Potential of Nanoparticles Integrated with Antibacterial Properties in Preventing Biofilm and Antibiotic Resistance (original) (raw)
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Despite numerous existing potent antibiotics and other antimicrobial means, bacterial infections are still a major cause of morbidity and mortality. Moreover, the need to develop additional bactericidal means has significantly increased due to the growing concern regarding multidrug-resistant bacterial strains and biofilm associated infections. Consequently, attention has been especially devoted to new and emerging nanoparticle-based materials in the field of antimicrobial chemotherapy. The present review discusses the activities of nanoparticles as an antimicrobial means, their mode of action, nanoparticle effect on drug-resistant bacteria, and the risks attendant on their use as antibacterial agents. Factors contributing to nanoparticle performance in the clinical setting, their unique properties, and mechanism of action as antibacterial agents are discussed in detail.
Bacterial infections cause 300 million cases of severe illness each year worldwide. Rapidly accelerating drug resistance further exacerbates this threat to human health. While dispersed (planktonic) bacteria represent a therapeutic challenge, bacterial biofilms present major hurdles for both diagnosis and treatment. Nanoparticles have emerged recently as tools for fighting drug-resistant planktonic bacteria and biofilms. In this review, we present the use of nanoparticles as active antimicrobial agents and drug delivery vehicles for antibacterial therapeutics. We further focus on how surface functionality of nanomaterials can be used to target both planktonic bacteria and biofilms. PubMed Abstract | Free Full Text 2. Costerton JW, Cheng KJ, Geesey GG, et al.: Bacterial biofilms in nature and disease. Annu Rev Microbiol. 1987; 41: 435-64. PubMed Abstract | Publisher Full Text 3. Costerton JW, Stewart PS, Greenberg EP: Bacterial biofilms: a common cause of persistent infections. Science. 1999; 284(5418): 1318-22. PubMed Abstract | Publisher Full Text 4. Spellberg B, Powers JH, Brass EP, et al.: Trends in antimicrobial drug development: implications for the future. Clin Infect Dis. 2004; 38(9): 1279-86. PubMed Abstract | Publisher Full Text 5. De M, Ghosh PS, Rotello VM: Applications of Nanoparticles in Biology. Adv Mater. 2008; 20(22): 4225-41. Publisher Full Text 6. Davis ME, Chen ZG, Shin DM: Nanoparticle therapeutics: an emerging treatment modality for cancer. Nat Rev Drug Discov. 2008; 7(9): 771-82. PubMed Abstract | Publisher Full Text 7. Jiang Z, Le ND, Gupta A, et al.: Cell surface-based sensing with metallic nanoparticles. Chem Soc Rev. 2015; 44(13): 4264-74. PubMed Abstract | Publisher Full Text | Free Full Text 8. Daniel MC, Astruc D: Gold nanoparticles: assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology. Chem Rev. 2004; 104(1): 293-346. PubMed Abstract | Publisher Full Text 9. Falagas ME, Kasiakou SK: Colistin: the revival of polymyxins for the management of multidrug-resistant gram-negative bacterial infections. Clin Infect Dis. 2005; 40(9): 1333-41. PubMed Abstract | Publisher Full Text 10. Cui L, Iwamoto A, Lian JQ, et al.: Novel mechanism of antibiotic resistance originating in vancomycin-intermediate Staphylococcus aureus. Antimicrob Agents Chemother. 2006; 50(2): 428-38. PubMed Abstract | Publisher Full Text | Free Full Text 11. Li XZ, Nikaido H: Efflux-mediated drug resistance in bacteria. Drugs. 2004; 64(2): 159-204. PubMed Abstract | Publisher Full Text 12. Livermore DM: beta-Lactamases in laboratory and clinical resistance. Clin Microbiol Rev. 1995; 8(4): 557-84. PubMed Abstract | Free Full Text 13. Davies J, Wright GD: Bacterial resistance to aminoglycoside antibiotics. Trends Microbiol. 1997; 5(6): 234-40. PubMed Abstract | Publisher Full Text 14. Courvalin P: Vancomycin resistance in gram-positive cocci. Clin Infect Dis. 2006; 42(Suppl 1): S25-34. PubMed Abstract | Publisher Full Text 15. Hajipour MJ, Fromm KM, Ashkarran AA, et al.: Antibacterial properties of nanoparticles. Trends Biotechnol. 2012; 30(10): 499-511. PubMed Abstract | Publisher Full Text 16. Miller KP, Wang L, Benicewicz BC, et al.: Inorganic nanoparticles engineered to attack bacteria. Chem Soc Rev. 2015; 44(21): 7787-807.
