Photodynamic therapy - alternative treatment method of oral mucosa inflammatory diseases (original) (raw)
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Photodynamic Therapy in the Treatment of Periodontal Disease
2020
Biofilms that colonize tooth surfaces and epithelial cells lining the periodontal pocket ⁄ gingival sulcus (subgingival dental plaques) are among the most complex biofilms that exist in nature. Photodynamic therapy has been suggested as an alternative to chemical antimicrobial agents to eliminate subgingival species and treat periodontitis. Antimicrobial photodynamic therapy seems to be a unique and interesting therapeutic approach towards the treatment of periodontitis and peri-implantitis. The results of a number of in vitro studies clearly demonstrate the effective and efficient bactericidal effect of antimicrobial photodynamic therapy. Antimicrobial photodynamic therapy may hold promise as a substitute for currently available chemotherapy in the treatment of periodontal and peri-implant diseases.
Vojnosanitetski pregled
Porphyromonas gingivalis i Treponema denticola nalazili su se u statistički značajno manjem broju nakon primenjene terapije(p<0,001). Kauzalna terapija u kombinaciji s aPTD je dovela do statistički značajnog pobljšanja kako kliničkih parametatra, tako i mikrobiološkog statusa u odnosu na kauzalnu terapiju samostalno. Zaključak. Istraživanje je pokazalo da je došlo do poboljšanja svih kliničkih pokazatelja nakon primene oba modaliteta terapije. Ukupni broj mikroorganizama je smanjen kao i broj specifičnih mikroorganizama. Kombinacija antimikrobne fotodinamske terapije s kauzalnom terapijom pokazala je smanjenje broja mikroorgnizama u odnosu na kauzalnu terapiju samostalno. Ključne reči: Parodontopatija, Kauzalna terapija parodontopatije, Antimiktobna fotodinamska terapija.
Proceedings of the International Conference on Biomedical Electronics and Devices, 2012
Photodynamic therapy (PDT) is recently being recognized as an attractive, non-invasive and alternative treatment method for precancerous lesions and superficial cancers. PDT has many advantages when compared with conventional treatment modalities. It has also been used for the photoinactivation of microbes. There is an increasing interest in the practical application of antimicrobial photodynamic therapy (aPDT) in many branches of dentistry, especially in periodontology, for the management of such conditions as chronic periodontitis or periimplantitis. The aim of the present paper was to discuss the application of photodynamic therapy in medicine and dentistry. The results of many so far published studies seem to be very promising indicating at the same time that further research is needed to establish the optimal protocol for effective photodestruction of tumor cells and microorganisms.
Photodynamic Therapy in Periodontics
2020
The human oral cavity is colonized by a large number of highly diverse bacteria existing in either a planktonic community or in a complex sessile community known as a biofilm (i.e. dental plaque).1While the majority of bacteria in these complex communities are nonpathogenic some bacteria are opportunistic pathogens and are associated with extraoral and intraoral diseases. Photodynamic therapy has been considered as a promising novel therapeutic approach for eradicating pathogenic bacteria in periodontal and peri-implant diseases. Photodynamic therapy is based on chemicals called photosensitizers that are activated by light of adequate wavelength. Its activation leads to the generation of singlet oxygen and free radicals responsible for the cytotoxic effect against specific cells. Photodynamic therapy basically involves three nontoxic ingredients: visible harmless light; a nontoxic photosensitizer; and oxygen. It is based on the principle that a photosensitizer (i.e. a photoactivatab...
Photodynamic Therapy-A New Ray of Hope in Periodontics
2017
Microbial biofilm in the oral cavity is the primary etiology for periodontal disease. It has been found that the growth of bacteria in dental plaque biofilm imparts to them an increased resistance to antimicrobial agents as compared to bacteria grown in suspensions and adherent cultures. Hence there is pronounced interest and keenness for the development of alternate therapeutic modalities, one such approach is the photodynamic therapy (PDT). This review provides an overview of PDT in the management of periodontal disease. Also new frontiers of antimicrobial PDT research have been discussed. Thus, the available knowledge of PDT should encourage a more clinically oriented application of this technique.
