Effect of purified epoxide hydrolase on metabolic activa-tion and binding of benzo(a)pyrene to exogenous DNA. Shift of the activation pathway (original) (raw)

Microsome-Mediated Benzo(A)Pyrene-Dna Binding and Inhibition by Cytosolic Fractions from Liver and Skin of Adult and Weanling Rats

Abdolamir Allameh

2001

View PDFchevron_right

Interaction of Benzo(a)pyrene and Its Dihydrodiol-Epoxide Derivative with Nuclear and Mitochondrial DNA in C3H10T½ Cell Cultures

Joseph Backer

Cancer Research, 1982

View PDFchevron_right

Beta carotene and its oxidation products have different effects on microsome mediated binding of benzo[a]pyrene to DNA

Rafael Cueto

Free Radical Biology and Medicine, 1999

View PDFchevron_right

Epoxide hydrase activity in liver nuclei: Hydration of benzo[a]pyrene-4,5-oxide and styrene oxide

William Bornstein

Chemico-Biological Interactions, 1978

View PDFchevron_right

Formation of benzo[a]pyrene-DNA adducts by microsomal enzymes: Comparison of maternal and fetal liver, fetal hematopoietic cells and placenta

Margaret James

Chemico-Biological Interactions, 1987

View PDFchevron_right

Identification and quantitation of benzo[a]pyrene-DNA adducts formed by rat liver microsomes in vitro

Ryszard Jankowiak

Chemical Research in Toxicology, 1992

View PDFchevron_right

The in vitro metabolism and covalent binding of benzo[a]pyrene to dna catalysed by trout liver microsomes

Jorma Ahokas

Chemico-Biological Interactions, 1979

View PDFchevron_right

Identification and Quantitation of Dibenzo[a,l]pyrene-DNA Adducts Formed by Rat Liver Microsomes in Vitro: Preponderance of Depurinating Adducts

Ryszard Jankowiak

Biochemistry, 1995

View PDFchevron_right

Detection and Quantitation of Benzo[a]pyrene-Derived DNA Adducts in Mouse Liver by Liquid Chromatography−Tandem Mass Spectrometry: Comparison with 32P-Postlabeling

Raj Singh

Chemical Research in Toxicology, 2006

View PDFchevron_right

Nuclear metabolism. II. Further studies on epoxide hydrolase activity

E. Garattini

Chemico-Biological Interactions, 1981

View PDFchevron_right

Detection of benzo(a)pyrene diol epoxide-DNA adducts in mononuclear white blood cells by CE immunoassay and its application to studying the effect of glutathione depletion

Michael Weinfeld

ELECTROPHORESIS, 2009

View PDFchevron_right

Metabolic activation of aromatic hydrocarbons in purified rat liver nuclei: induction of enzyme activities and binding to DNA with and without monooxygenase-catalyzed formation of active oxygen

Ercole Cavalieri

Proceedings of the National Academy of Sciences, 1976

View PDFchevron_right

Microsome-mediated bioactivation of dibenzo[a,l]pyrene and identification of DNA adducts by 32P-postlabeling

Jamal Arif

Carcinogenesis, 1997

View PDFchevron_right

Metabolic activation of benzo[a]pyrene in two fetal mouse hepatocyte lines: induction of DNA adducts and micronuclei

Paola Venier, L. Celotti

Mutation research, 1996

View PDFchevron_right

<emph type="2">In Vitro</emph> and <emph type="2">In Vivo</emph> Studies on Oxygen Free Radical and DNA Adduct Formation in Rat Lung and Liver during Benzo[a]pyrene Metabolism

Theo de Kok, Marijn Emans

Free Radical Research, 2004

View PDFchevron_right

The effect of neighbouring bases on G-specific DNA cleavage mediated by treatment with the anti -diol epoxide of benzo(a)pyrene in vitro

Victor V Lobanenkov

Carcinogenesis, 1986

View PDFchevron_right

Evidence for the involvement of a diol-epoxide in the binding of 7,12-dimethylbenz(a)anthracene to DNA in cells in culture

J. Nebzydoski

Chemico-Biological Interactions, 1978

View PDFchevron_right

Binding of [3H]Benzo(α)pyrene to Natural and Synthetic Nucleic Acids in a Subcellular Microsomal System

Concetta Pietropaolo

Cancer Research

View PDFchevron_right

32P-Postlabeling analysis of lipophilic DNA adducts resulting from interaction with (±)-3-hydroxy-trans-7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydro-benzo[a]pyrene

Nancy Shappell

Chemico-Biological Interactions, 1999

View PDFchevron_right

Exposure to benzo[a]pyrene of Hepatic Cytochrome P450 Reductase Null (HRN) and P450 Reductase Conditional Null (RCN) mice: Detection of benzo[a]pyrene diol epoxide-DNA adducts by immunohistochemistry and 32P-postlabelling

Michaela Moserová

Toxicology Letters, 2012

View PDFchevron_right

Formation of stable adducts and absence of depurinating DNA adducts in cells and DNA treated with the potent carcinogen dibenzo[a,l]pyrene or its diol epoxides

William Baird

Proceedings of the National Academy of Sciences, 1997

View PDFchevron_right

Identification and Quantification of Stable DNA Adducts Formed from Dibenzo[ a,l ]pyrene or Its Metabolites in Vitro and in Mouse Skin and Rat Mammary Gland

Ercole Cavalieri

Chemical Research in Toxicology, 2005

View PDFchevron_right

Effect of nuclear environment on the distribution of benzo[ a ]pyrene diol epoxide-induced adducts in the HPRT gene of human fibroblasts

Justin McCormick

Carcinogenesis, 1996

View PDFchevron_right

Role of activated oxygen species in benzo[a]pyrene: DNA adduct formation in vitro

Piotr Bryla

Free Radical Biology and Medicine, 1991

View PDFchevron_right

H2AX phosphorylation in A549 cells induced by the bulky and stable DNA adducts of benzo[a]pyrene and dibenzo[a,l]pyrene diol epoxides

Ian Cotgreave

Chemico-Biological Interactions, 2009

View PDFchevron_right

The Covalent Binding of Enantiomeric Benzo [A] Pyrene Diol Epoxides to Double Stranded Dna is Stereoselective

Thomas Meehan

Lawrence Berkeley National Laboratory, 2011

View PDFchevron_right