A trimethoprim derivative impedes antibiotic resistance evolution (original) (raw)
Analysis of mutational resistance to trimethoprim in Staphylococcus aureus by genetic and structural modelling techniques
Ian Chopra
Journal of Antimicrobial Chemotherapy, 2009
View PDFchevron_right
Development of antibacterial compounds that block evolutionary pathways to resistance
Sourav Chowdhury
2020
View PDFchevron_right
Structure-guided functional studies of plasmid-encoded dihydrofolate reductases reveal a common mechanism of trimethoprim resistance in Gram-negative pathogens
Heidi Erlandsen
Communications Biology
View PDFchevron_right
Discovery of Highly Trimethoprim-Resistant DfrB Dihydrofolate Reductases in Diverse Environmental Settings Suggests an Evolutionary Advantage Unrelated to Antibiotic Resistance
Joelle Pelletier
Antibiotics
View PDFchevron_right
Molecular Characterisation of Trimethoprim Resistance in Escherichia coli and Klebsiella pneumoniae during a Two Year Intervention on Trimethoprim Use
Gunnar Kahlmeter
PLoS ONE, 2010
View PDFchevron_right
Within-Population Distribution of Trimethoprim Resistance in Escherichia coli before and after a Community-Wide Intervention on Trimethoprim Use
Arnfinn Sundsfjord
View PDFchevron_right
A Conservative Amino Acid Mutation in the Chromosome‐Encoded Dihydrofolate Reductase Confers Trimethoprim Resistance in Streptococcus pneumoniae
William rodriguez
The Journal of Infectious Diseases, 1998
View PDFchevron_right
Evolutionary action of mutations reveals antimicrobial resistance genes in Escherichia coli
Benu Atri
Nature Communications
View PDFchevron_right
A Strategic Target Rescues Trimethoprim Sensitivity in Escherichia coli
Nagasuma Chandra
SSRN Electronic Journal, 2019
View PDFchevron_right
The Bacterial Genomic Context of Highly Trimethoprim-Resistant DfrB Dihydrofolate Reductases Highlights an Emerging Threat to Public Health
Claudèle Lemay-St-Denis, Joelle Pelletier
Antibiotics
View PDFchevron_right
Integron-Associated DfrB4, a Previously Uncharacterized Member of the Trimethoprim-Resistant Dihydrofolate Reductase B Family, Is a Clinically Identified Emergent Source of Antibiotic Resistance
Joelle Pelletier
Antimicrobial agents and chemotherapy, 2017
View PDFchevron_right
A single amino acid substitution in Staphylococcus aureus dihydrofolate reductase determines trimethoprim resistance
Hanno Langen
Journal of Molecular Biology, 1997
View PDFchevron_right
Genetic characterization of trimethoprim resistance in Haemophilus influenzae
Wil Goessens
Antimicrobial agents and chemotherapy, 1996
View PDFchevron_right
Effects of a previously selected antibiotic resistance on mutations acquired during development of a second resistance in Escherichia coli
Benno Ter Kuile
BMC Genomics, 2019
View PDFchevron_right
Intermediate Mutation Frequencies Favor Evolution of Multidrug Resistance in Escherichia coli
Ivan Matic
Genetics, 2005
View PDFchevron_right
Adaptation and Compensation in a Bacterial Gene Regulatory Network Evolving Under Antibiotic Selection
Vishwa Patel
2021
View PDFchevron_right
Genomic Analysis Reveals Distinct Concentration-Dependent Evolutionary Trajectories for Antibiotic Resistance in Escherichia coli
Tïtās Séñgùptã
Dna Research, 2014
View PDFchevron_right
Trimethoprim resistance in surface and wastewater is mediated by contrasting variants of the dfrB gene
Joelle Pelletier
The ISME Journal
View PDFchevron_right
Characterization of Dihydrofolate Reductase Genes from Trimethoprim-Susceptible and Trimethoprim-Resistant Strains of Enterococcus faecalis
Teresa Coque
1999
View PDFchevron_right
Bypass of genetic constraints during mutator evolution to antibiotic resistance
Alexandro Rodríguez-Rojas
Proceedings. Biological sciences / The Royal Society, 2015
View PDFchevron_right
Structure-Based Design of Dimeric Bisbenzimidazole Inhibitors to an Emergent Trimethoprim-Resistant Type II Dihydrofolate Reductase Guides the Design of Monomeric Analogues
Joelle Pelletier
ACS Omega
View PDFchevron_right
Prospective Screening of Novel Antibacterial Inhibitors of Dihydrofolate Reductase for Mutational Resistance
Kathleen Frey
Antimicrobial Agents and Chemotherapy, 2012
View PDFchevron_right
Identification of a Novel Trimethoprim Resistance Gene, dfrK , in a Methicillin-Resistant Staphylococcus aureus ST398 Strain and Its Physical Linkage to the Tetracycline Resistance Gene tet (L)
Stefan Schwarz
Antimicrobial Agents and Chemotherapy, 2008
View PDFchevron_right
Analysis of genetic localization of the type I trimethoprim resistance gene from Escherichia coli isolated in Finland
Mikael Skurnik
Antimicrobial Agents and Chemotherapy, 1991
View PDFchevron_right
Towards the understanding of resistance mechanisms in clinically isolated trimethoprim-resistant, methicillin-resistant Staphylococcus aureus dihydrofolate reductase
Kathleen Frey
Journal of Structural Biology, 2010
View PDFchevron_right
Dominant resistance and negative epistasis can limit the co-selection of de novo resistance mutations and antibiotic resistance genes
Mostafa Ellabaan
Nature Communications
View PDFchevron_right
Genomic evolution of antibiotic resistance is contingent on genetic background following a long-term experiment with Escherichia coli
Joseph Graves Jr
bioRxiv (Cold Spring Harbor Laboratory), 2020
View PDFchevron_right
Compatibility of Evolutionary Responses to Constituent Antibiotics Drive Resistance Evolution to Drug Pairs
Mostafa Ellabaan
Molecular Biology and Evolution, 2021
View PDFchevron_right
Frequency of antibiotic application drives rapid evolutionary adaptation of Escherichia coli persistence
Bram Van Den Bergh, Natalie Verstraeten, Jan Michiels
View PDFchevron_right
Mutations in the Dihydrofolate Reductase Gene of Trimethoprim-Resistant Isolates of Streptococcus pneumoniae
Peter Adrian
1997
View PDFchevron_right
Changes in Intrinsic Antibiotic Susceptibility during a Long-Term Evolution Experiment with Escherichia coli
Otmane Lamrabet
MBio, 2019
View PDFchevron_right
The unconstrained evolution of fast and efficient antibiotic-resistant bacterial genomes
Fabio Gori
Nature Ecology & Evolution, 2017
View PDFchevron_right