Photodynamic Therapy- A Ray towards Periodontics
IOSR Journal of Dental and Medical Sciences, 2014
The increase of microbial resistance and development of lighting devices with safe and accurate delivery of energy, today professionals can count on therapies to manage pathogens in different fields of dentistry, especially periodontics. The possibility of development of resistance to antibiotics by the target organism has led to development of a new concept with fewer complications i.e. Photodynamic Therapy. The combination of laser light and photosensitizer known as photodynamic therapy (PDT) can be used in periodontal therapy. LASER produces a monochromatic, collimated and coherent light beam. This unique form of light can interact with living tissues leading to surgical and/ or therapeutic applications. A Photosensitizer is a dye substance that is absorbed by the microorganism, cell or tissue allowing it to interact with the light. This mode of treatment is referred to as photodynamic therapy (PDT) or photo-activated disinfection (PAD). Application of photodynamic therapy in periodontics such as pocket debridement, gingivitis, aggressive periodontitis continue to evolve into a mature clinical treatment modality, and is considered as a promising novel approach for eradicating pathogenic bacteria in periodontitis. This Article presents an overview of photodynamic therapy as it represents a novel therapeutic approach in the management of periodontal diseases.
Frontiers in chemistry, 2024
Objective: This study investigated the effect of photodynamic therapy on chronic periodontitis patients and then evaluated the microbial, immunological, periodontal, and clinical outcomes. The significant effects of photodynamic therapy obtained by in vitro and in vivo studies have made it a popular treatment for periodontal diseases in recent years. Photodynamic therapy is a novel bactericidal strategy that is stronger, faster, and less expensive than scaling and root planing. Method: This study registered on PROSPERO (CRD42021267008) and retrieved fifty-three randomized controlled trials by searching nine databases (Medline, Embase, Scopus, Open Gray, Google Scholar, ProQuest, the Cochrane Library, Web of Science, and ClinicalTrials.gov) from 2008 to 2023. Of 721 records identified through database searches following title and full-text analysis, and excluding duplicate and irrelevant publications, 53 articles were included in this systematic review. Fifty of the 53 eligible studies fulfilled all the criteria in the Joanna Briggs Institute's (JBI's) Checklist for RCTs; the remaining articles met 9-12 criteria and were considered high quality. Results: The present study showed that photodynamic therapy in adjunct to scaling and root planing has the potential to improve periodontal parameters such as clinical attachment loss or gain, decrease in bleeding on probing, and probing pocket depth. In addition, photodynamic therapy decreases the rate of periodontal pathogens and inflammation markers, which, in turn, reduces the progression of periodontitis. Conclusion: Photodynamic therapy is considered a promising, adjunctive, and low-cost therapeutic method that is effective in tissue repair, reducing chronic periodontitis, reducing inflammation, and well-tolerated by patients.
Photodynamic Therapy: Role in Dentistry (A Brief Review)
SVOA Dentistry, 2020
Bacteria form a biofilm that is the safest habitat for them. Pathogenic bacteria are the main etiological factor responsible for the failure of various treatments. Quorum sensing helps bacteria to communicate with each other and coordinates with their activity. Mechanical debridement with antimicrobial therapy is usually a conventional mode of periodontitis patients. Another effective tool is Photodynamic therapy for localized and superficial infections. This article summarizes the history, general principles, applications, indications, mechanism, and adverse effects of photodynamic therapy in various fields of dentistry.
Photodynamic therapy: the imminent milieu for treating oral lesions
Journal of clinical and diagnostic research : JCDR, 2013
Photodynamic therapy (PDT) is used in curative and palliative treatment of head and neck squamous cell carcinoma (HNSCC) and other oral lesions. Oral infections (such as mucosal and endodontic infections, periodontal diseases, caries, and peri-implantitis) are among the specific targets where PDT can be applied Photodynamic therapy (PDT) efficacy depends on the local dose deposited in the lesion as well as oxygen availability in the lesion. Further long-term clinical studies are necessary in establishing a more specific place of the technique in the field of dentistry.