Carrier rate of hepatitis B surface antigen (HBsAg) among urban pregnant women in a secondary health facility in Maiduguri, Northeastern Nigeria (original) (raw)
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Journal of Basic and Clinical Reproductive Sciences, 2012
Infections due to viral hepatitis are systemic diseases caused by viruses A-E that mostly involve the liver. [1] It is a DNA virus which belongs to the family Hepadnaviridae. The virus was first discovered as 'Australian antigen' and later named hepatitis B surface antigen (HBsAg) in the blood of patients. Hepatitis B e antigen (HBeAg) was discovered later as a marker for patients at a high risk for transmission of the disease. [2] Infection caused by hepatitis B virus (HBV) is a serious public health problem causing about two billion infections worldwide. [3] Transmission is commonly through blood transfusion, blood products, body fluids (urine, semen, sweat, saliva, and tears), use of contaminated needles, vertical transmission (mother to child through infected birth canal), and sexual contact. [1] Neonates born of chronically infected mothers have a 70-90% risk of the infection progressing to a chronic phase. [3] Most countries in Africa have a high HBV endemicity, with the exception of Morocco and Tunisia, which have intermediate endemicity. [4] A prevalence rate of 10% of HBV was found among pregnant women in Hong Kong, [3] 12% in Taiwan, [5] and17.3% in Burkina Faso. [6] A b s t r A c t Background: Pregnant women infected with hepatitis B virus (HBV) can transmit the infection to their fetuses and newborns. Neonates who contract the HBV have about 90% risk of developing chronic HBsAg carriage (HBsAg: hepatitis B surface antigen) and chronic liver disease. Neonatal immunization interrupts this vertical and perinatal transmission. Objectives: To determine the seroprevalence of HBsAg among pregnant women attending the antenatal clinic at Aminu Kano Teaching Hospital (AKTH) and to identify potential risk factors associated with HBV infection. Materials and Methods: A case control study was conducted involving a total of 303 pregnant women attending the antenatal clinic at AKTH and 303 nonpregnant women of childbearing age. Blood sample was collected from each woman and the serum tested for the presence of HBsAg using latex rapid agglutination slide test kit (Cal-Tech Diagnostic Inc., USA) in the laboratory of the hospital. Reactive samples were stored at-20ºC and further confirmed for HBsAg using enzyme-linked immunosorbent assay (ELISA) kits (Bio-Rad, France). HBsAg-positive samples were tested for hepatitis B e antigen (HBeAg) using ELISA kits (Orgenics, Israel). A pretested, structured questionnaire was used for the collection of sociodemographic data and possible risk factors. Results: The prevalence of HBsAg among pregnant women and nonpregnant women were 7.9 and 7.6%, respectively. There was no statistically significant difference in the prevalence of HBsAg in pregnant and nonpregnant women. The presence of HBeAg was statistically significant among both pregnant and nonpregnant women who tested positive for HBsAg. The risk factors associated with HBV infection were blood transfusion, ear piercing, history of an affected sibling with HBV infection, tattooing, and abortion among pregnant women. Conclusion: The prevalence of HBsAg in this study was not statistically different in pregnant and nonpregnant women. There was a high level of HBeAg infection among pregnant women who tested positive for HBsAg. History of an affected sibling with HBV infection, tattoo, and abortion were significant risk factors for HBV infection.
