Faculty of 1000 evaluation for Structure-based discovery of prescription drugs that interact with the norepinephrine transporter, NET (original) (raw)
Structure-based discovery of prescription drugs that interact with the norepinephrine transporter, NET
John Irwin
Proceedings of the National Academy of Sciences, 2011
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Structure-Function of the High Affinity Substrate Binding Site (S1) of Human Norepinephrine Transporter
Prerna Jha
Frontiers in Pharmacology, 2020
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Structural basis of norepinephrine recognition and transport inhibition in neurotransmitter transporters
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Nature Communications, 2021
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A short update on the structure of drug binding sites on neurotransmitter transporters
Ingebrigt Sylte
BMC Research Notes, 2011
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Determination of Residues In the Norepinephrine Transporter That Are Critical for Tricyclic Antidepressant Affinity
B. Giros
Journal of Biological …, 2001
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Membrane Transporters: Structure, Function and Targets for Drug Design
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Topics in Medicinal Chemistry, 2008
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Journal of Biological Chemistry, 1994
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Barbara Zdrazil
MedChemComm, 2016
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rafal kurczab
Journal of Chemical Information and Modeling, 2014
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Desvenlafaxine Succinate Identifies Novel Antagonist Binding Determinants in the Human Norepinephrine Transporter
Robyn Richmond
Journal of Pharmacology and Experimental Therapeutics, 2007
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S33005, a novel ligand at both serotonin and norepinephrine transporters: I. Receptor binding, electrophysiological, and neurochemical profile in comparison with venlafaxine, reboxetine, citalopram, and clomipramine
Adrian Newman-Tancredi
The Journal of pharmacology and experimental therapeutics, 2001
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Comparative Molecular Field Analysis Using Selectivity Fields Reveals Residues in the Third Transmembrane Helix of the Serotonin Transporter Associated with Substrate and Antagonist Recognition
David Nichols
Journal of Pharmacology and Experimental Therapeutics, 2008
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Structure and Gating Dynamics of Na+/Cl– Coupled Neurotransmitter Transporters
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Frontiers in Molecular Biosciences
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Molecular characterization of neurotransmitter transporters
Ana Guadaño
Molecular Endocrinology, 1993
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The use of LeuT as a model in elucidating binding sites for substrates and inhibitors in neurotransmitter transporters
Claus J Loland
Biochimica et Biophysica Acta (BBA) - General Subjects, 2015
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Advanced Drug Delivery Reviews, 2006
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Structure-based Discovery of Conformationally Selective Inhibitors of the Serotonin Transporter
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Elucidation of common pharmacophores from analysis of targeted metabolites transported by the multispecific drug transporter—Organic anion transporter1 (Oat1)
Igor Tsigelny
Bioorganic & Medicinal Chemistry, 2011
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Neurotransmitter transporters: why dance with so many partners?
Marco A González Escudero
Current Opinion in Pharmacology, 2004
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Computational modeling to accelerate the identification of substrates and inhibitors for transporters that affect drug disposition
Sean Ekins
Clinical Pharmacology and Therapeutics, 2012
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The Mechanism of a Neurotransmitter:Sodium Symporter—Inward Release of Na+ and Substrate Is Triggered by Substrate in a Second Binding Site
Harel Weinstein
Molecular Cell, 2008
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Structural basis of organic cation transporter-3 inhibition
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Tyr-95 and Ile-172 in Transmembrane Segments 1 and 3 of Human Serotonin Transporters Interact to Establish High Affinity Recognition of Antidepressants
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Journal of Biological Chemistry, 2006
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Critical Amino Acid Residues in Transmembrane Span 7 of the Serotonin Transporter Identified by Random Mutagenesis
Gary Rudnick
Journal of Biological Chemistry, 1998
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Substrate-dependent proton antiport in neurotransmitter:sodium symporters
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Nature Chemical Biology, 2010
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Mikko Niemi, Volker Fischer
Nature Reviews Drug Discovery, 2010
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Conformational state interactions provide clues to the pharmacochaperone potential of serotonin transporter partial substrates
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Journal of Biological Chemistry
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Probing the Selectivity of Monoamine Transporter Substrates by Means of Molecular Modeling
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Molecular Informatics, 2013
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Antidepressant binding site in a bacterial homologue of neurotransmitter transporters
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Nature, 2007
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Current Advances in Studying Clinically Relevant Transporters of the Solute Carrier (SLC) Family by Connecting Computational Modeling and Data Science
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Computational and Structural Biotechnology Journal, 2019
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Human dopamine transporter: the first implementation of a combined in silico/in vitro approach revealing the substrate and inhibitor specificities
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Journal of biomolecular structure & dynamics, 2018
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