A Recent advances in nanoparticles as antibacterial agent
ADMET and DMPK, 2022
Recently, the rapid increase in antibiotic-resistant pathogens has caused serious health problems. Researchers are searching for alternative antimicrobial substances to control or prevent infections caused by pathogens. Different strategies are used to develop effective antibacterial agents, and in this respect, nanoparticles are undoubtedly promising materials. Nanoparticles act by bypassing drug resistance mechanisms in bacteria and inhibiting biofilm formation or other important processes related to their virulence potential. Nanoparticles can penetrate the cell wall and membrane of bacteria and act by disrupting important molecular mechanisms. In combination with appropriate antibiotics, NPs may show synergy and help prevent the developing global bacterial resistance crisis. Furthermore, due to characteristics such as enhanced biocompatibility and biodegradability, polymer-based nanoparticles enable the development of a wide range of medical products. Antibacterial applications ...
Potent Antibacterial Nanoparticles against Biofilm and Intracellular Bacteria
The chronic infections related to biofilm and intracellular bacteria are always hard to be cured because of their inherent resistance to both antimicrobial agents and host defenses. Herein we develop a facile approach to overcome the above conundrum through phosphatidylcholine-decorated Au nanoparticles loaded with gentamicin (GPA NPs). The nanoparticles were characterized by scanning electron microscopy (SEM), dynamic light scattering (DLS) and ultraviolet−visible (UV−vis) absorption spectra which demonstrated that GPA NPs with a diameter of approximately 180 nm were uniform. The loading manner and release behaviors were also investigated. The generated GPA NPs maintained their antibiotic activities against planktonic bacteria, but more effective to damage established biofilms and inhibited biofilm formation of pathogens including Gram-positive and Gram-negative bacteria. In addition, GPA NPs were observed to be nontoxic to RAW 264.7 cells and readily engulfed by the macrophages, which facilitated the killing of intracellular bacteria in infected macrophages. These results suggested GPA NPs might be a promising antibacterial agent for effective treatment of chronic infections due to microbial biofilm and intracellular bacteria.
Proceedings of the International Conference on Science Technology and SocialSciences – Physics, Material and Industrial Technology (ICONSTAS-PMIT 2023) , Advances in EngineeringResearch 238, 2024
Biofilms are complex microbial communities attached to surfaces, encapsulated in a protective extracellular matrix, leading to increased antibiotic resistance, and contributing to persistent infections and widespread diseases. This mini review aims to examine the antibiofilm potential of nanoparticles (NPs) such as graphene, zinc oxide, hydroxyapatite, silicon dioxide, sodium silicate, titanium oxide, silver, gold, palladium, and tungsten. These NPs employ various mechanisms to disrupt biofilms, including sharp nanosheet attacks on cell membranes, alteration of mRNA expression, generation of reactive oxygen species that cause oxidative damage to essential biomolecules, and destabilization of the biofilm matrix. These multifaceted mechanisms underscore the potential of NPs in combating biofilms and addressing antibiotic resistance, offering promising avenues for future medical, industrial, and environmental applications.
Role of nanoparticles in elimination of biofilm produced by pathogenic bacteria
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Biofilm is a structured conglomeration of bacteria entrenched in a polymer matrix that is self-produced and contains DNA, polysaccharide, protein, and cause chronic infections. Pseudomonas aeruginosa lung infection is one of the well stated examples of pathogenic biofilms in cystic fibrosis patients. Due to mutating nature of the pathogens high antibiotic resistance will develop that make antibiotic treatment ineffective against repeated infections that are related to indwelling medical devices. Normally it was considered that nanoparticles are not larger than 100 nm, and their development to fight infection has gained popularity over the several decades. Different types of nanoparticles were introduced to treat biofilm infections in which silver nanoparticles were considered to be more efficient than all others. Maximum zone of inhibition in case of silver nanoparticles was found to be 40 mm against S.aureus, whereas maximum zone of inhibition with ZnO nanoparticles was 16 mm again...
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