Despite the existence of a safe and effective vaccine, Nigeria has remained a hyper-endemic area for hepatitis B virus infection, with estimated 12% of the total population being chronic carriers. Neonates who contact hepatitis B virus infection will have an almost 90% risk of developing chronic hepatitis B surface antigen (HBsAg) carrier state and chronic liver disease. The objectives of this study were to determine the sero-prevalence of hepatitis B surface antigen among pregnant women and identifying potential risk factors associated with the infection. This study involved a total of 350 pregnant women who attended antenatal at the Federal medical Centre, Umuahia, Abia State, Nigeria. Blood samples from all consenting pregnant women were collected. A structured pro forma designed for this purpose was used to obtain socio-demographic information and the presence of risk factors. Data collated was analyzed using GraphPad Prism statistical softwarewith P<0.05 at 95% confidence interval. The results showed that HBsAg sero-prevalence rate of 7.1% was observed in allthe pregnant women tested. Sero-prevalence of HBsAg amongst parturients were more in patients within their first trimesters (11.1%), Primigravida pregnant women (8.0%), women with history of dental or surgical procedures(34.0%) and multiple sexual partners (25.0%) and in women with no formal education (37.5%). An intermediate prevalence of HBsAg was identified which justifies the need for routine screening in pregnancy in order to identify and treat the infection, thus reducing the risk of transmission of the virus. Contraceptive options aimed at prevention of pregnancy and sexually transmitted infection (STI) should be encouraged.
British Journal of Medicine and Medical Research, 2015
Background: Vertical transmission of hepatitis B virus infection during pregnancy and delivery remains the major route of transmission in low resource areas. The objectives of this study were to determine the sero-prevalence of hepatitis B infection (HBsAg) and the potential risk factors among pregnant women admitted for delivery. Materials and Methods: This cross-sectional study of 300 women admitted for delivery was conducted at University of Calabar Teaching Hospital, Calabar, Nigeria. A pretested questionnaire was used for the collection of socio-demographic data and possible risk factors. Blood sample was collected from each consented woman and the plasma tested for the presence of HBsAg using rapid ELISA test Kits in the laboratory of the hospital. All the data were analyzed using microsoft BJMMR, 8(4): 324-333, 2015; Article no.BJMMR.2015.455 325 SPSS version 17 statistical program. Results: Out of the 300 women studied, positive HBsAg was detected in 14 women, giving a seroprevalence rate of 4.7%. The age of the women studied varied from 16 to 43 years with mean age of 27.9±4.6 years and mean parity of 1.1±1.5. Hepatitis B viral infection was significantly higher among pregnant women who did not attend any antenatal care (unbooked women) than pregnant women who attended antenatal care (booked women). There were statistically significant relationships between HBV infection and 2 or more sexual partners and previous history of induced abortion. Previous histories of blood transfusion, previous surgeries/dental manipulations, tribal marks/tattoos, previous contact with somebody with hepatitis B infection were not statistically significant. The data are related to 14 (4.7%) of HBV infected women in the study. Conclusion: An intermediate prevalence of hepatitis B virus infection was identified which justifies the need for routine screening in pregnancy especially among unbooked women in order to identify and treat the infection.
https://www.ijhsr.org/IJHSR\_Vol.9\_Issue.12\_Dec2019/IJHSR\_Abstract.01.html, 2019
Context and objective: The diagnosis of viral hepatitis during pregnancy raises the problem of its seriousness in women but also fetal risk and mother-to-child transmission. The objective of this study was to determine the HBsAg screening rate and risk factors associated with HBs Ag transmission among pregnant women in semi-urban and rural areas of the Democratic Republic of Congo. Methods: Cross-sectional study of 152 pregnant women conducted from June 29, 2017 to April 28, 2018, having consulted the Gynecology and Obstetrics service of two medical units, one in the semi-urban environment of the city of Kinshasa and the other in the middle rural, chosen in a random way. HBsAg was wanted by a rapid test. The analysis was done with SPSS 22. A multivariate logistic regression model was used to search for risk factors for HBV at the p <5% threshold. Results: The mean age was 26.3 ± 7.1 years. The frequency of HBsAg was 15.8%. The risk factors associated with HBsAg were non-condom use (aOR: 2.26), transfusion (aOR: 3.49), multiple sexual partner (aOR: 2.39) and number of Risque Factor > 4 (aOR: 2.44). Conclusion: The frequency of HBsAg in pregnant women in the DRC is high. The national system of management and risk prevention factors for hepatitis B in pregnant women need to be strengthened.
