Hepatitis B virus core protein phosphorylation: Identification of the SRPK1 target sites and impact of their occupancy on RNA binding and capsid structure (original) (raw)

Central Role of a Serine Phosphorylation Site within Duck Hepatitis B Virus Core Protein for Capsid Trafficking and Genome Release

Journal of Biological Chemistry, 2003

Structural Organization of Pregenomic RNA and the Carboxy-Terminal Domain of the Capsid Protein of Hepatitis B Virus

PLoS Pathogens, 2012

Core protein phosphorylation modulates pregenomic RNA encapsidation to different extents in human and duck hepatitis B viruses

James Fielding

Journal of Virology, 2000

Phosphorylation of hepatitis B virus core C-terminally truncated protein (Cp149) by PKC increases capsid assembly and stability

hang kang

Biochemical Journal, 2008

Localization of the C terminus of the assembly domain of hepatitis B virus capsid protein: Implications for morphogenesis and organization of encapsidated RNA

Proceedings of the National Academy of Sciences, 1997

Effect of core protein phosphorylation by protein kinase C on encapsidation of RNA within core particles of hepatitis B virus. J Virol 68: 7993-8000

Journal of Virology

A Kinase Chaperones Hepatitis B Virus Capsid Assembly and Captures Capsid Dynamics in vitro

PLoS Pathogens, 2011

Effect of core protein phosphorylation by protein kinase C on encapsidation of RNA within core particles of hepatitis B virus

Journal of Virology, 1994

Hepatitis B Virus Capsid Assembly Modulators, but Not Nucleoside Analogs, Inhibit the Production of Extracellular Pregenomic RNA and Spliced RNA Variants

Christine Mary Espiritu

Antimicrobial Agents and Chemotherapy

Hepatitis B Virus Core Protein Phosphorylation Sites Affect Capsid Stability and Transient Exposure of the C-terminal Domain

The Journal of biological chemistry, 2015

A Theoretical Study of SRPK Interaction with the Flexible Domains of Hepatitis B Capsids

Jehoon Kim

Biophysical Journal, 2014

Full-Length Hepatitis B Virus Core Protein Packages Viral and Heterologous RNA with Similarly High Levels of Cooperativity

Journal of Virology, 2010

Phosphorylation of the duck hepatitis B virus capsid protein associated with conformational changes in the C terminus

Minshu Yu

Journal of virology, 1994

Phosphoacceptors threonine 162 and serines 170 and 178 within the carboxyl-terminal RRRS/T motif of the hepatitis B virus core protein make multiple contributions to hepatitis B virus replication

Kyongmin Kim

Journal of virology, 2014

A sensitive procedure for mapping the boundaries of RNA elements binding in vitro translated proteins defines a minimal hepatitis B virus encapsidation signal

Nucleic Acids Research, 1996

Evidence for Multiple Distinct Interactions between Hepatitis B Virus P Protein and Its Cognate RNA Encapsidation Signal during Initiation of Reverse Transcription

PLoS ONE, 2013

The Hepatitis B Virus Nucleocapsid—Dynamic Compartment for Infectious Virus Production and New Antiviral Target

Biomedicines

Interfering with capsid formation: A practicable antiviral strategy against hepatitis B virus?

Hepatology, 2004

Expression of viral polymerase and phosphorylation of core protein determine core and capsid localization of the human hepatitis B virus

Journal of General Virology, 2014

Hepatitis B Virus Nucleocapsids Formed by Carboxy-Terminally Mutated Core Proteins Contain Spliced Viral Genomes but Lack Full-Size DNA

Journal of Virology, 2004

In vitro functional analysis of gRNA sites regulating assembly of hepatitis B virus

Nikesh Patel

Communications Biology

Nuclear Entry of Hepatitis B Virus Capsids Involves Disintegration to Protein Dimers followed by Nuclear Reassociation to Capsids

Paul Pumpens

PLoS Pathogens, 2009

Inhibition of protein kinase C phosphorylation of hepatitis B virus capsids inhibits virion formation and causes intracellular capsid accumulation

Cellular Microbiology, 2010

Core protein: A pleiotropic keystone in the HBV lifecycle

Antiviral Research, 2015

Cis-preferential recruitment of duck hepatitis B virus core protein to the RNA/polymerase preassembly complex

Hepatology, 2002

A VLP Library of C-Terminally Truncated Hepatitis B Core Proteins: Correlation of RNA Encapsidation with a Th1/Th2 Switch in the Immune Responses of Mice

Irina Sominskaya, Ivars Petrovskis

PLoS ONE, 2013

HBV RNA pre-genome encodes specific motifs that mediate interactions with the viral core protein that promote nucleocapsid assembly

Nikesh Patel

Nature microbiology, 2017

A Small 2'-OH- and Base-dependent Recognition Element Downstream of the Initiation Site in the RNA Encapsidation Signal Is Essential for Hepatitis B Virus Replication Initiation

Journal of Biological Chemistry, 1999

The arginine-rich domain of the hepatitis B virus core protein is required for pregenome encapsidation and productive viral positive-strand DNA synthesis but not for virus assembly

Journal of Virology, 1992

Running title : Targeting virus assembly Small-Molecule Effectors of Hepatitis B Virus Capsid Assembly Give Insight Into Virus Lifecycle

2008

Hepatitis B virus Core protein nuclear interactome identifies SRSF10 as a host RNA-binding protein restricting HBV RNA production

Uri Lopatin

2020

Assembly and Release of Hepatitis B Virus

Cold Spring Harbor perspectives in medicine, 2015

Analysis of the nuclear localization signal of the hepatitis B virus capsid

Posttranslational modifications of HBV core protein

Jan Weber

Acta virologica, 2020