Critical review of Albizia lebbeck- A multi potent drug (original) (raw)
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Therapeutic Potentials of Shirisha (Albizia lebbeck Benth) – A Review Review article
2016
Albizia lebbeck Benth. is a large, erect, unarmed, deciduous, spreading tree belonging to the family Fabaceae (Formerly Leguminosae), member of the subfamily Mimosaceae. It is found throughout India, ascending to 900m in the Himalayas and also in the islands of Andaman. It contains saponins, macrocyclic alkaloids, phenolic glycosides and flavonoids. In Ayurveda, Albizia lebbeck Benth. is familiar as Shirisha and it has been attributed with properties like Vishaghna (anti-poisonous) and emphasized its efficacy in Visarpa (Erysipelas), Hicca (Hiccup), Shwasa (Breathlessness), Kasa (Cough) etc. Researches of recent past have also reported anti-inflammatory, anti-histaminic, anti-anaphylactic, anti-asthmatic, anti-microbial properties of the plant. Saponins isolated from the methanolic extract of bark and pod of Albizia lebbeck Benth. have found to possess anti-spermatogenic effect. The current review revealed that, the plant Shirisha has a number of potentials in therapeutic field.
Ayurvedic Treatment of Poisoning: Contemporary Scenario
Agadtantra is the clinical branch of Ashtang Ayurveda dealing with poisons, their characteristics, diagnosis & treatment covered under Sthavara, Jangma, Dooshi visha & Gara visha. Poisons encountered today are different from those of ancient times. But Ayurvedic principles like 24 modalities should prove useful. Many formulations are available for Sthavara visha, Jangam visha, Dooshi visha & Gara visha. Practices of traditional Agadtantra for snake bites and skin diseases survive in its original form only in Kerala. Only a few plant species have been scientifically investigated by in-vitro & pre-incubation studies. All these formulations are not supported by in-vivo studies. There is need to evaluate the utility of Ayurvedic toxicology & it is essential to test all the formulations according to FDA regulations.
Journal of ayurveda and integrated medical sciences, 2022
medicinal plants become rare, endangered, and threatened (RET). It is the need of time to find the alternative part of use from the same plant having equally active phytochemical and therapeutic potential. Shirisharishta is a well-known formulation developed by ancient scholars by applying specific pharmaceutical procedures to get maximum therapeutic effect. Shirisha (Albizzia lebbeck Benth.) is a drug that draws the attention because of its multi-prolonged utility influencing the human life. Albeit Ayurvedic classics instruct of its high utility in treating the symptom complex due to Visha or the venomous poison, a lot of discrete references point out its utility in a variety of diseases such as Shwasa, etc. The plant is reported to have various pharmacological properties like antiasthmatic, antihistaminic, anti-protozoal, hypoglycaemic, antibacterial, antiseptic and antitubercular etc. properties. [1] Most of the recent studies are reported about the pharmacological actions of it's bark, leaves, pods and fruits, but almost negligible
Conceptual Study on Anti-Toxic Action of Kshara Agada: A Review
International Journal of Research in Ayurveda & Pharmacy, 2017
Agada Tantra is a specialized branch of Ayurveda which mainly deals with Visha (Poison) and its management. There are number of Agada Yogas (formulations) which are unique because of the potent ingredients which are faster in action. Kshara Agada is one among the several Agada Yogas which is explained in Charaka Samhita and Sushruta Samhita. According to Acharaya Charaka, Kshara Agada is a formulation where Palasha Kshara is prepared and several other vishaghna drugs are added to it. It is indicated in several complications of Visha such as Sotha (inflammation), Gulma (bloating), Twak dosa (skin ailments), Pandu (anaemia) etc. The ingredients are having antioxidant, antibacterial and hepatoprotective action. The main objective of this article is to discuss the therapeutic and pharmacological properties of Kshara Agada as respect to toxicity.
Phyto-Pharmacological Profile of Albizzia lebbeck
2010
The plant Albizzia lebbeck Benth. [Mimosaceae] is reported to possess anti-asthmatic, anti-inflammatory, antifertility and anti-diarrhoeal properties. Albizzia lebbeck is an important source of chemicals of melacacidin, D-catechin, b-Sitosterol, Albiziahexoside, betulnic acids which are effective as antiseptic, anti-dysenteric, anti-tubercular and used in bronchitis, leprosy, paralysis, helmenth infection etc. Hence in view of immense medicinal importance of the plant this review is therefore an effort to compile all the information reported on its phytochemical and pharmacological activities. This information will be helpful to create interest towards the plant and may be useful in developing new formulations, which are more effective and have more therapeutic value.