2015
This study was carried out to determine the prevalence of hepatitis B virus surface and core antigens among pregnant women visiting Ring Road Hospital for antenatal care in Ibadan, South-West, Local Government Area. Out of 150 blood samples collected and screened, using Diaspot® test strips, ten were found positive (6.6%). Pregnant women within 25-29 years had the highest prevalence of (2.7%) the lowest prevalence of 0.6% was found among pregnant women within the age group of 35-39 years. Pregnant women that are from polygamous family had (4.0%) while those from monogamous recorded 2.7%. Similarly, pregnant women with history of blood transfusion had 5.3% while those without history of blood transfusion recorded 1.3%. Chi-square analysis revealed that age, history of blood transfusion and family type are not related to infection with hepatitis B virus in the studied area. More awareness campaign should be organized in order to educate populacion on the possible route of transmission...
Clinical Microbiology and Research, 2019
Hepatitis B virus (HBV) when transmitted vertically can be severe on neonates and life threatening. Among others, risk factors for HBV include unprotected sex, needle-stick injuries and blood transfusion. The study was conducted to determine the seroprevalence of HBV markers and associated risk factors among one hundred and sixty consenting pregnant women attending some hospitals in Kano, Nigeria. Using enzymelinked immunoassay, sera were screened for HBV sero-markers and structured questionnaires were administered to obtain sociodemographic data and possible predisposing factors to HBV infection. Of the five HBV markers known, participants tested positive for four, which include HBsAg, HBsAb, HBeAb and HBcAb. All were seronegative for HBeAg. Ninety three percent (93.1%) tested positive for at least one HBV marker and 6.9% were seronegative for all markers. Among those that tested positive for HBsAg, 54.5% (p=0.33) were housewives, 36.4% (p=0.53) had only primary school education, 72.7% (p=0.14) were middle-class, none had previous knowledge of HBV infection and its mode of transmission, 54.5% (p=0.14) regularly shares sharp objects, 45.5% (p=0.37) had ear or nose piercing, and 9.1% (p=0.01) regularly shares towel and underwear. A large percentage of the study group had history of the infection while only 1.3% of the subjects were vaccinated. Sociodemographic background of the participants, low vaccination coverage and certain risk factors like the sharing of unsterilized sharp objects seem to aid the moderately high prevalence of HBV in this study. The study also revealed that the risk of mother-to-child HBV transmission is low in the study area and that incomplete vaccination may not confer artificial immunity against HBV infection.
Objectives: The objectives were to determine the seroprevalence of hepatitis B virus (HBV) infection and assess the major risk factors among Nigerian pregnant women. Subjects and Methods: This was a cross‑sectional descriptive study carried out among pregnant women at the antenatal clinic of a Tertiary Hospital in Lagos, Nigeria. A total number of 150 consenting pregnant women were selected for the study. A structured pretested interviewer‑administered questionnaire was used for the data collection. Sera were collected and tested for hepatitis B surface antigen (HBsAg) and hepatitis B e antigen (HBeAg). Results: Of the150 women screened during the study, 11 (7.3%) were seropositive for HBsAg. Of these 11 women, 4 (36.4%) were also positive for HBeAg. There was no statistically significant difference in the mean ages of participants who were seropositive for HBsAg and those who were negative for the virus (P = 0.888). There were statistically significant differences in the seroprevalence of HBsAg recorded among respondents with previous surgery (odd ratio [OR] ‑ 2.97; 95% confidence interval [CI] ‑ 1.08‑16.67; P = 0.046), previously affected sibling or spouse (OR ‑ 5.03; 95% CI ‑ 1.11–25.27; P = 0.001) and those with two or more lifetime sexual partners (OR ‑ 4.11; 95% CI ‑ 2.85–9.22; P = 0.024). Conclusion: The sero‑prevalence rate of HBV infection and also its infectivity is high in Lagos, Nigeria. These findings thus support the need for a nationwide policy of routine and widespread HBV screening among pregnant women.
