Activation Domain-dependent Degradation of Somatic Wee1 Kinase (original) (raw)

Casein Kinase 1δ-dependent Wee1 Protein Degradation

Scott Simanski

Journal of Biological Chemistry, 2014

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Redundant Ubiquitin Ligase Activities Regulate Wee1 Degradation and Mitotic Entry

Scott Simanski

Cell Cycle, 2007

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Cyclin-dependent kinase (CDK) phosphorylation destabilizes somatic Wee1 via multiple pathways

Tony Hunter

Proceedings of the National Academy of Sciences, 2005

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Casein Kinase 1 -dependent Wee1 Protein Degradation

Scott Simanski

Journal of Biological Chemistry, 2014

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M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCF -TrCP

Tony Hunter

Proceedings of the National Academy of Sciences, 2004

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Binding of 14-3-3beta to the carboxyl terminus of Wee1 increases Wee1 stability, kinase activity, and G2-M cell population

R. Booher

Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, 2000

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Structural basis of Wee kinases functionality and inactivation by diverse small molecule inhibitors

Norbert Berndt

Journal of medicinal chemistry, 2017

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Human Cdc14A regulates Wee1 stability by counteracting CDK-mediated phosphorylation

Sara Ovejero, MARÍA PAZ SACRISTÁN MARTÍN, Avelino Bueno

Molecular Biology of the Cell, 2012

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Functional genetic screen identifies increased sensitivity to WEE1 inhibition in cells with defects in Fanconi Anaemia and HR pathways

Christopher Lord

Molecular cancer therapeutics, 2015

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An UltraHigh Throughput Cell-Based Screen for Wee1 Degradation Inhibitors

Scott Simanski

Journal of Biomolecular Screening, 2010

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A haploid genetic screen identifies the G 1 /S regulatory machinery as a determinant of Wee1 inhibitor sensitivity

Xavier Bisteau

Proceedings of the National Academy of Sciences, 2015

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SCFPof3 and SCFPof1 regulate Wee1 degradation and mitotic entry in fission yeast

Yuan Yi

Journal of cell science, 2017

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WEE1 Inhibition Enhances Anti-Apoptotic Dependency as a Result of Premature Mitotic Entry and DNA Damage

Mathilde de Jong

Cancers

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Unique functions of CHK1 and WEE1 underlie synergistic anti-tumor activity upon pharmacologic inhibition

Stuart Shumway, Nathan Miselis, Andrew Bloecher

Cancer Cell International, 2012

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Structure and Inhibition of the Human Cell Cycle Checkpoint Kinase, Wee1A Kinase

James Dickson

Structure, 2005

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Pharmacological targeting the ATR–CHK1–WEE1 axis involves balancing cell growth stimulation and apoptosis

Victor Wang

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Preclinical evaluation of the WEE1 inhibitor MK-1775 as single-agent anticancer therapy

S. Fawell, Stuart Shumway

Molecular cancer therapeutics, 2013

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Plant WEE1 kinase is cell cycle regulated and removed at mitosis via the 26S proteasome machinery

Maria Bitonti

Journal of Experimental Botany, 2013

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Wee1 Rather Than Plk1 Is Inhibited by AZD1775 at Therapeutically Relevant Concentrations

Rosa Della Monica

Cancers

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Chk1 inhibition and Wee1 inhibition combine synergistically to impede cellular proliferation

Stefan Gross

Http Dx Doi Org 10 4161 Cbt 12 9 17673, 2011

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In silico analysis of kinase expression identifies WEE1 as a gatekeeper against mitotic catastrophe in glioblastoma

Angela van Tilborg, Dirk Geerts

Cancer cell, 2010

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Concerted mechanism of Swe1/Wee1 regulation by multiple kinases in budding yeast

Porntip Supavilai

The EMBO Journal, 2005

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The Cyclin-dependent Kinase Activator, Spy1A, Is Targeted for Degradation by the Ubiquitin Ligase NEDD4

Lisa Porter

Journal of Biological Chemistry, 2008

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A bifunctional regulatory element in human somatic Wee1 mediates cyclin A/Cdk2 binding and Crm1-dependent nuclear export

Roland Dunbrack

2010

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UCN-01 Abrogates G2 Arrest through a Cdc2-dependent Pathway That Is Associated with Inactivation of the Wee1Hu Kinase and Activation of the Cdc25C Phosphatase

A. Senderowicz

Journal of Biological Chemistry, 1998

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Arabidopsis WEE1 Kinase Controls Cell Cycle Arrest in Response to DNA Damage

Kristof De Schutter

THE PLANT CELL ONLINE, 2007

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Wee1B Is an Oocyte-Specific Kinase Involved in the Control of Meiotic Arrest in the Mouse

Maria Paronetto

Current Biology, 2005

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A role for Hsp90 in cell cycle control: Wee1 tyrosine kinase activity requires interaction with Hsp90

Rosa Aligué

The EMBO Journal, 1994

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Substrate Competition as a Source of Ultrasensitivity in the Inactivation of Wee1

James Ferrell

Cell, 2007

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Murine Wee1 Plays a Critical Role in Cell Cycle Regulation and Pre-Implantation Stages of Embryonic Development

Cuiling Li

International Journal of Biological Sciences, 2006

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Wee1 kinase alters cyclin E/Cdk2 and promotes apoptosis during the early embryonic development of Xenopus laevis

Carla Finkielstein

BMC developmental biology, 2007

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