl-6-O-β-D-glucopyranosyl]-β-D-glucopyranoside (1), together with the ten known flavonoids luteolin (2), apigenin (3), luteolin-6-C-glucoside (4), luteolin-3-methylether-6-C-glucoside (5), luteolin-7,4-dimethyether-6-C-glucoside (6), apigenin-7methylether-6-C-glucoside (7), apigenin-7-O-glucoside (8), diosmetin-7-O-glucoside (9), acacetin-7-O-glucoside (10) and acacetin-7-O-rutinoside (11), was isolated from the methanol extract of the aerial parts of Origanum syriacum. The structure elucidation of the isolated compounds was performed by spectroscopic and chromatographic methods.