A short update on the structure of drug binding sites on neurotransmitter transporters (original) (raw)

Ligand Selectivity among the Dopamine and the Serotonin Transporter Specified by the Forward Binding Reaction

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Molecular Mechanism of Citalopram and Cocaine Interactions with Neurotransmitter Transporters

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Comparative Molecular Field Analysis Using Selectivity Fields Reveals Residues in the Third Transmembrane Helix of the Serotonin Transporter Associated with Substrate and Antagonist Recognition

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The Isomeric Preference of an Atypical Dopamine Transporter Inhibitor Contributes to Its Selection of the Transporter Conformation

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Structure–activity relationships for substrate recognition by the human dopamine transporter

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Delineation of discrete domains for substrate, cocaine, and tricyclic antidepressant interactions using chimeric dopamine-norepinephrine transporters

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ligand Binding to the Serotonin Transporter: Equilibria, Kinetics, and Ion Dependence

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Mutational Mapping and Modeling of the Binding Site for (S)-Citalopram in the Human Serotonin Transporter

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Structure−Activity Relationships for a Novel Series of Dopamine D2-like Receptor Ligands Based on N-Substituted 3-Aryl-8-azabicyclo[3.2.1]octan-3-ol

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High- and low-affinity binding of S-citalopram to the human serotonin transporter mutated at 20 putatively important amino acid positions

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Structural Analysis of the Extracellular Entrance to the Serotonin Transporter Permeation Pathway

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Conformational changes in dopamine transporter intracellular regions upon cocaine binding and dopamine translocation

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Human dopamine transporter: the first implementation of a combined in silico/in vitro approach revealing the substrate and inhibitor specificities

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Interaction of cocaine-, benztropine-, and GBR12909-like compounds with wild-type and mutant human dopamine transporters: molecular features that differentially determine antagonist-binding properties

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Accessibility and Conformational Coupling in Serotonin Transporter Predicted Internal Domains

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The Journal of Neuroscience, 2002

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Molecular mechanism of serotonin transporter inhibition elucidated by a new flexible docking protocol

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Structure-Function of the High Affinity Substrate Binding Site (S1) of Human Norepinephrine Transporter

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Frontiers in Pharmacology, 2020

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Cocaine inhibition of ligand binding at dopamine, norepinephrine and serotonin transporters: A structure-activity study

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The binding sites for cocaine and dopamine in the dopamine transporter overlap

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Identification of the benztropine analog [125I]GA II 34 binding site on the human dopamine transporter

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Computational and biochemical docking of the irreversible cocaine analog RTI 82 directly demonstrates ligand positioning in the dopamine transporter central substrate-binding site

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A Conformationally Sensitive Residue on the Cytoplasmic Surface of Serotonin Transporter

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Mechanism for Cocaine Blocking the Transport of Dopamine: Insights from Molecular Modeling and Dynamics Simulations

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Structure-based Discovery of Conformationally Selective Inhibitors of the Serotonin Transporter

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A short update on the structure of drug binding sites on neurotransmitter transporters (original) (raw)

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