Ayapodi Elagam (A.E) was used in Siddha system of medicine for many years to treat Pandu (Anemia). This medicine contains Nellikai, Keezhanelli, Karisalai and Ayam. These herbs are helps to improve the blood to correct the anemia. This study was carried out to evaluate the acute and chronic toxic effect on Ayapodi Elagam and to determine the LD50. The toxicity study was done as per the guidelines of world health organization (WHO) guideline. As the herbs and Ayam were used for treating anemia by traditional practitioners for years together, the toxicity study was also proposed to study in both sexes. In acute study the animals were divided into two groups A.E was administered at 5000mg/kg orally and animals were observed for toxic sign at 0,5,1,4,24 hour and for 14 days. In chronic toxicity study A.E was administered at 450,900 and 1800 mg/kg body weight/day to 3 groups of animal, respectively. The distilled water was administered to control animals. The result showed that the acute toxicity study of A.E. at the dose level of 5000mg/kg does not produce any toxic sign and mortality among the experimental groups and the LD50 value of the drug was found to be more than 5000mg/kg bodyweight. The weight of rats, wellness parameters, mortality, hematological parameters, biochemical parameters and histological analysis of all vital organs were observed to know the chronic toxic effect of the drug. All the parameters of the study do not show the any significant chances between the control and experimental groups.
Pharmacognositical and phytochemical analysis of stem bark of Albizzia lebbeck Benth
Albizzia lebbeck Benth. is one of the significant plant of Ayurveda, belongs to the family Fabaceae. Ethno medicinally A. lebbeck is claimed to be used in the management of leprosy, wound, asthama, urticaria, migraine, worm infection and others. The present study has been carried out to establish the stem bark of the plant for its morphological, microscopical and physicochemical characters along with different phytochemical qualitative tests, as per Ayurvedic Pharmacopoeia of India. Microscopy of the stem bark showed dead tissue of rhytidoma, prismatic crystals of calcium oxalate, and tangential bands of ceratenchyma. Physicochemical parameters showed loss on drying (7.15%w/w), ash value (4.05%w/w), acid insoluble ash (0.33%w/w), water soluble extractive (15.46%w/v) and alcohol soluble extractive (14.24%w/v). Preliminary phytochemical analysis for the presence of various functional groups revealed the presence of flavonoids, proteins, saponins, tannins and free amino acids. The observed data can be useful to identify and standardize of stem bark of Albizzia lebbeck Benth.
Pharmacognostic and Acute Toxicity Studies of the Albizia chevalieri Hams Mimosaceae
Albizia chevalieri Hams (Mimosaceae), mostly found in the Northern Sahel Savannah region of Nigeria as well as in Nigér and Senegal is a tree of the acacia type with a long list of folklore therapeutic claims which include its use as purgative, taenicidal, cough remedy, dysentery, cancer, diabetes mellitus, tuberculosis and snake bite remedy. The stem bark was collected, dried and powdered. Physicochemical constants vis; moisture content, total ash, acid insoluble ash, water soluble ash, alcohol-soluble extractive value, water-soluble extractive value and elemental analysis vis ; acid digestion of the powdered stem was carried out using standard methods. Findings from this study revealed the presence of some diagnostic microscopical features such as calcium oxalate, starch, gum/mucilage, lignin,
SIRAS (ALBIZIA LEBBECK (L.) BENTH.) AND ITS MEDICINAL USES IN UNANI MEDICINE-A REVIEW
Cellmed, 2020
Higher incidences of adverse reaction associated with the prolonged use of synthetic drugs has once again increased the faith of humans in the traditional systems of medicine and motivated them to return back towards the clinical proven remedies for the treatment. It is also true that number of modern medications used in the present scenario, were developed from various plants. In Unani System of medicine, numerous herbal drugs are mentioned for medicinal purpose. Siras (Albizia lebbeck (L.) Benth.) is one of them. It is found all over India. Almost all parts of this plant are used for the treatment of ailments such as migraine, conjunctivitis, diarrhea, jaundice, skin problems, asthma etc. Many chemical constituents have been isolated from Albizia lebbeck such as lebbekannin, echinocystic acid, flavonoids, Linoleic acid, saponins etc. This review highlights the medicinal properties and therapeutic uses of Albizia lebbeck and scientific studies conducted on the drug in human and animal models that will provide the further research direction.