International Journal of TROPICAL DISEASE & Health
Background: Hepatitis B control, especially among pregnant women and prospective blood donors, in the developing world is still a disease that must be given attention considering its mortality and morbidity rates. Methods: This study was conducted among 153 subjects including pregnant women and prospective blood donors using appropriate hepatitis B serological marker ELISA kits (WANTAI, China) for each marker. Results: Among the subjects screened, 38 had at least one of the markers. Among those that showed no detectable HBsAg were 2 prospective blood donors with HBeAg and another 6 prospective blood donors and 2 pregnant women with HBcAb-IgM detected in them all indicating an ongoing infection and replication of hepatitis B virus. Sexual activities were found to be of statistical significance in the study. Conclusion: It is imperative to give more attention to control of HBV spread through more sex education and administration of vaccination.
Pan African Medical Journal, 2019
Introduction: hepatitis B infection is caused by the hepatitis B virus (HBV). HBV is transmitted through sexual intercourse, by exchange of saliva during kissing and also to newborns of infected mothers. In the Global Burden of Diseases 2010, 786,000 deaths were attributed to HBV. Studies in Cameroon, reported the prevalence of HBV as high as 10.1% and 12% among blood donors in hospital blood banks. This study ther efore, aims at determining the prevalence of HBsAg, knowledge and practices of pregnant women on HBV prevention and transmission in the Limbe Health District (LHD) and Muyuka Health District (MHD). Methods: ANC registers were exploited from the health centers for a period of three years (2014-2016) in order to determine the prevalence of HBV infection. 270 women attending ANC were selected by exhaustive sampling. Knowledge and practices of participants on HBV prevention and transmission was assessed using a structured questionnaire. Results: the prevalence of HBV in the LHD and MHD were 5.7% and 7.5% respectively. Pregnant women in the LHD demonstrated good knowledge but adopted poor practices whereas in the MHD, pregnant women demonstrated poor knowledge and adopted poor practices regarding the mode of transmission and prev ention of HBV infection. There was a significant association between the prevalence of HBsAg and marital status (p = 0.000) in the LHD and age (p = 0.022) in the MHD. Conclusion: this study indicated a high prevalence of HBV among pregnant women in the LHD and MHD, knowledge and practices were identified as potential risk factors.
Pan African Medical Journal, 2015
Introduction: Hepatitis B virus is responsible for 50%-80% of Hepatocellular carcinoma cases worldwide. In Nigeria, vertical transmission remains a major route of Hepatitis B virus infection. Primary (vaccines and post-exposure prophylaxis) and secondary prevention of HBV transmission by appropriate sexual and sanitary practices are not yet optimal in the country yet measures for early detection (serological, molecular) and treatment of infected pregnant women is not a practice. This study aimed at identifying the prevalence and risk factors for Hepatitis B virus infection among pregnant women in Ibadan, Southwestern Nigeria. Methods: A cross-sectional study was done at the Antenatal clinic of the University College Hospital Ibadan. One hundred and eighty pregnant women were recruited from March to August 2013, and tested for Hepatitis B surface antigen (BIORAD FRANCE) using third generation ELISA, as well as HIV-1 and 2 using Uni-Gold Recombigen and ALERE determine (a rapid immunoassay designed to detect antibodies to HIV 1 and/or 2). Positive HBsAg samples were tested for Hepatitis B envelope antigen, antibody and Hepatitis B core antibody (DIAPRO Italy) while serum HBV DNA was detected using PCR. Data were obtained using questionnaires to establish and analysis was performed using SPSS version 20. Results: The seroprevalence of HBsAg was 8.3% out of which 26.7% were positive for HBeAg, 53.3% had HBeAb, 20% had neither HBeAg nor HBeAb, 100% had total HBcAb and 86.7% had HBV DNA in their serum. The mean age was 32.1years, the highest HBV infection rate occurred in 25-29 year age group. Multiple sexual partners (OR-3.987, P-value=0.026) and early age at sexual debut (OR 11.996, P-value=0.022) were independent risk factors for HBV infection. Conclusion: Hepatitis B virus infection is of high endemicity in Nigeria thus early detection, treatment of infected pregnant women, immunoprophylaxis for exposed newborns and surveillance for those with chronic infection is essential. Health education programs on prevention and control measures must be instituted.